We strengthen known results on Diophantine approximation with restricted denominators by presenting a new quantitative Schmidt-type theorem that applies to denominators growing much more slowly than in previous works. In particular, we can handle sequences of denominators with polynomial growth and Rajchmann measures exhibiting arbitrary slow decay, allowing several applications. For instance, our results yield non-trivial lower bounds on the Hausdorff dimensions of intersections of two sets of inhomogeneously well-approximable numbers (each with restricted denominators) and enable the construction of Salem subsets of well-approximable numbers of arbitrary Hausdorff dimension.