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The premorbid phase of treatment-resistant schizophrenia (TRS) may reveal underlying mechanisms and inform early interventions. According to the neurodevelopmental hypothesis, treatment resistance may be linked to pronounced developmental impairments. We examined school grades and attendance trajectories in children who later developed TRS.
Methods
This case-control study analyzed school grade point average and attendance among all individuals born after 1990 and started on clozapine in Chile’s public health system as a proxy for TRS. Control groups included children later diagnosed with treatment-responsive schizophrenia, bipolar disorder, and unaffected classmates. Linear mixed models accounted for individual and school-level confounders.
Results
We included 1072 children (9929 observations, 29.3% female) subsequently diagnosed with TRS, 323 (2802 observations, 25.7% female) with schizophrenia, 175 (1784 observations, 53.8% female) bipolar disorder, and 273,260 (533,335 observations, 47% female) unaffected classmates. Children who later developed TRS had worse grades across levels than their classmates (−0.26 SD [−0.2, −0.4]), but not treatment-responsive schizophrenia. All severe mental illness groups showed grade declines in later school levels, with TRS showing steeper linear decline than treatment-responsive schizophrenia (group×age of −0.03; 95%CI −0.04, −0.01) and steeper quadratic decline than bipolar disorder (group×age2 of −0.005; −0.01, −0.001). Attendance declined over time in the two groups developing schizophrenia compared to their classmates. Those developing TRS experienced the sharpest drop (group×age compared to schizophrenia −0.03; −0.05, −0.01 and bipolar disorder −0.027; −0.049, −0.006).
Conclusions
TRS may stem from a more aggressive pathological process or pronounced late-maturation abnormality, rather than an early premorbid impairment, suggesting an intervention target.
The content learned in paediatric cardiology fellowship is variable depending on the socio-economic and geographic setting in which training takes place and may result in knowledge gaps. We highlight the key lessons learned from a recent case-based learning session, hosted by Heart University, between two programmes from different geographic and resource settings.
Crowded Out delves into the complex landscape of international non-governmental organizations (INGOs). Bush and Hadden trace INGOs' rise to prominence at the end of the twentieth century and three significant but overlooked recent trends: a decrease in new INGO foundings, despite persistent global need; a shift toward specialization, despite the complexity of global problems; and a dispersal of INGO activities globally, despite potential gains from concentrating on areas of acute need. Assembling a wealth of new data on INGO foundings, missions, and locations, Bush and Hadden show how INGOs are being crowded out of dense organizational environments. They conduct case studies of INGOs across issue areas, relying on dozens of interviews and a large-scale survey to bring practitioners' voices to the study of INGOs. To effectively address today's global challenges, organizations must innovate in a crowded world. This title is also available as open access on Cambridge Core.
Under the umbrella of solidarity missions, since the early 1960s, Cuba’s socialist government has dispatched tens of thousands of medical brigades to geographically diverse locales. This approach to humanitarian medical aid, according to the Cuban government, is an act of solidarity grounded in an ethos of social justice. The magnitude of this brand of humanitarianism far outpaces the most iconic faces of the contemporary global health industry. Despite these important if not groundbreaking roles in primary healthcare, for most readers in North America and Europe, Cuba likely occupies the rhetorical and discursive space of the singular “case study” or “alternative,” if it even makes an appearance. How do we understand the absence–presence of Cuba’s medical-internationalism efforts as a non-event in the global health landscape? This chapter explores the structuring logics shaping global health’s dominant script – the problematics, concepts, methods, and practices – that render different imaginaries of care and aid illegible, thus unthinkable.
Kawasaki disease is a systemic vasculitis that primarily affects young children and represents a major cause of acquired heart disease in children in developed countries. The incidence of Kawasaki disease exhibits significant global variation, and the worldwide burden remains limited.
Methods:
A systematic review was conducted to investigate the global incidence of Kawasaki disease in children under 5 years of age. A comprehensive literature search was performed in PubMed, Embase, and KoreaMed up to July 15, 2024. Studies reporting population-level Kawasaki disease incidence were included. Data extraction and quality assessment were performed independently by two reviewers.
Results:
The search yielded 3,197 articles, of which 105 met the inclusion criteria. These studies examined Kawasaki disease incidence in children under 5 years of age across 34 countries, with the majority focusing on the Western Pacific Region and the Region of the Americas. The results demonstrated a wide range of Kawasaki disease incidence globally, with significant geographic variations. The highest incidence rates were observed in Japan, Korea, and Taiwan, with a trend of gradual increase over time.
Conclusions:
This study represents the most comprehensive review of global Kawasaki disease incidence to date. The substantial variation in incidence underscores the need to understand the factors influencing regional differences.
