Hostname: page-component-76fb5796d-22dnz Total loading time: 0 Render date: 2024-04-26T14:47:05.124Z Has data issue: false hasContentIssue false
  • English
  • Français

Squamous cell carcinoma of the oropharynx: single-institution outcome analysis of patients treated with concurrent chemoradiotherapy

Published online by Cambridge University Press:  23 February 2015

R Yasumatsu ,
T Nakashima  and
S Komune
R Yasumatsu*
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
T Nakashima
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
S Komune
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
*
Address for correspondence: R Yasumatsu, Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3–1–1 Maidashi, Higashi-ku, Fukuoka 812–8582, Japan Fax: + 81 92 6425685 E-mail: yasuryuj@qent.med.kyushu-u.ac.jp
Get access Rights & Permissions [Opens in a new window]

Abstract

Purpose:

The object of this study was to analyse our experience with the effects of concurrent chemoradiotherapy for oropharyngeal squamous cell carcinoma, the treatment results of this therapeutic strategy and a salvage treatment for recurrent oropharyngeal squamous cell carcinoma.

Methods:

Seventy-five patients with oropharyngeal squamous cell carcinoma were treated with chemoradiotherapy. The study included twenty-five of these patients who had recurrent oropharyngeal squamous cell carcinoma after chemoradiotherapy

Results:

The three-year actuarial survival rates for 75 patients by disease stage were as follows: stage II, 100 per cent; stage III, 71.1 per cent; stage IV, 51.7 per cent and overall, 58.2 per cent. The mean time of detection of recurrence was 6.2 months. The total salvage rates of recurrence were 21 per cent. The one and three-year tumour-free actuarial survival rates of those patients who received salvage treatment were 83 and 33 per cent.

Conclusions:

Surgical salvage was only feasible for early recurrent tumour. Close follow-up surveillance of early recurrence is essential after primary treatment of patients with chemoradiotherapy.

Keywords

Oropharyngeal CancerChemoradiotherapySalvage Treatment
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue S2 , March 2015 , pp. S77 - S82
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Jesse, RH, Sugarbaker, EV. Squamous cell carcinoma of the oropharynx: why we fail. Am J Surg 1976;132:435–8CrossRefGoogle ScholarPubMed
2Righini, CA, Nadour, K, Faure, C, Rtail, R, Morel, N, Beneyton, V et al. Salvage surgery after radiotherapy for oropharyngeal cancer. Treatment complications and oncological results. Eur Ann Otorhinolaryngol Head Neck Dis 2012;129:11–16Google Scholar
3Nichols, AC, Kneuertz, PJ, Deschler, DG, Lin, DT, Emerick, KS, Clark, JR et al. Surgical salvage of the oropharynx after failure of organ-sparing therapy. Head Neck 2011;33:516–24CrossRefGoogle ScholarPubMed
4Goodwin, WJ Jr. Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means? Laryngoscope 2000;110:1–18Google Scholar
5Calais, G, Alfonsi, M, Bardet, E, Sire, C, Germain, T, Bergerot, P et al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst 1999;91:2081–6CrossRefGoogle ScholarPubMed
6Cohan, DM, Popat, S, Kaplan, SE, Rigual, N, Loree, T, Hicks, WL Jr. Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg 2009;17:88–94CrossRefGoogle ScholarPubMed
7Chen, AY, Schrag, N, Hao, Y, Stewart, A, Ward, E. Changes in treatment of advanced oropharyngeal cancer, 1985–2001. Laryngoscope 2007;117:16–21CrossRefGoogle ScholarPubMed
8Cmelak, AJ, Li, S, Goldwasser, MA, Murphy, B, Cannon, M, Pinto, H et al. Phase II trial of chemoradiation for organ preservation in resectable stage III or IV squamous cell carcinomas of the larynx or oropharynx: results of Eastern Cooperative Oncology Group Study E2399. J Clin Oncol 2007;25:3971–7Google Scholar
9Huang, K, Xia, P, Chuang, C, Weinberg, V, Glastonbury, CM, Eisele, DW et al. Intensity-modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma: the University of California-San Francisco experience. Cancer 2008;113:497–507CrossRefGoogle ScholarPubMed
10Zafereo, ME, Hanasono, MM, Rosenthal, DI, Sturgis, EM, Lewin, JS, Roberts, DB et al. The role of salvage surgery in patients with recurrent squamous cell carcinoma of the oropharynx. Cancer 2009;115:5723–33CrossRefGoogle ScholarPubMed
11Bachar, GY, Goh, C, Goldstein, DP, O'Sullivan, B, Irish, JC. Long-term outcome analysis after surgical salvage for recurrent tonsil carcinoma following radical radiotherapy. Eur Arch Otorhinolaryngol 2010;267:295–301Google Scholar
12Agra, IM, Carvalho, AL, Ulbrich, FS, de Campos, OD, Martins, EP, Magrin, J et al. Prognostic factors in salvage surgery for recurrent oral and oropharyngeal cancer. Head Neck 2006;28:107–13Google Scholar