This paper addresses the challenges and preparedness strategies for health care systems in responding to nuclear and radiological emergencies. It emphasizes the critical role of medical centers in pre-incident preparedness, immediate response, and long-term care, focusing on the need for coordinated efforts between local, state, and federal agencies. Key components include specialized training, resource allocation, triage protocols, and the integration of networks like the Radiation Injury Treatment Network and the American Burn Association. This paper highlights the importance of resilience through collaboration, infrastructure planning, and community support to manage mass casualties and mitigate long-term health consequences. It underscores the lessons learned from historical responses and contemporary challenges, advocating for a proactive approach to enhance health care system readiness in the face of catastrophic events.