New questions

doi:10.1017/CBO9780511544903.013

12 - New questions

Published online by Cambridge University Press: 12 August 2009

Mark Hallett ,

Eric M. Wassermann and

Leonardo G. Cohen

Edited by

Simon Boniface and

Ulf Ziemann

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Mark Hallett: Affiliation:
NINDS, NIH, Bethesda, MD, USA
Eric M. Wassermann: Affiliation:
NINDS, NIH, Bethesda, MD, USA
Leonardo G. Cohen: Affiliation:
NINDS, NIH, Bethesda, MD, USA
Simon Boniface: Affiliation:
Addenbrooke's Hospital, Cambridge
Ulf Ziemann: Affiliation:
Johann Wolfgang Goethe-Universität Frankfurt

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Summary

The future is ever a misted landscape, no man foreknows it, but at cyclical turns There is a change felt in the rhythm of events

robinson jeffers Prescription of Painful Ends (l. 3–4). Oxford Book of American Verse, The. F.O. Matthiessen, ed. (1950) Oxford University Press.

The 1990s have witnessed a dramatic burst of knowledge about plasticity. Understanding the importance of plasticity and mechanisms of plasticity and the use of transcranial magnetic stimulation (TMS) as a tool to study human biology have developed at about the same time. It is clear from this book that contributions from TMS studies to plasticity have been enormous. What are the prospects for the future? It is impossible to know exactly what will happen. Simple extrapolations from what is happening now are relatively obvious, and to some extent have been noted in the earlier chapters. There may be new discoveries that will change directions.

It is clear that TMS will not be the only tool to study plasticity, many different techniques will play a role in both basic science and human investigations. For human studies, neuroimaging is very powerful, and EEG and MEG will likely play a greater role to improve time resolution. TMS will likely continue to be used to study the physiology of plasticity, but the bigger growth area may well be in the use of TMS to influence plasticity. Such uses may well expand to therapeutics. These are the topics that we will consider in some more detail.

Information

Type: Chapter
Information: Plasticity in the Human Nervous System
Investigations with Transcranial Magnetic Stimulation
, pp. 288 - 300

DOI: https://doi.org/10.1017/CBO9780511544903.013 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2003

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References

Abraham, W. C. & Tate, W. P. (1997). Metaplasticity: a new vista across the field of synaptic plasticity. Prog. Neurobiol., 52: 303–323CrossRef Google Scholar PubMed

Abraham, W. C., Mason-Parker, S. E., Bear, M. F., Webb, S. & Tate, W. P. (2001). Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP. Proc. Natl Acad. Sci., USA, 98: 10924–10929CrossRef Google Scholar PubMed

Berardelli, A., Inghilleri, M., Rothwell, J. C.. (1998). Facilitation of muscle evoked responses after repetitive cortical stimulation in man. Exp. Brain Res., 122: 79–84CrossRef Google Scholar PubMed

Birbaumer, N., Lutzenberger, W., Montoya, P.. (1997). Effects of regional anesthesia on phantom limb pain are mirrored in changes in cortical reorganization. J. Neurosci., 17: 5503–5508CrossRef Google Scholar PubMed

Boroojerdi, B., Bushara, K. O., Corwell, B.. (2000). Enhanced excitability of the human visual cortex induced by short-term light deprivation. Cereb. Cortex, 10: 529–534CrossRef Google Scholar PubMed

Bütefisch, C. M., Khurana, V., Davis, B., Kopylev, L. & Cohen, L. G. (1999). Modulation of use-dependent plasticity in human motor cortex. Soc. Neurosci. Abstr., 25: 384Google Scholar

Bütefisch, C. M., Davis, B. C., Wise, S. P.. (2000). Mechanisms of use-dependent plasticity in the human motor cortex. Proc. Natl Acad. Sci., USA, 97: 3661–3665CrossRef Google Scholar PubMed

Bütefisch, C. M., Davis, B. C., Sawaki, L.. (2002). Modulation of use-dependent plasticity by d-amphetamine. Ann. Neurol., 51: 59–68CrossRef Google Scholar PubMed

Chen, R., Classen, J., Gerloff, C.. (1997). Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology, 48: 1398–1403CrossRef Google Scholar PubMed

Classen, J., Liepert, J., Wise, S. P., Hallett, M. & Cohen, L. G. (1998). Rapid plasticity of human cortical movement representation induced by practice. J. Neurophysiol., 79: 1117–1123CrossRef Google Scholar PubMed

Cohen, L. G., Celnik, P., Pascual-Leone, A.. (1997). Functional relevance of cross-modal plasticity in blind humans. Nature, 389: 180–183CrossRef Google Scholar PubMed

