The nature and mechanisms of plasticity

doi:10.1017/CBO9780511544903.002

1 - The nature and mechanisms of plasticity

Published online by Cambridge University Press: 12 August 2009

Mengia-S. Rioult-Pedotti and

John P. Donoghue

Edited by

Simon Boniface and

Ulf Ziemann

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Mengia-S. Rioult-Pedotti: Affiliation:
Department of Neuroscience, Brown University, Providence, RI, USA
John P. Donoghue: Affiliation:
Department of Neuroscience, Brown University, Providence, RI, USA
Simon Boniface: Affiliation:
Addenbrooke's Hospital, Cambridge
Ulf Ziemann: Affiliation:
Johann Wolfgang Goethe-Universität Frankfurt

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Summary

Cortical map plasticity

It is now well established that the functional organization of the cerebral cortex is plastic, that is, changes in organization occur throughout life in response to normal as well as abnormal experience. The potential for reorganization has been demonstrated in both sensory and motor areas of adult cortex, either as a consequence of trauma, pathological changes, manipulation of sensory experience, or learning. These changes can only be evaluated with reference to an extensive experimental base that has identified a repeatable representation pattern (e.g. somatotopy, tonotopy, or retinotopy), for which change can be detected. While the scope of changes are often at the edge of our technical capabilities to assess, there are striking examples of significant and rapid change (for reviews, see Sanes & Donoghue, 2000; Buonomano & Merzenich, 1998). There is an overwhelming belief that modifications in cortical organization emerge through changes in synaptic efficacy within the cortex and elsewhere in the nervous system. Further, these changes are have been closely linked to the phenomena called long-term potentiation (LTP) and long-term depression (LTD). This review deals mainly with the changes that have been detected in the motor cortex and their link to synaptic modification. Some of the most convincing evidence that learning and practice influences cortical organization and that learning operates through LTP/D-mediated mechanisms has come through work in the motor cortex. This work is also of profound significance to the medical community because it implies that the impaired or damaged motor cortex can be restructured through appropriate physical rehabilitation schemes or through pharmacological means that alter mechanisms accounting for LTP/D.

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Type: Chapter
Information: Plasticity in the Human Nervous System
Investigations with Transcranial Magnetic Stimulation
, pp. 1 - 25

DOI: https://doi.org/10.1017/CBO9780511544903.002 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2003

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References

Altman, J. & Das, G. D. (1965). Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol., 124: 319–335CrossRef Google Scholar PubMed

Alvarez-Buylla, A. & Lois, C. (1995). Neuronal stem cells in the brain of adult vertebrates. Stem Cells, 13: 263–272CrossRef Google Scholar PubMed

Aou, S., Oomura, Y., Woody, C. D. & Nishino, H. (1988). Effects of behaviorally rewarding hypothalamic electrical stimulation on intracellularly recorded neuronal activity in the motor cortex of awake monkeys. Brain Res., 439: 31–38CrossRef Google Scholar PubMed

Aou, S., Woody, C. D. & Birt, D. (1992). Changes in the activity of units of the cat motor cortex with rapid conditioning and extinction of a compound eye blink movement. J. Neurosci., 12: 549–559CrossRef Google Scholar PubMed

Aroniadou, V. A. & Keller, A. (1995). Mechanisms of LTP induction in rat motor cortex in vitro. Cereb. Cortex, 5: 353–362CrossRef Google Scholar PubMed

Artola, A. & Singer, W. (1987). Long-term potentiation and NMDA receptors in rat visual cortex. Nature, 330: 649–652CrossRef Google Scholar PubMed

Artola, A., Broecher, S. & Singer, W. (1990). Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex. Nature, 347: 69–72CrossRef Google Scholar PubMed

Atwood, H. L. & Wojitowicz, J. M. (1999). Silent synapses in neural plasticity: current evidence. Learn. Mem., 6: 542–571CrossRef Google Scholar PubMed

Bailey, C. H. & Kandel, E. R. (1993). Structural changes accompanying memory storage. Ann. Rev. Physiol., 55: 397–426CrossRef Google Scholar PubMed

Bannerman, D. M., Good, M. A., Butcher, S. P., Ramsay, M. & Morris, R. G. M. (1995). Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature, 378: 182–186CrossRef Google Scholar PubMed

