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Equine osteoarthritis: a brief review of the disease and its causes

Published online by Cambridge University Press:  09 March 2007

Angela E Schlueter  and
Michael W Orth
Angela E Schlueter
Affiliation:
Department of Animal Science, Michigan State University, 2209F Anthony Hall, East Lansing, MI 48824, USA
Michael W Orth*
Affiliation:
Department of Animal Science, Michigan State University, 2209F Anthony Hall, East Lansing, MI 48824, USA
*
* Email:orthm@msu.edu
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Abstract

Degenerative joint diseases, such as osteoarthritis, adversely impact the health of the equine athlete as well as the economics of the equine industry. Our understanding of the aetiology of osteoarthritis, although not nearly exhaustive, has increased substantially in recent years. Molecules, including cytokines, inflammatory mediators, and metalloproteinases, have been identified and associated with the progression of joint disease. Several factors, including trauma to the joint, immobilization, conformation, shoeing, and ageing, have been linked with osteoarthritis. Our continued efforts into elucidating critical biological mediators and risk factors, coupled with better chondroprotective therapies and diagnostic tools, should facilitate our ability to maintain the skeletal health of the equine athlete

Keywords

cytokinesmetalloproteinasesjoint diseaserisk factors

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Type
Review Article
Information
Equine and Comparative Exercise Physiology , Volume 1 , Issue 4 , November 2004 , pp. 221 - 231
Copyright
Copyright © Cambridge University Press 2004

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