International Relations scholarship has shown that persisting epistemic hierarchies rooted in colonial domination continue to exclude, silence, or sideline alternative knowledges in global governance, even as International Organizations increasingly open up to formally marginalized groups and attempt to pluralize their expertise. While building on such accounts, this article argues that epistemic hierarchies are deeply entangled with political-economic logics, which permeate global epistemic politics in multiple ways. These intersecting epistemic and political-economic logics produce complex forms of ‘political-epistemic disciplining’, which do not simply exclude alternative knowledges, but rearticulate them. I identify three intertwined modalities of this process: de-epistemization, whereby alternative knowledge claims are recoded as social or identity concerns rather than treated as competing epistemologies. This operation recognizes the subjects of the critique but not the epistemic critique itself. Conditional recognition occurs when prevailing criteria of validity regulate the acknowledgement of such claims. Finally, transposition constitutes or reformulates alternative knowledge claims through the lenses of dominant epistemic frameworks and categories. These processes rearticulate alternative knowledges and transform them a new into ‘globalized alternative knowledges’. The argument is developed through an in-depth analysis of engagements with Indigenous knowledges in Global Mental Health governance.

Dr. C. Norman Coleman, a distinguished cancer specialist and researcher, brought a passion for addressing health disparities to all of his roles from being on the faculty as a Radiation Oncologist at Stanford, as Chair of the Joint Center for Radiation Oncology at Harvard, as Associate Director of the Radiation Research Program at the U.S. National Cancer Institute, as Senior Medical Advisor to the US Government Office of the Assistant Secretary for Preparedness and Response, and as co-founder and Senior Scientific Officer for the International Cancer Expert Corps. With his passing earlier this year, this commentary by his colleagues at the International Cancer Expert Corps presents an overview of his many and significant contributions to addressing cancer disparities globally.

Dr. C. Norman Coleman’s impact is difficult to measure overall, even if one focuses only on his work as NCI’s Radiation Research Program (RRP) leader. His laboratory work spanned immune-oncology and radiation therapy, RNA biology, normal tissue and tumor tissue radiobiology, and the development of tissue chips for use in radiation biology research. His programmatic leadership helped the RRP develop health equity programs addressing Native American access to optimal cancer care, evaluation of hadron therapy biology, radiation biology, reproducibility and rigor, foundational molecular biology of the tumor and normal tissue caused by radiation therapy dynamically, and global health and security issues. While doing all these things, he found time to mentor countless people in the field, many now leaders, and to read and discuss science across disciplines. He was a dedicated, caring, kind scientist who truly wanted to help and improve the world for others.

Digitalisation in health introduces new actors, risks, and challenges into health governance. Global health institutions such as World Bank, World Health Organisation, and the now-disbanded US Agency for International Development play a central role in shaping how governments navigate this evolving technical terrain. This paper examines digital health discourses of these organisations in the early 2020s, asking why, how, and by whom digital health is promoted. Using Political Discourse Analysis, we study three flagship documents, selected from 72. Our analysis shows that these organisations engage in depoliticisation, portraying digital health as an inevitable wave that governments must adopt rapidly and extensively. This techno-optimist framing overlooks government capacity gaps concerning the complexity of strategic adoption and asymmetric power relations with technology providers, and the absence of political engagement with risks and challenges. These discourses foster a depoliticised vision of digital health, overlooking the political mechanisms for digitalisation to benefit the public.

Hyderabad, the fourth-most populous city in India, accounts for the majority of people living with human immunodeficiency virus (HIV) (PLWH) in Telangana, likely comprised of two populations with a disproportionately high national HIV prevalence: gay, bisexual, and other men who have sex with men (MSM) and those who engage in sex work (SW). Research has shown that engaging in SW increases vulnerability to HIV transmission risk for both women and MSM, but less is known about contributors to non-optimal (ART) adherence. We analyzed data from 45 MSM and 49 women living with HIV who were enrolled in the first year of data collection from an mHealth education study in Hyderabad. Modified Poisson regression was used to measure factors associated with ART adherence measured with a visual analogue scale (VAS) (model 1) and pill count (model 2). Less than half (40.9%) reported ever engaging in SW, including 13 women and 25 MSM. The prevalence of non-optimal ART adherence was 14.9% with VAS and 42.4% with pill count. Engaging in SW was not associated with non-optimal ART adherence. Differences in non-optimal ART adherence measured by VAS and pill count suggest that future studies should utilize both methods to better distinguish the measures.