Baranyi, A. & Feher, O. (1978). Conditioned changes of synaptic transmission in the motor cortex of the cat. Exp. Brain Res., 33: 283–289CrossRef Google Scholar PubMed

Baranyi, A. & Feher, O. (1981). Long-term facilitation of excitatory synaptic transmission in single motor cortical neurons of the cat produced by repetitive pairing of synaptic potentials and action potentials following intracellular stimulation. Neurosci. Lett., 23: 303–308CrossRef Google Scholar PubMed

Baranyi, A., Szente, M. B. & Woody, C. D. (1991). Properties of associative long lasting potentiation induced by cellular conditioning in the motor cortex of conscious cats. Neuroscience, 42: 321–334CrossRef Google Scholar PubMed

Barnes, C. A., Jung, M. W., McNaughton, B. L., Korol, D. L., Andreasson, K. & Worley, P. F. (1994). LTP saturation and spatial learning disruption: effects of task variables and saturation levels. J. Neurosci., 14: 5793–5806CrossRef Google Scholar PubMed

Bliss, T. V. P. (1998). The saturation debate. Science, 281: 1975–1976CrossRef Google Scholar PubMed

Bliss, T. V. P. & Lomo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path. J. Physiol., 232: 331–356CrossRef Google Scholar

Black, J. E., Isaaks, K. R., Anderson, B. J., Alcantara, A. A. & Greenough, W. T. (1990). Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in the cerebral cortex of adult rats. PNAS, 87: 5568–5572CrossRef Google Scholar

Bourgeois, J-P., Goldman-Rakic, P. & Rakic, P. (1999). Formation, elimination, and stabilization of synapses in the primate cerebral cortex. In Cognitive Neuroscience. A Handbook for the Field, 2nd edn, ed. M. S. Gazzaniga, pp. 23–32. Cambridge, MA: MIT Press

Brons, J. & Woody, C. (1980). Long-term changes in excitability of cortical neurons after Pavlovian conditioning and excitation. J. Neurophysiol., 44: 605–615CrossRef Google Scholar

Buetefisch, C. M., Davis, B. C., Wise, S. P.. (2000). Mechanisms of use dependent plasticity in the human motor cortex. PNAS, 97: 3661–3665CrossRef Google Scholar

Buonomano, D. V. & Merzenich, M. M. (1998). Cortical plasticity: from synapses to maps. Ann. Rev. Neurosci., 21: 149–186CrossRef Google Scholar PubMed

Castro, C. A., Silbert, L. H., McNaughton, B. L. & Barnes, C. A. (1989). Recovery of spatial learning deficits after decay of electrically induced synaptic enhancement in the hippocampus. Nature, 342: 545CrossRef Google Scholar PubMed

Cain, D. P., Hargreaves, E. L., Boon, F. & Dennison, Z. (1993). An examination of the relations between hioppocampal long-term potentiation, kindling, afterdischarge, and place learning in the water maze. Hippocampus, 3: 153–163CrossRef Google Scholar PubMed

Castro-Alamancos, M. A., Donoghue, J. P. & Connors, B. W. (1995). Different forms of synaptic plasticity in the somatosensory and the motor areas of the neocortex. J. Neurosci., 15: 5324–5333CrossRef Google Scholar PubMed

Chen, W., Hu, G. Y., Zhou, Y. D. & Wu, C. P. (1994). Two mechanisms underlying the induction of LTP in motor cortex of adult cat in vitro. Exp. Brain Res., 100: 149–154CrossRef Google Scholar PubMed

Chen, C. & Tonegawa, S. (1997). Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain. Annu. Rev. Neurosci., 20: 157–184CrossRef Google Scholar PubMed

Classen, J., Lippert, J., Wise, S. P., Hallet, M. & Cohen, L. G. (1998). Rapid plasticity of human cortical movement representation induced by practice. J. Neurophysiol., 79: 1117–1123CrossRef Google Scholar PubMed

Clugnet, M-C. & LeDoux, J. E. (1990). Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body. J. Neurosci., 10: 2818–2824CrossRef Google Scholar PubMed

Collindridge, G. L., Kehl, S. J. & McLennan, H. (1983). Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J. Physiol. (Lond.), 334: 33–46CrossRef Google Scholar

