Hostname: page-component-76d6cb85b7-f97m6 Total loading time: 0 Render date: 2026-07-27T18:54:33.631Z Has data issue: false hasContentIssue false
  • English
  • Français

Accuracy of register- and record-based bipolar I disorder diagnoses in Finland; a study of twins

Published online by Cambridge University Press:  18 September 2015

T. Kieseppä ,
T. Partonen ,
J. Kaprio  and
J. Lönnqvist
T. Kieseppä*
Affiliation:
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
T. Partonen
Affiliation:
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
J. Kaprio
Affiliation:
Department of Public Health, University of Oulu, Oulu, Finland
J. Lönnqvist
Affiliation:
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
*
National Public Health Institute, Department of Mental Health and Alcohol Research, Mannerheimintie 166, 00300 Helsinki 30, FinlandTel 358-9-4744 8857, Fax 358-9-4744 8478, E-mail tuula.kieseppa@ktl.fi
Get access Rights & Permissions [Opens in a new window]

Abstract

Registers have been widely used in schizophrenia studies. For bipolar disorder, the use has been more limited and no studies exist concerning accuracy of bipolar I diagnoses in registers. We have collected an unselected twin sample for a study of bipolar I disorder. We report here the diagnostic procedures and accuracy of bipolar I diagnoses in a nation-wide hospital discharge registry. We evaluated also the accuracy of the medical record-based best-estimate diagnoses, comparing these with the SCID interview diagnoses. From the National Hospital Discharge Register we identified all like-sex twins, born 1940-1957, (N=42), and all like- or opposite-sex twins, born 1961-1969, (N=15), who had at least once a diagnosis of bipolar I disorder. The best-estimate diagnoses based on medical records, and were made by two doctors blind to each other, and according to DSM-IV-criteria. Diag-noses were then confirmed by SCID interviews, with the mi-nimum follow-up time after the first admission being 6 years. The accuracy of bipolar diagnoses in the register was 92% and 87%, accordingly. When comparing the best-estimate diagnoses to SCID interview diagnoses, there was one false positive case in the first sample, 3.4% [95% CI 0.1% to 7.8%], and none in the second sample. Our study shows that a diagnosis of bipolar I disorder in the hospital discharge register, or if based only on medical records, is highly reliable and stable. These results strengthen the usefulness of regis-ters also in bipolar disorder.

Keywords

bipolar disordermanic type of schizoaffective disorderregistrydiagnosticstwin study

Information

Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 3 , September 2000 , pp. 106 - 109
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1.Cluss, PA. Marcus, SC. Kelleher, KJ. Thasc, ME. Arvay, LA. Kupfer, DJ. Diagnostic certaintv of a voluntary bipolar disorder case registry. J Affect Disord 1999:52:93–99.CrossRefGoogle ScholarPubMed
2.Kendler, KS. Pedersen, NL. Farahmand, BY. Persson, PG. The treated incidence of psychotic and affective illness in twins compared with population expectation: a studv in the Swedish Twin and Psychiatric Registries. Psychol Med 1996:26:1135–1144.CrossRefGoogle Scholar
3.Hovatta, I. Terwillinger, JD. Lichterman, D. Mäkikyrö, T. Suvisaari, J. Peltonen, L. Lönnqvist, J. Schizophrenia in the genetic isolate of Finland. Am J Med Genet (Neuropsychialic Genetics) 1997:74:353–360.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
4.Cannon, TD. Kaprio, J. Lönnqvist, J. Huttunen, M. Koskenvuo, M. The genetic epidemiology of schizophrenia in a Finnish twin cohort: a population based modeling study. Arch Gen Psychiatry 1998:55:67–74.CrossRefGoogle Scholar
5.Suvisaari, JM. Haukka, J. Tanskanen, A. Lönnqvist, JK. Age at onset and outcome in schizophrenia are related to the degree of familial loading. Br J Psychiatry 1998:173:494–500.CrossRefGoogle Scholar
6.Mäkikyrö, T. Isohanni, M. Moring, J. Hakko, H. Hovatta, I. Lönnqvist, J. Accuracy of register-based schizophrenia diagnoses in a genetic study. Lump Psychiatry 1998:13:57–62.Google Scholar
7.Bertelsen, A. Harvald, B. Hauge, M. A Danish twin study of manic-depressive disorders. Br J Psychiatry 1977:130:330–351CrossRefGoogle ScholarPubMed
8.Kendler, KS. Pedersen, N. Johnson, L. Neale, MC. Mathe, AA. A pilot Swedish twin-study of affective illness, including hospital- and population- ascertained subsamples. Arch Gen Psychiatry 1993:50:699–706.CrossRefGoogle ScholarPubMed
9.World Health Organization. Manual of the International Statistical Classification of Diseases. Injuries and Causes of Death (8th edn) (ICD-8). Geneva. WHO. 1967.Google Scholar
10.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (3th edn) (DSM-III-R). Washington. DC. American Psychiatric Press. 1987.Google Scholar
11.Kaprio, J. Sarna, S. Koskenvuo, M, Rantasalo, I. The Finnish Twin Registry: Formation and compilation, queslionnare study, zygosity determination procedures and research program. Progr Clin Biol Res 1978:24B: 179–184.Google Scholar
12.Kaprio, J. Lessons from twin studies in Finland [editorial]. Ann Med 1994:26:135–139.CrossRefGoogle ScholarPubMed
13.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSMTV). Washington. DC. American Psychiatric Press. 1994.Google Scholar
14.Kendler, KS, Karkowski, LM. Walsh, D. The structure of psychosis. Latent class analysis of probands from the Roscommon family study. Arch Gen Psychiatry 1998:55:492–499.CrossRefGoogle ScholarPubMed
15.Spitzer, RL. Gibbon, M. Williams, JBW. The Structured Clinical Interview for DSM-IV Axis I and II Disorders (SCID I-II). Washington. DC. American Psychiatric Press. 1997.Google Scholar