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HIV-1-Associated Neuropathies

Published online by Cambridge University Press:  07 November 2014

Ashok Verma  and
Walter G. Bradley
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Abstract

Peripheral neuropathy associated with human immunodeficiency virus type 1 (HIV-1) infection is a major cause of morbidity in this patient population. Due to the associated chronic pain, its management has come within the purview of neuropsychiatrists. This paper will focus on the primary pathogenic aspects of HIV-1–associated peripheral neuropathies. The specific syndromes of greatest concern are distal sensory polyneuropathy, toxic neuropathy, inflammatory demyelinating polyradiculoneuropathy, and cytomegalovirus-related progressive polyradiculoneuropathy. The treatments available for these conditions and their efficacy are discussed.

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Type
Feature Articles
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CNS Spectrums , Volume 5 , Issue 5: HIV and the Central Nervous System: Part Two , May 2000 , pp. 66 - 72
Copyright
Copyright © Cambridge University Press 2000

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References

REFERENCES

1.Centers for Disease Control and Prevention. Pneumocystis pneumonia—Los Angeles. MMWR. 1981;30:250–252.Google Scholar
2.World Health Organization. The Current Global Situation of the HIV/AIDS Pandemic. Geneva, Switzeriand: WHO Global Program on AIDS; 1994:1.Google Scholar
3.AIDS and HIV-1 infection worldwide. Commun Dis Rep CDR Wkly. 1995;5:97–98.Google Scholar
4.Levy, RM, Bredesen, DE. Central nervous system dysfunction in acquired immunodeficiency syndrome. J Acquir Immune Defic Syndr. 1988;1:41–64.Google ScholarPubMed
5.Lipkin, WI, Parry, G, Kiprov, D, et al.Inflammatory neuropathy in homosexual men with lymphadenopathy. Neurology. 1985;35:1479–1483.CrossRefGoogle ScholarPubMed
6.Eidelberg, D, Sotrel, A, Vogel, H, et al.Progressive polyradiculopathy in acquired immune deficiency syndrome. Neurology. 1986;36:912–916.CrossRefGoogle ScholarPubMed
7.Bailey, RO, Baltch, AL, Venkatesh, R, et al.Sensory motor neuropathy associated with AIDS. Neurology. 1988;38:886–891.CrossRefGoogle ScholarPubMed
8.Price, RW, Brew, BJ. Central and peripheral nervous system complications. In: Curran, J, Essex, M, Fauci, AS, eds. AIDS. New York, NY: Lippincott-Raven; 1997:331–344.Google ScholarPubMed
9.de la Monte, SM, Gabuzda, DH, Ho, DD, et al.Peripheral neuropathy in the acquired immunodeficiency syndrome. Ann Neurol. 1988;23:485–492.CrossRefGoogle ScholarPubMed
10.Fiala, M, Cone, LA, Cohen, N, et al.Responses of neurologic complications of AIDS to 3'-azido-3'-deoxythymidine and 9-(l,3-dihydroxy-2-propoxymethyl) guanine, I: clinical features. Rev Infect Dis. 1988;10:250–256.CrossRefGoogle Scholar
11.Janssen, RS, Saykin, AJ, Kaplan, JE, et al.Neurological complications of human immunodeficiency virus infection in patients with lymphadenopathy syndrome. Ann Neurol. 1988;23:49–55.CrossRefGoogle ScholarPubMed
12.Lange, DJ, Britton, CB, Younger, DS, et al.The neuromuscular manifestations of human immunodeficiency virus infections. Arch Neurol. 1988;45:1084–1088.CrossRefGoogle ScholarPubMed
13.Leger, JM, Bouche, P, Bolgert, F, et al.The spectrum of polyneuropathies in patients infected with HIV. J Neurol Neurosurg Psychiatry. 1989;52:1369–1374.CrossRefGoogle ScholarPubMed
14.Mah, V, Vartavarian, LM, Akers, MA, et al.Abnormalities of peripheral nerve in patients with human immunodeficiency virus infection. Ann Neurol. 1988;24:713–717.CrossRefGoogle ScholarPubMed
15.Barohn, RJ, Gronseth, GS, LeForce, BR, et al.Peripheral nervous system involvement in a large cohort of human immunodeficiency virus-infected individuals [published correction appears in Arch Neurol. 1993;50:388]. Arch Neurol. 1993;50:167–171.CrossRefGoogle Scholar