Comery, T. A., Stamoudis, C. X., Irwin, S. A. & Greenough, W. T. (1996). Increased density of multiple-head dendritic spines on medium-sized spiny neurons of the striatum in rats reared in a complex environment. Neurobiol. Learn. Mem., 66: 93–96CrossRef Google Scholar

Day, M. & Morris, R. G. M. (2001). Memory consolidation and NMDA receptors: discrepancy between genetic and pharmacological approaches. Science, 293: 755aCrossRef Google Scholar PubMed

Doetsch, F., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. (1997). Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci., 17: 5046–5061CrossRef Google Scholar PubMed

Donoghue, J. P. (1995). Plasticity of adult sensorimotor representations. Curr. Opin. Neurobiol., 5: 749–754CrossRef Google Scholar PubMed

Donoghue, J. P., Suner, S. & Sanes, J. N. (1990). Dynamic organization of primary motor cortex output to target muscles in adult rats. II. Rapid reorganization following motor nerve lesion. Exp. Brain Res., 79: 492–503CrossRef Google Scholar

Donoghue, J. P., Hess, G. & Sanes, J. N. (1996). Substrates and mechanisms for learning in motor cortex. In Acquisition of Motor Behavior, ed. J. Bloedel, T. Ebner & S. P. Wise. Cambridge, MA: MIT Press

Dudek, S. M. & Bear, M. F. (1992). Homosynaptic long-term depression and effects of N-methyl-d-aspartate receptor blockade. Proc. Natl Acad. Sci., USA, 89: 4363–4367CrossRef Google Scholar PubMed

Durand, G. M., Kovalchuk, Y. & Konnerth, A. (1996). LTP and functional synapse induction in developing hippocampus. Nature, 381: 71–75CrossRef Google Scholar PubMed

Elgersma, Y. & Silva, A. J. (1999). Molecular mechanisms of synaptic plasticity and memory. Curr. Opin. Neurobiol., 9: 209–213CrossRef Google Scholar PubMed

Engert, F. & Bonhoeffer, T. (1999). Dendritic spine changes associated with hippocampal longterm synaptic plasticity. Nature, 399: 66–70CrossRef Google Scholar

Eriksson, P. S., Perfilieva, E., Bjork-Eriksson, T., Nordborg, C., Peterson, D. A. & Gage, F. H. (1998). Neurogenesis in the adult human hippocampus. Nat. Medicine, 4: 1207CrossRef Google Scholar PubMed

Gandolfo, F., Li, C-S. R., Benda, B. J., Scioppa, Padoa C. & Bizzi, E. (2000). Cortical correlates of learning in monkeys adapting to a new dynamical environment. PNAS, 97: 2259–2263CrossRef Google Scholar PubMed

Geinisman, Y. (2000). Structural synaptic modifications associated with hippocampal LTP and behavioral learning. Cereb. Cortex, 10: 952–962CrossRef Google Scholar PubMed

Gilbert, C. D., Das, A., Ito, M., Kapadia, M. & Westheimer, G. (1996). Spatial integration and cortical dynamics. PNAS, 93: 615–622CrossRef Google Scholar PubMed

Goda, Y. & Stevens, C. F. (1996). Synaptic plasticity: the basis of particular type of learning. Curr. Biol. 6: 375–378CrossRef Google Scholar

Gomperts, S. N., Rao, A., Craig, A. M., Malenka, R. C. & Nicoll, R. A. (1998). Postsynaptically silent synapses in single neuron cultures. Neuron, 21: 1443–1451CrossRef Google Scholar PubMed

Gould, E., McEven, B. S., Tanapat, P., Galea, L. A. & Fuchs, E. (1997). Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J. Neurosci., 17: 2492–2498CrossRef Google Scholar PubMed

Gould, E., Tanapat, P., Hastings, N. B. & Shors, T. J. (1999a). Neurogenesis in the adulthood: a possible role in learning. Trends Cogn. Sci., 3: 186–192CrossRef Google Scholar

Gould, E., Reeves, A. J., Fallah, M., Tanapat, P., Gross, C. G. & Fuchs, E. (1999b). Hippocampal neurogenesis in adult Old World primates. PNAS, 96: 5263–5267CrossRef Google Scholar

Gould, E., Beylin, A., Tanapat, P., Reeves, A. & Shors, T. J. (1999c). Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci., 2: 203–205CrossRef Google Scholar