In a world of growing health inequity and ecological injustice, how do we revitalize medicine and public health to tackle new problems? This groundbreaking collection draws together case studies of social medicine in the Global South, radically shifting our understanding of social science in healthcare. Looking beyond a narrative originating in nineteenth-century Europe, a team of expert contributors explores a far broader set of roots and branches, with nodes in Sub-Saharan Africa, South America, Oceania, the Middle East, and Asia. This plural approach reframes and decolonizes the study of social medicine, highlighting connections to social justice and health equity, social science and state formation, bottom-up community initiatives, grassroots movements, and an array of revolutionary sensibilities. As a truly global history, this book offers a more usable past to imagine a new politics of social medicine for medical professionals and healthcare workers worldwide. This title is also available as open access on Cambridge Core.
Sleep is essential for the health of midlife women, yet the barriers (factors that impede) and facilitators (factors that support) to achieving adequate sleep, particularly among working-class women in Mexico City and broader Latin American contexts, remains insufficiently understood. This study aims to provide a nuanced understanding of the factors influencing sleep among working-class midlife women in Mexico City. A mixed-methods approach, combining quantitative data (epidemiologic measures) and qualitative data (ethnographic interviews), was employed among women enrolled in a Mexico City cohort. We used epidemiologic data to describe sleep and its correlates in a sample of 120 women, incorporating both self-reported (questionnaires and sleep diaries) and behavioral (actigraphy-based) measures of sleep. A subset of 30 women participated in in-depth ethnographic interviews to explore determinants of sleep, including barriers, facilitators and coping strategies to compensate for sleep loss. Our findings reveal that many women experienced poor sleep, with 43% reporting insomnia-related difficulties and 53% experiencing short sleep duration. Barriers included family-related stress, particularly caregiving responsibilities, economic instability, and mental health challenges. In response to sleep loss, women often resorted to coping mechanisms, such as caffeine consumption and napping, and the use of natural remedies. This study highlights the critical role social factors, including family dynamics and caregiving roles, in shaping sleep health outcomes. Sleep, as an inherently social behavior, is strongly influenced by these contextual factors. These findings underscore the importance of considering psychosocial and cultural contexts in interventions aimed at promoting healthy sleep in midlife women.
To generate and employ scenarios of sentinel human and animal outbreak cases in local contexts that integrate human and animal health interests and practices and facilitate outbreak risk management readiness.
Methods
We conducted a scoping review of past outbreaks and the strengths and weaknesses of response efforts in USAID STOP Spillover program countries. This information and iterative query-and-response with country teams and local stakeholders led to curated outbreak scenarios emphasizing One Health human:animal interfaces at sub-national levels.
Results
Two core scenarios were generated adapted to each of 4 countries’ pathogen priorities and workflows in Africa and Asia, anchoring on sub-national outbreak response triggered by either an animal or human health event. Country teams subsequently used these scenarios in a variety of local preparedness discussions and simulations. The process of creating outbreak scenarios encourages discussion and review of current country practices and procedures. Guideline documents and lessons learned do not necessarily reflect how workflows occur in outbreak response in countries at highest risk for spillover events.
Conclusions
Discussion-based engagement across One Health stakeholders can improve sub-national coordination, clarify guidelines and responsibilities, and provide a space for interagency cooperation through use of scenarios in tabletop and other exercises.
During outbreaks of diseases like cholera, HIV/AIDS, H1N1, and Ebola, governments often impose international border restrictions (for example, quarantines, entry restrictions, and import restrictions) that disrupt the economy without stopping the spread of disease. During COVID-19, international travel restrictions were ubiquitous despite initial World Health Organization recommendations against such measures because of their limited public health benefit and the potential for imposing a range of harms. Why did governments adopt these measures? This article argues and finds evidence that governments use international border restrictions as security theatre: ‘measures that provide not security, but a sense of it’. Quantitative analysis of original data on states’ first border restrictions during the pandemic suggests that behaviour was not just driven by the risk of COVID-19 spread. Instead, nationalist governments, which are likely to be attracted to policies associating disease with foreigners, were more likely to impose border restrictions, did so more quickly, and adopted domestic measures more slowly. A case study of the US further illustrates the security theatre logic. The findings imply that overcoming or redirecting governments’ attraction to security theatre could promote international cooperation during global health emergencies.
