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Chapter 13 - Crystallization in the Pharmaceutical Industry

Published online by Cambridge University Press:  14 June 2019

By
Simon N. Black
Edited by
Allan S. Myerson ,
Deniz Erdemir  and
Alfred Y. Lee
Allan S. Myerson
Affiliation:
Massachusetts Institute of Technology
Deniz Erdemir
Affiliation:
Bristol-Myers Squibb, USA
Alfred Y. Lee
Affiliation:
Merck & Co., Inc
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Summary

Most crystallizations in the pharmaceutical industry are not carried out by crystallization scientists. The Cambridge Structure Database (CSD) contains over 850,000 crystal structures, and the number of organic molecules that have been isolated as solids is much larger. In many cases these isolations have not been repeated or scaled up. Yet this task, namely the development of robust, reproducible crystallization processes, is the main topic of this chapter. By way of introduction, meet the types of molecules, the types of people, and the nature of the industry.

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Handbook of Industrial Crystallization , pp. 380 - 413
Publisher: Cambridge University Press
Print publication year: 2019

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