Gould, E., Reeves, A. J., Graziani, M. S. A. & Gross, C. G. (1999d). Neurogenesis in the neocortex of adult primates. Science, 286: 548–552CrossRef Google Scholar

Grafton, S. T., Mazziotta, J. P., Presty, S., Friston, K. J., Frackowiak, R. S. J. & Phelps, M. E. (1992). Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET. J. Neurosci., 12: 2542–2548CrossRef Google Scholar PubMed

Grant, S. G., O'Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P. & Kandel, E. R. (1992). Impaired longterm potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science, 258: 1903–1910CrossRef Google Scholar

Hallett, M. (2001). Plasticity in the human motor cortex and recovery from stroke. Brain Res. Rev., 36: 169–174CrossRef Google Scholar

He, Y., Janssen, W. G. M. & Morrison, J. H. (1998). Synaptic coexistence of AMPA and NMDA receptors in the rat hippocampus: a postembedding immunogold study. J. Neurosci. Res., 54: 444–4493.0.CO;2-3>CrossRef Google Scholar PubMed

Hebb, D. O. (1949). Organization of Behavior. New York: Wiley

Hess, G. & Donoghue, J. P. (1994). Long-term potentiation of horizontal connections provides a mechanism to reorganize cortical motor maps. J. Neurophysiol., 71: 2543–2547CrossRef Google Scholar PubMed

Hess, G. & Donoghue, J. P. (1996). Long-term depression of horizontal connections in rat motor cortex. Eur. J. Neurosci., 8: 658–665CrossRef Google Scholar PubMed

Hess, G., Aizenman, C. D. & Donoghue, J. P. (1996). Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex. J. Neurophysiol., 75: 1765–1778CrossRef Google Scholar PubMed

Huntley, G. W. (1997). Correlations between patterns of horizontal connectivity and the extent of short-term representational plasticity in rat motor cortex. Cereb. Cortex, 7: 143–156CrossRef Google Scholar

Iriki, A., Pavlides, C., Keller, A. & Asanuma, H. (1989). Long-term potentiation in the motor cortex. Science, 245: 1385–1387CrossRef Google Scholar PubMed

Isaac, J. T., Nicoll, R. A. & Malenka, R. C. (1995). Evidence for silent synapses: implications for the expression of LTP. Neuron, 15: 427–434CrossRef Google Scholar PubMed

Isaac, J. T., Crair, M. C., Nicoll, R. A. & Malenka, R. C. (1997). Silent synapses during development of thalamocortical inputs. Neuron, 18: 269–280CrossRef Google Scholar PubMed

Jacobs, K. M. & Donoghue, J. P. (1991). Reshaping the cortical motor map by unmasking latent intracortical connection. Science, 251: 944–947CrossRef Google Scholar

Jeffrey, K. J. & Morris, R. G. M. (1993). Cumulative LTP in the rat dentate gyrus correlates with, but does not modify, performance in the water maze. Hippocampus, 3: 133–140CrossRef Google Scholar

Jones, T. A., Klintsova, A. Y., Kilman, V. L., Sirevaag, A. M. & Greenough, W. T. (1997). Induction of multiple synapses by experience in the visual cortex of adult rats. Neurobiol. Learn. Mem., 68: 13–20CrossRef Google Scholar PubMed

Kaas, J. H. (1991). Plasticity of sensory and motor maps in adult mammals. Annu. Rev. Neurosci., 14: 137–167CrossRef Google Scholar PubMed

Karni, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R. & Ungerleider, L. G. (1995). Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature, 377: 155–158Google Scholar PubMed

Keller, A. (1993). Intrinsic synaptic organization of the motor cortex. Cereb. Cortex, 3: 430–441CrossRef Google Scholar PubMed

Keller, A., Weintraub, N. D. & Miyashita, E. (1996). Tactile experience determines the organization of movement representations in rat motor cortex. Neuroreport, 7: 2373–2378CrossRef Google Scholar PubMed

Kentros, C., Hargreaves, E., Hawkins, R. D., Kandel, E. R., Shapiro, M. & Muller, R. V. (1998). Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade. Science, 280: 2121–2126CrossRef Google Scholar PubMed

Kirkwood, A. & Bear, M. F. (1994). Homosynaptic long-term depression in the visual cortex. J. Neurosci., 14: 3404–3412CrossRef Google Scholar PubMed