16.Berger, AR, Arezzo, JC, Schaumburg, HH, et al.2',3′-dideoxycytidine (ddC) toxic neuropathy: a study of 52 patients. Neurology. 1993;43:358–362.CrossRefGoogle ScholarPubMed
17.Kieburtz, KD, Seidlin, M, Lambert, JS, et al.Extended follow-up of peripheral neuropathy in patients with AIDS and AIDS-related complex treated with dideoxyinosine. J Acquir Immune Defic Syndr. 1992;5:60–64.Google ScholarPubMed
18.Browne, MJ, Mayer, KH, Chafee, SB, et al.2',3'-didehydro-3'-deoxythymidine (d4T) in patients with AIDS or AIDS-related complex: a phase I trial. J Infect Dis. 1993;167:21–29.CrossRefGoogle ScholarPubMed
19.So, YT, Holtzman, DM, Abrams, DI, et al.Peripheral neuropathy associated with acquired immunodeficiency syndrome: prevalence and clinical features from a population-based survey. Arch Neurol. 1988;45:945–948.CrossRefGoogle ScholarPubMed
20.Cornblath, DR, McArthur, JC. Predominantly sensory neuropathy in patients with AIDS and AIDS-related complex. Neurology. 1988;38:794–796.CrossRefGoogle ScholarPubMed
21.Cornblath, DR. Treatment of the neuromuscular complications of human immunodeficiency virus infection. Ann Neurol. 1988;23(suppl):88–91.CrossRefGoogle ScholarPubMed
22.Chavanet, P, Giroud, M, Lancon, JP, et al.Infraclinical neuropathies in HIV+ patients [letter]. Presse Med. 1987;16:1764.Google Scholar
23.Berger, AR, Schaumburg, HH, Gourevitch, MN, et al.Prevalence of peripheral neuropathy in injection drug users. Neurology. 1999;53:592–597.CrossRefGoogle ScholarPubMed
24.Farizo, KM, Buehler, JW, Chamberland, ME, et al.Spectrum of disease in persons with human immunodeficiency virus infection in the United States. JAMA. 1992;267:1798–1805.CrossRefGoogle ScholarPubMed
25.Nakagawa, M, Maruyama, Y, Sugita, H, et al.Nationwide survey of neurologic manifestations of acquired immunodeficiency syndrome in Japan [comment]. Intern Med. 1997;36:175–178.CrossRefGoogle ScholarPubMed
26.Marra, CM, Boutin, P, Collier, AC. Screening for distal sensory peripheral neuropathy in HIV-infected persons in research and clinical settings. Neurology. 1998;51:1678–1681.CrossRefGoogle ScholarPubMed
27.Gastaut, JL, Gastaut, JA, Pellissier, JF, et al.Peripheral neuropathies in human immunodeficiency virus infection: a prospective study of 56 patients [in French]. Rev Neurol (Paris). 1989;145:451–459.Google ScholarPubMed
28.Cruz, MW, Correa, RB, Puccioni-Sohler, M, et al.Electroneuromyography and somatosensory evoked potentials in HTLV-I associated myelopathy [in Portuguese]. Arq Neuropsiquiatr. 1998;56:756–762.CrossRefGoogle ScholarPubMed
29.Fuller, GN, Jacobs, JM, Guiloff, RJ. Association of painful peripheral neuropathy in AIDS with cytomegalovirus infection. Lancet. 1989;2:937–941.CrossRefGoogle ScholarPubMed
30.Thornton, CA, Latif, AS, Emmanuel, JC. Guillain-Barre syndrome associated with human immunodeficiency virus infection in Zimbabwe. Neurology. 1991;41:812–815.CrossRefGoogle ScholarPubMed
31.Moyle, GJ, Sadler, M. Peripheral neuropathy with nucleoside antiretrovirals: risk factors, incidence and management. Drug Saf. 1998;19:481–494.CrossRefGoogle ScholarPubMed
32.Miller, RG, Peterson, GW, Daube, JR, et al.Prognostic value of electrodiagnosis in Guillain-Barré syndrome. Muscle Nerve. 1988;11:769–774.CrossRefGoogle ScholarPubMed
33.Behar, R, Wiley, C, McCutchan, JA. Cytomegalovirus polyradiculoneuropathy in acquired immune deficiency syndrome. Neurology. 1987;37:557–561.CrossRefGoogle ScholarPubMed
34.Miller, RG, Storey, JR, Greco, CM. Ganciclovir in the treatment of progressive AIDS-related polyradiculopathy. Neurology. 1990;40:569–574.CrossRefGoogle ScholarPubMed
35.Said, G, Lacroix, C, Chemouilli, P, et al.Cytomegalovirus neuropathy in acquired immunodeficiency syndrome: a clinical and pathological study. Ann Neurol. 1991;29:139–146.CrossRefGoogle ScholarPubMed
36.Said, G, Lacroix-Ciaudo, C, Fujimura, H, et al.The peripheral neuropathy of necrotizing arteritis: a clinicopathological study. Ann Neurol. 1988;23:461–465.CrossRefGoogle ScholarPubMed