Conforto, A. B., Kaelin-Lang, A. & Cohen, L. G. (2002). Increase in hand muscle strength of stroke patients after somatosensory stimulation. Ann. Neurol., 51: 122–125CrossRef Google Scholar PubMed

Flor, H., Elbert, T., Knecht, S.. (1995). Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature, 375: 482–484CrossRef Google Scholar PubMed

Flor, H., Elbert, T., Muhlnickel, W., Pantev, C., Wienbruch, C. & Taub, E. (1998). Cortical reorganization and phantom phenomena in congenital and traumatic upper-extremity amputees. Exp. Brain Res., 119: 205–212CrossRef Google Scholar PubMed

George, M. S., Wassermann, E. M., Williams, W. A.. (1995). Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. Neuroreport, 6: 1853–1856CrossRef Google Scholar PubMed

George, M. S., Nahas, Z., Molloy, M.. (2000). A controlled trial of daily left prefrontal cortex TMS for treating depression. Biol. Psychiatry, 48: 962–970CrossRef Google Scholar PubMed

Ghabra, M. B., Hallett, M. & Wassermann, E. M. (1999). Simultaneous repetitive transcranial magnetic stimulation does not speed fine movement in PD. Neurology, 52: 768–770CrossRef Google Scholar

Hamdy, S., Rothwell, J. C., Aziz, Q., Singh, K. D. & Thompson, D. G. (1998). Long-term reorganization of human motor cortex driven by short-term sensory stimulation. Nat. Neurosci., 1: 64–68CrossRef Google Scholar PubMed

Hilgetag, C. C., Theoret, H. & Pascual-Leone, A. (2001). Enhanced visual spatial attention ipsilateral to rTMS-induced ‘virtual lesions’ of human parietal cortex. Nat. Neurosci., 4: 953–957CrossRef Google Scholar PubMed

Hoffman, R. E., Boutros, N. N., Hu, S., Berman, R. M., Krystal, J. H. & Charney, D. S. (2000). Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet, 355: 1073–1075CrossRef Google Scholar

Iriki, A., Pavlides, C., Keller, A. & Asanuma, H. (1991). Long-term potentiation of thalamic input to the motor cortex induced by coactivation of thalamocortical and corticocortical afferents. J. Neurophysiol., 65: 1435–1441CrossRef Google Scholar PubMed

Keck, M. E., Sillaber, I., Ebner, K.. (2000). Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain. Eur. J. Neurosci., 12: 3713–3720CrossRef Google Scholar PubMed

Klein, E., Kreinin, I., Chistyakov, A.. (1999). Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression: a double-blind controlled study. Arch. Gen. Psychiatry, 56: 315–320CrossRef Google Scholar PubMed

Kosslyn, S. M., Pascual-Leone, A., Felician, O.. (1999). The role of area 17 in visual imagery: convergent evidence from PET and rTMS. Science, 284: 167–170CrossRef Google Scholar PubMed

McNamara, B., Ray, J. L., Arthurs, J. & Boniface, S. (2001). Transcranial magnetic stimulation for depression and other psychiatric disorders. Psychol. Med., 31: 1141–1146CrossRef Google Scholar PubMed

Modugno, N., Nakamura, Y., MacKinnon, C. D.. (2001). Motor cortex excitability following short trains of repetitive magnetic stimuli. Exp. Brain Res., 140: 453–459CrossRef Google Scholar PubMed

Pascual-Leone, A., Houser, C. M., Reese, K.. (1993). Safety of rapid-rate transcranial magnetic stimulation in normal volunteers. Electroencephalogr. Clin. Neurophysiol., 89: 120–130CrossRef Google Scholar PubMed

Pascual-Leone, A., Valls-Solé, J., Brasil-Neto, J., Cammarota, A., Grafman, J. & Hallett, M. (1994a). Akinesia in Parkinson's Disease. II. Effects of subthreshold repetitive transcranial motor cortex stimulation. Neurology, 44: 892–898CrossRef Google Scholar

Pascual-Leone, A., Valls-Solé, J., Wassermann, E. M. & Hallett, M. (1994b). Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain, 117: 847–858CrossRef Google Scholar

Pons, T. P. (1998). Reorganizing the brain. Nat. Med., 4: 561–562CrossRef Google Scholar

Ramachandran, V. S., Stewart, M. & Rogers-Ramachandran, D. C. (1992). Perceptual correlates of massive cortical reorganization. Neuroreport, 3: 583–586CrossRef Google Scholar PubMed

Ridding, M. C. & Rothwell, J. C. (1997). Stimulus/response curves as a method of measuring motor cortical excitability in man. Electroencephalogr. Clin. Neurophysiol., 105: 340–344CrossRef Google Scholar PubMed