Kirkwood, A., Rioult, M. G. & Bear, M. F. (1996). Experience-dependent modification of synaptic plasticity in visual cortex. Nature, 381: 526–528CrossRef Google Scholar PubMed

Kleim, J. A., Lussing, E., Schwarz, E. R., Comery, T. A., & Greenough, W. T. (1996). Synaptogenesis and fos expression in the motor cortex of adult rat after motor skill learning. J. Neurosci., 16: 4529–4535CrossRef Google Scholar PubMed

Kleim, J. A., Vij, K., Ballard, D. H. & Greenough, W. T. (1997). Learning dependent synaptic modifications in the cerebellar cortex of the adult rat persist at least four weeks. J. Neurosci., 17: 717–721CrossRef Google Scholar PubMed

Kleim, J. A., Barbay, S. & Nudo, R. J. (1998a). Functional reorganization of the rat motor cortex following motor skill learning. J. Neurophysiol., 80: 3321–3325CrossRef Google Scholar

Kleim, J. A., Swain, R. A., Armstrong, K. E., Napper, R. M. A., Jones, T. A. & Greenough, W. T. (1998b). Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning. Neurobiol. Learn. Mem., 69: 274–289CrossRef Google Scholar

Klintsova, A. Y. & Greenough, W. T. (1999). Synaptic plasticity in cortical systems. Curr. Opin. Neurobiol., 9: 203–208CrossRef Google Scholar PubMed

Kornack, D. R. & Racik, P. (1999). Continuation of neurogenesis in the hippocampus of the adult macaque monkey. PNAS, 96: 5768–5773CrossRef Google Scholar PubMed

Korol, D. L., Abel, T. W., Church, L. T., Barnes, C. A. & McNaughton, B. L. (1993). Hippocampal synaptic enhancement and spatial learning in the Morris swim task. Hippocampus, 3: 127–132CrossRef Google Scholar PubMed

Levy, W. B. & Steward, O. (1979). Synapses as associative memory elements in the hippocampal formation. Brain Res., 175: 233–245CrossRef Google Scholar PubMed

Li, H., Weiss, S. R. B., Chuang, D-M., Post, R. M. & Rogawski, M. A. (1998). Bidirectional synaptic plasticity in the rat basolateral amygdala: characterization of an activity–dependent switch sensitive to the presynaptic metabotropic glutamate receptor antagonist 2S-alpha-ethylglutamic acid. J. Neurosci., 18: 1662–1670CrossRef Google Scholar PubMed

Liao, D. N., Hessler, A. & Malinow, R. (1995). Activation of postsynaptically silent synapses during pairing-induced LTP in CA 1 region of hippocampal slice. Nature, 375: 400–404CrossRef Google Scholar

Liao, D., Zhang, X., O'Brien, R., Ehlers, M. D. & Huganir, R. L. (1999). Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nat. Neurosci., 2: 37–43CrossRef Google Scholar PubMed

Lynch, G. S., Dundwiddie, T. & Gribkoff, V. (1977). Heterosynaptic depression: a postsynaptic correlate of long-term potentiation. Nature, 266: 737–739CrossRef Google Scholar PubMed

McBain, C. & Mayer, M. (1994). NMDA receptor structure and function. Physiol. Rev., 74: 723–760CrossRef Google Scholar PubMed

McGaugh, J. L. & Izquierdo, I. (2000). The contribution of pharmacology to research on the mechanisms of memory formation. TIPS, 21: 208–210Google Scholar PubMed

McKernan, M. G. & Shinnick-Gallagher, P. (1997). Fear conditioning induces a lasting potentiation of synaptic currents in vitro. Nature, 390: 607–611CrossRef Google Scholar PubMed

McNaughton, B. L., Barnes, C. A., Rao, G., Baldwin, J. & Rasmussen, M. (1986). Long-term enhancement of hippocampal synaptic transmission and the acquisition of spatial information. J. Neurosci., 6: 563–571CrossRef Google Scholar PubMed

Malenka, R. (1998). Silent synapses in the hippocampus and cortex. In Central Synapses: Quantal Mechanisms and Plasticity., ed. D. S. Faber, H. Korn, S. J. Redman, S. M. Thompson & J. S. Altman, pp. 207–214. Strasbourg, France: Human Frontier Science Program