In the decade since the first edition of Global Health Law was published, the world has moved incrementally towards global health with justice, at least by one basic metric: life expectancy has edged up globally, with more rapid gains in low- than high-income countries. But to look around the world, global health with justice still seems a distant dream. Health gaps between people in rich and poor countries remain shocking and unconscionable—as do health inequities within countries. The pandemic also gave salience to profound health injustices—from injustices in access to lifesaving vaccines to gaping disparities in morbidity and mortality based on income, race, and national origin. So did the Trump administration’s decision to pause, and then slash, foreign assistance, bringing an end to lifesaving programs around the world. Guided by the overarching theme of justice, these reflections canvass the history of global health law as a field and discuss developments and challenges in the field across four core themes: multilateralism; equitable distribution of the benefits of scientific advancement; global health law for the poly-crises; and human rights and equity.
The article examines the historical development of global health from its genesis in colonial-era tropical medicine, to the creation of the World Health Organization – formed to advance health rights for all. The authors call for continued reforms to the global health governance system to mitigate the enduring impact of colonialism.
Colonialism has produced the global health system, and decoloniality must inform global health law. This article considers the foundational impact of colonialism on the global health system and advocates for adopting decoloniality as a crucial framework to reshape global health law. Through a historical lens, it examines how European colonialism established power dynamics and structures that continue to influence contemporary global health governance. This article calls for overcoming enduring challenges by emphasizing the urgency of dismantling outdated and unjust systems that perpetuate health inequities and hinder effective interventions. It argues for a paradigm shift toward epistemically inclusive, ethical, and equitable practices, emphasizing the active participation of marginalized communities in health policymaking. By addressing the root causes of health disparities and decoupling health systems from racial capitalism, a decolonial approach promises a more just and effective future for global health law.
Global health law in theory and practice can either work to ameliorate the devastating consequences of colonialism, class hierarchies, and structural racism in health, or it can ratify and exacerbate them. It can protect, under protect, overprotect, or fail to protect – it is not and cannot be neutral. Global health law reflects the choices and practices of States and other actors, which includes both action and inaction. Inaction or silence on the part of global health law is a choice that ratifies the status quo of coloniality, class exploitation, and structural racism in health.
This article first describes shifts in human rights law that have led to improvements in the realization of sexual and reproductive health and rights (SRHR) over the last decade. The article does so, however, with careful attention to the structural factors beyond formal legal mechanisms that may undermine the ability of governments, even with the best of intentions, to fully develop the necessary robust health and justice systems. Second, this article considers two additional factors: the political economy factors that enable or limit the ability of States to realize SRHR, as well as the growing evidence base that supports positive legal transformation.
It has been ten years since the publication of Professor Larry Gostin’s pathbreaking contribution to law, medicine, and public health, Global Health Law (Harvard University Press, 2014). As Professor Sofia Gruskin’s review in The Lancet noted, the book “brings attention to critical aspects of law that anyone interested in global health needs to be concerned about…” This sentiment was echoed throughout the academy, civil society, among non-governmental organizations, legislative bodies, and even courts.
Professor Gostin’s legacy fits among those who harnessed their wisdom, expertise, and voices for the betterment of others and who recognized that chief among the worst harms for any people to endure is the denial of healthcare. This year, one decade after the publication of this of Global Health Law and numerous articles, commentaries, and books, it is clear that Professor Lawrence O. Gostin refuses to be silent on matters that concern the health of the most vulnerable in our world. Our planet is better for his very presence and commitment to what is just, kind, and compassionate.
In longer-form writing with Larry Gostin, especially on global health, I have been particularly struck by how careful he is not to lose the narrative voice, especially of the vulnerable. He truly believes that these stories are “on loan” to us, and that there is an almost holy reverence and devotion we owe to the lives of those whose stories we tell.
A tribute to Professor Larry Gostin for a special issue of the Journal of Law, Medicine, and Ethics to mark the 10th anniversary of the launch of "Global Health Law".
Communities and individuals globally continue to suffer the violent impacts of colonialism and racism, in a global system of governance that remains rooted in unequal and hierarchical power imbalances. The interpersonal, societal, and structural violence that persists around the world exists in violation of human rights, and is evidence of a persistent lack of political will to effectively invest in human rights, including the right to health, as a true priority.
The demand on States and non-State actors to fulfil the human right to health is imperative. Attacks on civilians during times of conflict and catastrophe, as seen in the latest escalation and display of imperial aggression by Israel in the occupied Palestinian territory, demonstrate the consistent uneven application of human rights and commitment to fulfilling them.
Protecting human rights, and specifically the realization of the right to health, is fundamental as it has significant consequences for the realisation of other human rights. Eliminating discrimination requires paying sufficient attention to groups of individuals that suffer historical or persistent prejudice. Fulfilling a commitment to health equity and justice demands creating opportunity and conducive conditions for the dignity for all people.