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Efficacy of diced cartilage with or without platelet-rich fibrin in an animal nasal septal perforation model

Published online by Cambridge University Press:  27 February 2026

Halis Çölkesen Open the ORCID record for Halis Çölkesen [Opens in a new window] ,
Çağdaş Elsürer ,
Serdar Uğraş ,
Vedat Uslu ,
Muslu Kazım Körez  and
Bülent Ulusoy Open the ORCID record for Bülent Ulusoy [Opens in a new window]
Halis Çölkesen*
Affiliation:
Department of Otorhinolaryngology–Head and Neck Surgery, Faculty of Medicine, Selçuk University, Konya, Turkey
Çağdaş Elsürer
Affiliation:
Department of Otorhinolaryngology–Head and Neck Surgery, Faculty of Medicine, Selçuk University, Konya, Turkey
Serdar Uğraş
Affiliation:
Department of Pathology, Faculty of Medicine, Selçuk University, Konya, Turkey
Vedat Uslu
Affiliation:
Department of Otorhinolaryngology–Head and Neck Surgery, Faculty of Medicine, Selçuk University, Konya, Turkey
Muslu Kazım Körez
Affiliation:
Department of Biostatistics, Faculty of Medicine, Selçuk University, Konya, Turkey
Bülent Ulusoy
Affiliation:
Department of Otorhinolaryngology–Head and Neck Surgery, Faculty of Medicine, Selçuk University, Konya, Turkey
*
Corresponding author: Halis Çölkesen; Email: hlsclksn@hotmail.com
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Abstract

Objective

This study aimed to evaluate the efficacy of diced cartilage and platelet-rich fibrin–wrapped diced cartilage in nasal septal perforation repair.

Methods

Thirty-six rabbits were allocated to three groups. The Control group underwent repair with flaps; the Diced Cartilage group received cartilage grafts with flaps; and the Diced Cartilage plus Platelet-Rich Fibrin group received platelet-rich fibrin–coated diced cartilage with flaps.

Results

Persistent perforations occurred in all controls. Closure rates were 66.7 per cent in the Diced Cartilage group and 81.8 per cent in the Diced Cartilage plus Platelet-Rich Fibrin group, both significantly higher than controls (p < 0.001), with no significant difference between graft groups. Fibrosis level and re-epithelialisation scores were significantly increased in both graft groups versus controls (p < 0.001).

Conclusion

Inter-positional graft use is crucial for successful nasal septal perforation repair; diced cartilage is an effective alternative when block cartilage is unavailable, and platelet-rich fibrin combination may further enhance outcomes.

Keywords

animal experimentationcartilagenasal septal perforationplatelet-rich fibrin

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 140 , Issue 5 , May 2026 , pp. 528 - 534
Copyright
© The Author(s), 2026. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

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Footnotes

Halis Çölkesen takes responsibility for the integrity of the content of the paper

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