Malenka, R. C. & Nicoll, R. A. (1997). Silent synapses speak up. Neuron, 19: 552–553CrossRef Google Scholar PubMed

Malenka, R. C. & Nicoll, R. A. (1999). Long-term potentiation – a decade of progress. Science, 285: 1870–1874CrossRef Google Scholar PubMed

Maletic-Savatic, M. & Svoboda, K. S. (1999). Rapid dendritic morphogenesis in CA 1 hippocampal dendrites induced by synaptic activity. Science, 283: 1923–1927CrossRef Google Scholar

Malinow, R. (1998). Silent synapses in three forms of central plasticity. In Central Synapses: Quantal Mechanisms and Plasticity, ed. D. S. Faber, H. Korn, S. J. Redman, S. M. Thompson & J. S. Altman: pp. 226–234. Strasbourg, France: Human Frontier Science Program

Margolis, D. J., Donoghue, J. P., Rioult, M. G. & Rioult-Pedotti, M.-S. (1999). Role of NMDA receptors in skill learning and learning-induced synaptic strengthening. Soc. Neurosci. Abstr., 25: 888Google Scholar

Martin, S. J. & Morris, R. G. M. (2001). Cortical plasticity: it's all the range!Curr. Biol., 11: R57–R59CrossRef Google Scholar PubMed

Martin, S. J., Grimwood, P. D. & Morris, R. G. M. (2000). Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci., 23: 649–711CrossRef Google Scholar PubMed

Marren, S. (1999). Long-term potentiation in the amygdala: a mechanism for emotional learning and memory. TINS, 22: 561–567Google Scholar

Mayer, M. L., Westbrook, G. L. & Guthrie, P. B. (1984). Voltage-dependent block by Mg2 of NMDA responses in spinal cord neurons. Nature, 309: 261–263CrossRef Google Scholar

Mayford, M., Mansuy, I. M., Muller, R. U. & Kandel, E. R. (1997). Memory and behavior: a second generation of genetically modified mice. Curr. Biol., 7: R580–R589CrossRef Google Scholar PubMed

Merzenich, M. M. & Shameshima, K. (1993). Cortical plasticity and memory. Curr. Opin. Neurobiol., 2: 187–196CrossRef Google Scholar

Miller, S. & Mayford, M. (1999). Cellular and molecular mechanisms of memory: the LTP connections. Curr. Opin. Genet. Developm., 9: 333–337CrossRef Google Scholar

Miller, E. K., Erikson, C. A. & Desimone, R. (1996). Neural mechanisms of visual working memory in prefrontal cortex of the macaque. J. Neurosci., 16: 5154–5167CrossRef Google Scholar PubMed

Morris, R. G. M. (1986). Selective impairment of learning and blockade of long-term potentiation by an NMDA receptor antagonist, AP 5. Nature, 319: 774–776CrossRef Google Scholar

Morris, R. G. M. (1989). Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the NMDA receptor antagonist AP 5. J. Neurosci., 9: 3040–3057CrossRef Google Scholar

Moser, E., Moser, M. B. & Andersen, P. (1993). Synaptic potentiation in the rat dentate gyrus during exploratory learning. Neuroreport, 5: 317–320CrossRef Google Scholar PubMed

Moser, M. B., Trommald, M., Egeland, T. & Andersen, P. (1997). Spatial training in a complex environment and isolation alter the spine distribution differently in rat CA 1 pyramidal cells. J. Comp. Neurol., 380: 373–3813.0.CO;2-#>CrossRef Google Scholar

Moser, E. L., Krobert, K. A., Moser, M. B. & Morris, R. G. M. (1998). Impaired spatial learning after saturation of LTP. Science, 281: 2038–2042CrossRef Google Scholar

Moyer, J. R., Thompson, L. T. & Disterhoft, J. F. (1996). Trace eyeblink conditioning increase CA 1 excitability in a transient and learning-specific manner. J Neurosci., 16: 5536–5546CrossRef Google Scholar

Muellbacher, W., Ziemann, U., Boroojerdi, B., Cohen, L. & Hallett, M. (2001). Role of the human motor cortex in rapid motor learning. Exp. Brain Res., 136: 431–438CrossRef Google Scholar PubMed

Muellbacher, W., Ziemann, U., Wissel, J.. (2002). Early consolidation in human primary motor cortex. Nature, 415: 640–644CrossRef Google Scholar PubMed

