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Psychotoxic Effects of Benzhexol Hydrochloride (Artane)

Published online by Cambridge University Press:  29 January 2018

D. A. Stephens
D. A. Stephens*
Affiliation:
St. Luke's Hospital, Middlesbrough, Yorks
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Extract

Benzhexol hydrochloride (Artane, Pipanol, Trihexyphenidyl) was the first of a range of synthetic antispasmodic drugs to be made available for the symptomatic treatment of Parkinsonism. Selected as the most potent of a series of substituted piperidyl propanols examined pharmacologically by Cunningham et al. (1949), it was shown to have half the activity of atropine sulphate in inhibiting neurogenic spasm in isolated rabbit intestine. This activity was associated with advantageously reduced mydriatic, anti-sialogogic and vagal inhibitory properties in laboratory animals.

Information

Type
Research Article
Information
The British Journal of Psychiatry , Volume 113 , Issue 495 , February 1967 , pp. 213 - 218
Copyright
Copyright © Royal College of Psychiatrists, 1967 

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