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Detection of antibodies against Fasciola hepatica in cirrhotic patients from Peru

Published online by Cambridge University Press:  01 March 2009

L.A. Marcos ,
A. Bussalleu ,
A. Terashima  and
J.R. Espinoza
L.A. Marcos*
Affiliation:
Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH), Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru Department of Internal Medicine, University of Texas Health Science, Houston, TX, USA
A. Bussalleu
Affiliation:
Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH), Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru
A. Terashima
Affiliation:
Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH), Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru
J.R. Espinoza
Affiliation:
Laboratorios de Investigación y Desarrollo (LID), Facultad de Ciencias y Filosofía ‘Alberto Cazorla Talleri’, Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru
*
*E-mail: Luis.A.Marcos@uth.tmc.edu
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Abstract

The prevalence of Fasciola hepatica infection, in endemic countries, in patients with established cirrhosis is unknown. We hypothesized that, in endemic countries, the presence of fascioliasis may be detected in a serum pool of cirrhotic patients. Forty-four previously stored serum samples of patients with established liver cirrhosis, in the Hospital Nacional Cayetano Heredia in Lima, Peru, were collected from 1998 to 2003 and assessed for hepatitis B, C and fascioliasis antibodies (Fas2 ELISA). Hepatitis B surface antigen (HBsAg) was positive in 8.8% (n = 34), hepatitis B core antibody (anti-HBc) in 32.5% (n = 34), hepatitis C antibodies (anti-HCV) in 9.1% (n = 33), and 9.1% (n = 44) were Fas2 ELISA positive. This disease is an example of an emerging tropical infection which can be present in chronic liver diseases, requiring greater clinician awareness especially in endemic rural areas. Further clinical studies are warranted.

Information

Type
Research Note
Information
Journal of Helminthology , Volume 83 , Issue 1 , March 2009 , pp. 23 - 26
Copyright
Copyright © Cambridge University Press 2009