Nowak, L., Bregestovski, P., Ascher, P., Herbert, A. & Prochiantz, A. (1984). Magnesium gates glutamate-activated channels in mouse central neurons. Nature, 307: 462–465CrossRef Google Scholar

Nudo, R. J., Milliken, G. W., Jenkins, W. M. & Merzenich, M. M. (1996). Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J. Neurosci., 16: 785–807CrossRef Google Scholar PubMed

Nusser, Z. R., Laube, G., Roberts, J. B. D., Molnr, E. & Somogy, P. (1998). Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron, 21: 545–559CrossRef Google Scholar PubMed

Pascual-Leone, A., Grafman, J. & Hallet, M. (1994). Modulation of cortical motor output maps during development of implicit and explicit knowledge. Science, 263: 1287–1289CrossRef Google Scholar PubMed

Plautz, E. J., Milliken, G. W. & Nudo, R. J. (2000). Effects of repetitive motor skill training on movement representations in adult squirrel monkeys: role of use versus learning. Neurobiol. Learn. Mem., 74: 27–55CrossRef Google Scholar PubMed

Petralia, R. S., Esteban, J. A., Wang, Y-X. et al. (1999). Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapse. Nat. Neurosci., 2: 31–36CrossRef Google Scholar

Power, J. M., Thompson, L. T., Moyer, J. R. & Disterhoft, J. F. (1997). Enhanced synaptic transmission in CA 1 hippocampus after eyeblink conditioning. J. Neurophysiol., 78: 1185–1187CrossRef Google Scholar

Rioult-Pedotti, M-S., Friedman, D., Hess, G. & Donoghue, J. P. (1998). Strengthening of horizontal cortical connections following skill learning. Nat. Neurosci., 1: 230–234CrossRef Google Scholar PubMed

Rioult-Pedotti, M-S., Friedman, D. & Donoghue, J. P. (2000). Learning-induced LTP in neocortex. Science, 290: 533–536CrossRef Google Scholar PubMed

Rioult-Pedotti, M-S. & Donoghue, J. P. (2003). Plasticity of the synaptic modification range with extended motor skill training. Submitted

Rioult-Pedotti, M. S. & Donoghue, J. P. (2002). Learning, retention and persistent strengthening of cortical synapses. Soc. Neurosci. Abstr.Google Scholar

Rogan, M. T., Staeubli, U. V. & LeDoux, J. E. (1997). Fear conditioning induces associative long-term potentiation in the amygdala. Nature, 390: 604–607CrossRef Google Scholar PubMed

Roman, F. S., Truchet, B., Marchetti, E., Chaillan, F. A. & Soumireu-Mourat, B. (1999). Correlations between electrophysiological observations of synaptic plasticity modifications and behavioral performance in mammals. Prog. Neurobiol., 58: 61–87CrossRef Google Scholar PubMed

Rousselot, P., Lois, C. & Alvarez-Buylla, A. (1995). Embryonic (PSA) N-CAM reveals chain of migrating neuroblasts between the lateral ventricle and the olfactory bulb of adult mice. J. Comp. Neurol., 351: 51–61CrossRef Google Scholar

Rumpel, S., Hatt, H. & Gottmann, K. (1998). Silent synapses in the developing rat visual cortex: evidence for postsynaptic expression of synaptic plasticity. J. Neurosci., 18: 8863–8874CrossRef Google Scholar PubMed

Saar, D., Grossman, Y. & Barkai, E. (1999). Reduced synaptic facilitation between pyramidal neurons in the piriform cortex after odor learning. J. Neurosci., 19: 8616–8622CrossRef Google Scholar PubMed

Sakimura, K., Kutsuwada, T., Ito, I.. (1995). Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature, 373: 151–155CrossRef Google Scholar PubMed

Sanes, J. N. & Donoghue, J. P. (1997). Static and dynamic organization of motor cortex. Adv. Neurol., 73: 277–296Google Scholar PubMed

Sanes, J. N. & Donoghue, J. P. (2000). Plasticity and primary motor cortex. Ann. Rev. Neurosci., 23: 393–415CrossRef Google Scholar PubMed

Sanes, J. N., Suner, S., Lando, J. F. & Donoghue, J. P. (1988). Rapid reorganization of adult rat motor cortex somatic representation patterns after motor nerve injury. PNAS, 85: 2003–2007CrossRef Google Scholar PubMed

