This article argues for a metapoetic reading of the Talos episode in Apollonius of Rhodes, in which Medea symbolically annihilates Theocritus’ Polyphemus, the bucolic hero who had found a pharmakon to cure lovesickness. The distinctive phrases λεπτὸς ὑμήν ‘a thin membrane’ and σύριγξ αἱματόεσσα ‘a blood-filled vein’ are metapoetic signals: ‘a refined Callimachean marriage song’ and ‘bloody pan-pipes’, evoking Theocritus. The Cyclops’s peaceful response to romantic disappointment is well attested in other Hellenistic poems with medical overtones. The Talos episode engages these with other medical and Homeric allusions to contrast Medea’s outward destructive use of the Muses’ sciences with Polyphemus’ inward healing use.