Charis Psaltis (this volume) states that the direct predecessors of the theoretical framework of genetic psychology he is developing in his comprehensive chapter can be found in Piaget’s Genetic Epistemology, Lucien Goldmann’s Genetic Structuralism, and Serge Moscovici’s Genetic Model of Social Influence. The ideas of these scholars were further elaborated in Gerard Duveen’s contributions directed towards the advancement of genetic social psychology. Charis Psaltis states that common threads binding these approaches together were the concepts of the dialectics of genesis and structure, part-whole relations, and temporality. Psaltis emphasises that these common threads were linked with the fundamental epistemological questions that had already preoccupied philosophers such as Immanuel Kant, Georg W. F. Hegel, and Karl Marx. In this commentary I shall suggest that while the questions about the nature of knowledge bind these philosophers together, their proposed answers surpass their common links because, depending on their epistemological presuppositions, their answers are based on diverse concepts concerning the nature of knowledge. Consequently, these answers were reflected in different ways in the contributions of Piaget, Goldmann, Moscovici and Duveen in their studies of the dialectics of genesis and structure.