Sanes, J. N., Suner, S. & Donoghue, J. P. (1990). Dynamic organization of primary motor cortex output to target muscles in adult rats. I. Long-term patterns of reorganization following motor or mixed peripheral nerve lesions. Exp. Brain Res., 79: 479–491CrossRef Google Scholar PubMed

Sanes, J. N., Wang, J. & Donoghue, J. P. (1992). Immediate and delayed changes of rat motor cortical output representation with new forelimb configurations. Cereb. Cortex, 2: 141–152CrossRef Google Scholar PubMed

Saucier, D. & Cain, D. P. (1995). Spatial learning without NMDA receptor-dependent long-term potentiation. Nature, 378: 186–189CrossRef Google Scholar PubMed

Shimizu, E., Tang, Y-P., Rampon, C. & Tsien, J. Z. (2000). NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science, 290: 1170–1174CrossRef Google Scholar PubMed

Shors, T. J. & Matzel, L. D. (1997). Long-term potentiation: what's learning got to do with it?Behav. Brain Sci., 20: 597–655CrossRef Google Scholar

Silva, A., Stevens, C. F., Tonegawa, S. & Wang, Y. (1992). Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science, 257: 201–206CrossRef Google Scholar PubMed

Sorra, K. E. & Harris, K. M. (1998). Stability in synapse number and size at 2 hr after long-term potentiation in hippocampal area CA 1. J. Neurosci., 18: 658–671CrossRef Google Scholar

Stevens, C. F. (1998). A million dollar question: does LTP = memory?Neuron, 20: 1–2CrossRef Google Scholar PubMed

Sutherland, R. J., Dringenberg, H. C. & Hoesing, J. M. (1993). Induction of long-term potentiation at perforant path dentate synapses does not affect place learning or memory. Hippocampus, 3: 141–147CrossRef Google Scholar PubMed

Tang, Y-P., Shimizu, E., Dube, G. R.. (1999). Genetic enhancement of learning and memory in mice. Nature, 401: 63–69CrossRef Google Scholar PubMed

Teskey, G. C., Monfils, M-H., VandenBerg, P. M. & Kleim, J. A. (2002). Motor map expansion following repeated cortical and limbic seizures is related to synaptic potentiation. Cereb. Cortex, 12: 98–105CrossRef Google Scholar PubMed

Thiels, E., Barrionuevo, G. & Berger, T. W. (1994). Excitatory stimulation during postsynaptic inhibition induces long-term depression in hippocampus in vivo. J. Neurophysiol., 72: 3009–3016CrossRef Google Scholar PubMed

Thompson, L. T., Moyer, J. R. & Disterhoft, J. F. (1996). Transient changes in excitability of rabbit CA 3 neurons with a time course appropriate to support memory consolidation. J. Neurophysiol., 76: 1836–1849CrossRef Google Scholar

Toni, N., Buchs, P-A., Nikonenko, I., Bron, C. R. & Mueller, D. (1999). LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature, 402: 421–425CrossRef Google Scholar

Trepel, C. & Racine, R. I., (1998). LTP in the neocortex of the adult, freely moving rat. Cereb. Cortex, 8: 719–729CrossRef Google Scholar

Tsien, J. Z., Huerta, P. T. & Tonegawa, S. (1996). The essential role of hippocampal CA 1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell, 87: 1327–1338CrossRef Google Scholar

Turner, A. M. & Greenough, W. T. (1985). Differential rearing effects on rat visual cortex synapses, I. Synaptic and neuronal density and synapses per neuron. Brain Res., 329: 195–203CrossRef Google Scholar PubMed

Villareal, D. M., Do, V., Haddad, E. & Derrick, B. E. (2002). NMDA receptor antagonists sustain LTP and spatial memory: active processes mediate LTP decay. Nat. Neurosci., 5: 48–52CrossRef Google Scholar

Woody, C. D. (1986). Understanding the cellular basis of memory and learning. Annu. Rev. Psychol., 37: 433–493CrossRef Google Scholar PubMed

Wu, G-Y., Malinow, R. & Cline, H. T., (1996). Maturation of a central glutamatergic synapse. Science, 274: 972–976CrossRef Google Scholar PubMed

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