This paper examines the goals of organizations that sponsor short-term volunteer trips in global health, whether they be NGO’s, faith-based, educational, or corporate organizations. Results from a U.S.-based national survey of 177 such organizations and 27 interviews with trip organizers suggest that organizations often sponsor volunteer trips to achieve goals that are quite different from the improvement of health outcomes in poor countries. While providing health services is often cited as the most important goal, volunteer activity is also considered important in enhancing the organizations’ reputation, recruitment and retention, and financial well-being. The prominence of other goals has the potential for diverting resources and focus from what is presumably the primary purpose of serving host communities in the most effective manner possible.

The increasing health inequity and injustice of the COVID-19 pandemic rendered visible the inadequacy of global health governance, and exposed the self-interested decision-making of states and pharmaceutical companies. This research explores the advocacy activities of humanitarian and development international non-governmental organizations (INGOs) in responding to this inequality and investigates how they framed alternatives for global health justice. It reviews 47 organizational documents and 43 media articles of five INGOs (ActionAid, Médecins Sans Frontières, Oxfam, Save the Children, and World Vision) and points to the importance of understanding advocacy frames in analyzing how these organizations prioritize agendas and advocacy strategies. The dominance of the ‘human rights’ frame, sometimes in combination with ‘scientific evidence’ and ‘security’ frames, reflects the identities, mandates, and histories of campaigning and collaboration of these INGOs. This paper contends that the advocacy of humanitarian and development INGOs highlights both deontological and teleological ethics, promoting the voices of people in lower-income countries, clarifying duty bearers and their accountabilities, and addressing structural barriers from a human rights perspective in a global health agenda setting.

Public communication about antimicrobial resistance (AMR) is widely acknowledged as a cornerstone of global, national, and regional strategies to tackle this urgent health threat. However, much like AMR itself, efforts to communicate about it are hindered by complex and intersecting challenges. This scoping review synthesises insights from 88 scholarly manuscripts published between 2015 and 2024 to explore critical issues in AMR communication and identify potential options to address them. We distil nine overarching themes that underpin effective public communication and engagement, with particular significance for engaging with disadvantaged and vulnerable communities. These themes encompass (1) social science theoretical frameworks, (2) varied sociocultural contexts, (3) public engagement and dialogue, (4) linguistic considerations, (5) messaging strategies, (6) media use and its impacts, (7) large-scale public campaigns, (8) creative communication approaches, and (9) evaluation. We discuss each theme and outline related recommendations, collectively advocating a re-imagining of AMR communication as a civic, cultural, and reflexive practice that is attuned to the complexities of diverse contexts and cultures, and designed to enhance societal relevance and impact.

Clinicians in paediatric cardiology have unique exposure to different pathologies and treatment based on geographic location and resource availability. “Cardiology Across Continents” is a virtual, case-based discussion series aimed at knowledge sharing across a variety of practice and resource settings. We report on a recent case discussion highlighting a rare cause of new-onset heart failure in a teenager, which is more frequently seen among African and Asian populations.

Two expert groups on global health from Norway and Denmark have recently made important strides in reenergizing the debate on the role of the Nordic countries in global health. Their tailored recommendations — emphasizing core values of human rights, equity, accountability, and local ownership alongside health security — have proven influential at a time when new forms of international collaboration in global health are urgently needed.

We investigated the potential yield of conducting active case finding for tuberculosis (TB) within a defined geographic radius (50 or 100 m) around the households of individuals diagnosed with TB at health facilities. In a well-defined geographic area within Kampala, Uganda, residential locations were determined for 85 people diagnosed with TB at local health facilities over an 18-month period and for 60 individuals diagnosed with TB during a subsequent community-wide door-to-door screening campaign. Ten of the individuals diagnosed through community screening lived within 50 m of an individual previously diagnosed with TB in a local health facility (TB prevalence: 0.98%), and 15 lived at a distance of 50–100 m (prevalence: 0.87%). The prevalence ratio was 1.4 (95% confidence interval (CI): 0.7–2.9) for those <50 m and 1.2 (95% CI 0.6–2.2) for those 50–100 m, compared to >100 m. Using TB notifications to identify areas for geographically targeted case finding is at most moderately more efficient than screening the general population in the context of urban Uganda.

Bloodstream infections (BSIs) caused by Candida are a significant cause of morbidity and mortality. Geographical variations exist in the epidemiology of candidemia, with a paucity of data in the many low- and middle-income countries. We performed a retrospective study of candidemia from 2017 to 2022 at a 289-bed teaching hospital in the Dominican Republic (DR). A total of 197 cases were reviewed. Overall mortality rate was 49.2%. Age and vasopressor use were associated with mortality. The most prevalent Candida species were C. tropicalis and C. parapsilosis. C. albicans was 12% resistance to amphotericin B. These findings underscore the importance of understanding local epidemiology and may help inform empiric therapy and the development of treatment guidelines in the DR.