Mental health legislation across Africa has evolved significantly from colonial-era frameworks. An adapted version of the FOSTREN* (Fostering and Strengthening Approaches to Reducing Coercion in European Mental Health Services) instrument, which is a comprehensive assessment tool based on the World Health Organisation Mental Health Legislation Checklist and the United Nations Convention on the Rights of Persons with Disabilities, was used to analyse mental health laws from Nigeria, Egypt, Ghana, Cabo Verde and Kenya. The comparative analysis showed varying alignment with international human rights standards, reflecting complex interactions between global frameworks and local realities. All the mental health laws analysed show movement towards rights-based approaches, although implementation challenges related to resource constraints, service delivery capacity and cultural integration remain significant barriers. Ghana’s formal integration of complementary and alternative medicine into its mental health framework, which requires cooperation between the Mental Health Authority and Traditional and Alternative Medicine Council, and the inclusion of people with lived experience of mental health conditions in review panels are examples of innovative approaches that show promise for regional adoption. While some form of supported decision-making is available, none of the countries offer advanced care directives. The study highlights that legislative reform alone is insufficient without addressing contextual factors like poverty, healthcare financing and integration of traditional healing practices in developing rights-based mental health care systems.