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References

Almendras-Jaramillo, M., Rivera-Medina, J., Seijas-Mogrovejo, J. & Almendras-Jaramillo, K. (1997) Hepatic fascioliasis in children: uncommon clinical manifestations. Arquivos de gastroenterologia 34, 241–247.Google ScholarPubMed
Arjona, R., Riancho, J.A., Aguado, J.M., Salesa, R. & Gonzalez-Macias, J. (1995) Fascioliasis in developed countries: a review of classic and aberrant forms of the disease. Medicine (Baltimore) 74, 13–23.CrossRefGoogle ScholarPubMed
Barham, W.B., Figueroa, R., Phillips, I.A. & Hyams, K.C. (1994) Chronic liver disease in Peru: role of viral hepatitis. Journal of Medical Virology 42, 129–132.CrossRefGoogle ScholarPubMed
Campbell, A.J., Sheers, M., Moore, R.J., Edwards, S.R. & Montague, P.E. (1981) Proline biosynthesis by Fasciola hepatica at different developmental stages in vivo and vitro. Molecular Biochemistry of Parasitology 3, 91–101.CrossRefGoogle ScholarPubMed
Córdova, M., Herrera, P., Ñopo, L., Bellatin, J., Náquira, C., Guerra, H. & Espinoza, J.R. (1997) Fasciola hepatica cysteine proteinases: immunodominant antigens in human fascioliasis. American Journal of Tropical Medicine and Hygiene 57, 660–666.CrossRefGoogle ScholarPubMed
Córdova, M., Reategui, L. & Espinoza, J. (1999) Immunodiagnosis of human fasciolasis with Fasciola hepatica cysteine proteinases. Transactions of the Royal Society of Tropical Medicine and Hygiene 93, 54–57.CrossRefGoogle Scholar
Espinoza, J.R., Timoteo, O. & Herrera-Velit, P. (2005) Fas2-ELISA in the detection of human infection by Fasciola hepatica. Journal of Helminthology 79, 235–240.CrossRefGoogle ScholarPubMed
Espinoza, J.R., Maco, V., Marcos, L.A., Saez, S., Neyra, V., Terashima, A., Samalvides, F., Gotuzzo, E., Chavarry, E., Huaman, M.C., Bargues, M.D., Valero, M.A. & Mas-Coma, S. (2007) Evaluation of Fas2-ELISA for the serological detection of Fasciola hepatica infection in humans. American Journal of Tropical Medicine and Hygiene 76, 977–982.CrossRefGoogle ScholarPubMed
Haridy, F.M., Ibrahim, B.B., Morsy, T.A. & El-Sharkawy, I.M. (1999) Fascioliasis an increasing zoonotic disease in Egypt. Journal of Egypt Society of Parasitology 29, 35–48.Google ScholarPubMed
Heredia, D., Bordas, J.M., Mondelo, F. & Rodes, J. (1984) Gallbladder fascioliasis in a patient with liver cirrhosis. Medicina Clínica (Barcelona) 82, 768–770.Google Scholar
Keiser, J. & Utzinger, J. (2005) Emerging foodborne trematodiasis. Emerging Infectious Diseases 11, 1507–1514.CrossRefGoogle ScholarPubMed
MacLean, L. (1999) Liver, lung, and intestinal fluke infections. pp. 1039–1057in Guerrant, G.L., Walker, D.H. & Weller, P.F. (Eds) Tropical infectious diseases: principles, pathogens and practice. Orlando, FL, Harcourt Brace.Google Scholar
Marcos, L.A. & Terashima, A. (2007) Update on human fascioliasis in Peru: diagnosis, treatment and clinical classification proposal. Neotropical Helminthology 1, 85–103.CrossRefGoogle Scholar
Marcos, L.A., Maco, V., Terashima, M.A., Samalvides, F. & Gotuzzo, E. (2004) Características clínicas de la infección crónica por Fasciola hepatica en niños. Revista de Gastroenterologia Perú 22, 228–233.Google Scholar
Marcos, L.A., Maco, V., Florencio, L., Terashima, A., Samalvides, F., Miranda, E., Tantaleán, M., Espinoza, J.R. & Gotuzzo, E. (2005a) Altas tasas de prevalencia de fasciolosis humana en el Peru: una enfermedad emergente. Revista Peruana de Enfermedades Infecciosas y Tropicales 3, 8–13.Google Scholar
Marcos, L.A., Maco, V., Castillo, M., Terashima, A., Zerpa, R. & Gotuzzo, E. (2005b) Reporte de casos de fasciolosis en el Instituto Especializado de Salud del Niño (1988–2003). Revista de Gastroenterologia del Perú 25, 198–205.Google Scholar
Marcos, L.A., Terashima, A., Leguia, G., Canales, M., Espinoza, J.R. & Gotuzzo, E. (2007a) Fasciola hepatica infection in Peru: an emergent disease. Revista Gastroenterologia del Peru 27, 389–396.Google ScholarPubMed
Marcos, L.A., Yi, P., Machicado, A., Andrade, R., Samalvides, F., Sanchez, J. & Terashima, A. (2007b) Hepatic fibrosis and Fasciola hepatica infection in cattle. Journal of Helminthology 81, 381–386.CrossRefGoogle ScholarPubMed
Marcos, L.A., Terashima, A. & Gotuzzo, E. (2008a) Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis. Current Opinion Infectious Disease 21, 523–530.CrossRefGoogle ScholarPubMed
Marcos, L.A., Tagle, M., Terashima, A., Bussalleu, A., Ramirez, C., Carrasco, C., Valdez, L., Huerta-Mercado, J., Freedman, D.O. & Gotuzzo, E. (2008b) Natural history, clinico-radiologic correlates and response to triclabendazole in acute massive fascioliasis. American Journal of Tropical Medicine and Hygiene 78, 222–227.CrossRefGoogle Scholar
Mark, L.G. & Isseroff, H. (1983) Levels of type I and type III collagen in the bile duct of rats infected with Fasciola hepatica. Molecular Biochemistry of Parasitology 8, 253–262.CrossRefGoogle ScholarPubMed
Mas-Coma, S. (2005) Epidemiology of fascioliasis in human endemic areas. Journal of Helminthology 79, 207–216.CrossRefGoogle ScholarPubMed
Modavi, S. & Isseroff, H. (1984) Fasciola hepatica: collagen deposition and other histopathology in the rat host's bile duct caused by the parasite and by proline infusion. Experimental Parasitology 58, 239–244.CrossRefGoogle ScholarPubMed
Perez, J., Martin de las Mulas, J., Carrasco, L., Gutierrez, P.N., Martinez-Cruz, M.S. & Martinez-Moreno, A. (1999) Pathological and immunohistochemical study of the liver and hepatic lymph nodes in goats infected with one or more doses of Fasciola hepatica. Journal of Comprehensive Pathology 120, 199–210.CrossRefGoogle ScholarPubMed
Phiri, A.M., Phiri, I.K., Sikasunge, C.S., Chembensofu, M. & Monrad, J. (2006) Comparative fluke burden and pathology in condemned and non-condemned cattle livers from selected abattoirs in Zambia. Onderstepoort Journal of Veterinary Research 73, 275–281.Google ScholarPubMed
Sanchez-Sosa, S., Rojas-Ortega, S., Reed-San Roman, G. & Torres-Santana, M.A. (2000) Massive hepatobiliary fascioliasis. Revista de Gastroenterologia de Mexico 65, 179–183.Google ScholarPubMed
Shirai, W., Sato, T., Shibuya, H., Naito, K. & Tsukise, A. (2006) Anatomicopathological study of vascular and biliary systems using cast samples of fasciola-infected bovine livers. Journal of Veterinary Medicine Series A Physiology Pathology Clinical Medicine 53, 239–245.CrossRefGoogle ScholarPubMed
Wolf-Spengler, M.L. & Isseroff, H. (1983) Fascioliasis: bile duct collagen induced by proline from the worm. Journal of Parasitology 69, 290–294.CrossRefGoogle ScholarPubMed