37.Bradley, WG, Verma, A. Painful vasculitic neuropathy in HIV-1 infection: relief of pain with prednisone therapy. Neurology. 1996;47:1446–1451.CrossRefGoogle ScholarPubMed
38.Petratos, S, Turnbull, VJ, Papadopoulos, R, Ayers, M, Gonzales, MF. Antibodies against peripheral myelin glycolipids in people with HIV infection. Immunol Cell Biol. 1998;76:535–541.CrossRefGoogle ScholarPubMed
39.Petratos, S, Turnbull, VJ, Papadopoulos, R, et al.High titre anti-sulphatide antibodies in HIV-infected individuals. Neuroreport. 1999;10:2557–2562.CrossRefGoogle ScholarPubMed
40.Vendrell, J, Heredia, C, Pujol, M, et al.Guillain-Barré syndrome associated with seroconversion for anti-HTLV- III [letter]. Neurology. 1987;37:544.CrossRefGoogle ScholarPubMed
41.Stricker, RB, Abrams, DI, Corash, L, Shuman, MA. Target platelet antigen in homosexual men with immune thrombocytopenia. N Engl J Med. 1985;313:1375–1380.CrossRefGoogle ScholarPubMed
42.Winchester, R, Bernstein, DH, Fischer, HD, Enlow, R, Soloman, G. The co-occurrence of Reiter's syndrome and acquired immunodeficiency. Ann Intern Med. 1987;106:19–26.CrossRefGoogle ScholarPubMed
43.Berger, JR, Sheremata, WA, Resnick, L, et al.Multiple sclerosis-like illness occurring with human immunodeficiency virus infection. Neurology. 1989;39:324–329.CrossRefGoogle ScholarPubMed
44.Griffin, DE, McArthur, JC, Cornblath, DR. Neopterin and interferon-gamma in serum and cerebrospinal fluid of patients with HIV-associated neurologic disease. Neurology. 1991;41:69–74.CrossRefGoogle ScholarPubMed
45.Rance, NE, McArthur, JC, Cornblath, DR, et al.Gracile tract degeneration in patients with sensory neuropathy and AIDS. Neurology. 1988;38:265–271.CrossRefGoogle ScholarPubMed
46.Yoshioka, M, Bradley, WG, Shapshak, P, et al.Role of immune activation and cytokine expression in HIV-1–associated neurologic diseases. Adv Neuroimmunol. 1995;5:335–358.CrossRefGoogle ScholarPubMed
47.Simpson, DM, Tagliati, M. Neuromuscular syndromes in human immunodeficiency virus disease. In: Berger, JR, Levy, RM, eds. AIDS and the Nervous System. New York, NY: Lippincott-Raven; 1997:189–222.Google Scholar
48.Shapshak, P, Nagano, I, Xin, K, et al.HIV-1 heterogeneity and cytokines: neuropathogenesis. Adv Exp Med Biol. 1995;373:225–238.CrossRefGoogle ScholarPubMed
49.Nagano, I, Shapshak, P, Yoshioka, M, et al.Increased NADPH-diaphorase reactivity and cytokine expression in dorsal root ganglia in acquired immunodeficiency syndrome. J Neurol Sci. 1996;136:117–128.CrossRefGoogle ScholarPubMed
50.Levy, RM, Bredesen, DE, Rosenblum, ML. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J Neurosurg. 1985;62:475–495.CrossRefGoogle ScholarPubMed
51.Lanska, MJ, Lanska, DJ, Schmidley, JW. Syphilitic polyradiculopathy in an HIV-positive man. Neurology. 1988;38:1297–1301.CrossRefGoogle Scholar
52.Chen, CH, Vazquez-Padua, M, Cheng, YC. Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity. Mol Pharmacol. 1991;39:625–628.Google ScholarPubMed
53.Chattha, G, Arieff, AI, Cummings, C, et al.Lactic acidosis complicating the acquired immunodeficiency syndrome. Ann Intern Med. 1993;118:37–39.CrossRefGoogle ScholarPubMed
54.Verma, A, Schein, RM, Jayaweera, DT, Kett, DA. Fulminant neuropathy and lactic acidosis associated with nucleoside analog therapy. Neurology. 1999;53:1365–1367.CrossRefGoogle ScholarPubMed
55.Cornblath, DR, McArthur, JC, Kennedy, PG, et al.Inflammatory demyelinating peripheral neuropathies associated with human T-cell lymphotropic virus type III infection. Ann Neurol. 1987;21:32–40.CrossRefGoogle ScholarPubMed
56.Snider, WD, Simpson, DM, Nielsen, S, et al.Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann Neurol. 1983;14:403–418.CrossRefGoogle ScholarPubMed
57.Yarchoan, R, Berg, G, Brouwers, P, et al.Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine. Lancet. 1987;1:132–135.CrossRefGoogle Scholar
58.Childs, EA, Lyles, RH, Selnes, OA, et al.Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy. Neurology. 1999;52:607–613.CrossRefGoogle ScholarPubMed