Roth, B. J., Maccabee, P. J., Eberle, L. P.. (1994). In vitro evaluation of a 4-leaf coil design for magnetic stimulation of peripheral nerve. Electroencephalogr. Clin. Neurophysiol., 93: 68–74CrossRef Google Scholar PubMed

Samii, A., Chen, R., Wassermann, E. M. & Hallett, M. (1998). Phenytoin does not influence postexercise facilitation of motor evoked potentials. Neurology, 50: 291–293CrossRef Google Scholar

wSanger, T. D., Garg, R. R. & Chen, R. (2001). Interactions between two different inhibitory systems in the human motor cortex. J. Physiol., 530: 307–317CrossRef Google Scholar PubMed

Sawaki, L., Boroojerdi, B., Kaelin-Lang, A.. (2002). Cholinergic influences on use-dependent plasticity. J. Neurophysiol., 87: 166–171CrossRef Google Scholar PubMed

Shimamoto, H., Morimitsu, H., Sugita, S., Nakahara, K. & Shigemori, M. (1999). Therapeutic effect of repetitive transcranial magnetic stimulation in Parkinson's disease. Rinsho Shinkeigaku, 39: 1264–1267Google Scholar PubMed

Siebner, H. R., Mentschel, C., Auer, C. & Conrad, B. (1999a). Repetitive transcranial magnetic stimulation has a beneficial effect on bradykinesia in Parkinson's disease. Neuroreport, 10: 589–594CrossRef Google Scholar

Siebner, H. R., Tormos, J. M., Ceballos-Baumann, A. O.. (1999b). Low-frequency repetitive transcranial magnetic stimulation of the motor cortex in writer's cramp. Neurology, 52: 529–537CrossRef Google Scholar

Siebner, H. R., Rossmeier, C., Mentschel, C., Peinemann, A. & Conrad, B. (2000). Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease. J. Neurol. Sci., 178: 91–94CrossRef Google Scholar PubMed

Sommer, M., Tergau, F., Wischer, S. & Paulus, W. (2001). Paired-pulse repetitive transcranial magnetic stimulation of the human motor cortex. Exp. Brain Res., 139: 465–472CrossRef Google Scholar PubMed

Speer, A. M., Kimbrell, T. A., Wassermann, E. M.. (2000). Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol. Psychiatry, 48: 1133–1141CrossRef Google Scholar PubMed

Stefan, K., Kunesch, E., Cohen, L. G., Benecke, R. & Classen, J. (2000). Induction of plasticity in the human motor cortex by paired associative stimulation. Brain, 123: 572–584CrossRef Google Scholar PubMed

Tergau, F., Naumann, U., Paulus, W. & Steinhoff, B. J. (1999). Low-frequency repetitive transcranial magnetic stimulation improves intractable epilepsy. Lancet, 353: 2209CrossRef Google Scholar PubMed

Touge, T., Gerschlager, W., Brown, P. & Rothwell, J. C. (2001). Are the after-effects of low-frequency rTMS on motor cortex excitability due to changes in the efficacy of cortical synapses?Clin. Neurophysiol., 112: 2138–2145CrossRef Google Scholar PubMed

Triggs, W. J., McCoy, K. J., Greer, R.. (1999). Effects of left frontal transcranial magnetic stimulation on depressed mood, cognition, and corticomotor threshold. Biol. Psychiatry, 45: 1440–1446CrossRef Google Scholar PubMed

Wassermann, E. M. & Lisanby, S. H. (2001). Therapeutic application of repetitive transcranial magnetic stimulation: a review. Clin. Neurophysiol., 112: 1367–1377CrossRef Google Scholar PubMed

Wassermann, E. M., Grafman, J., Berry, C.. (1996). Use and safety of a new repetitive transcranial magnetic stimulator. Electroencephalogr. Clin. Neurophysiol., 101: 412–417CrossRef Google Scholar PubMed

Wu, T., Sommer, M., Tergau, F. & Paulus, W. (2000). Lasting influence of repetitive transcranial magnetic stimulation on intracortical excitability in human subjects. Neurosci. Lett., 287, 37–40CrossRef Google Scholar PubMed

Yang, T. T., Gallen, C. C., Ramachandran, V. S., Cobb, S., Schwartz, B. J. & Bloom, F. E. (1994). Noninvasive detection of cerebral plasticity in adult human somatosensory cortex. Neuroreport, 5: 701–704CrossRef Google Scholar PubMed

Yaroslavsky, Y., Grisaru, N., Chudakov, B. & Belmaker, R. H. (1999). Is TMS therapeutic in mania as well as in depression?Electroencephalogr. Clin. Neurophysiol. Suppl., 51: 299–303Google Scholar PubMed

Ziemann, U., Corwell, B. & Cohen, L. G. (1998a). Modulation of plasticity in human motor cortex after forearm ischemic nerve block. J. Neurosci., 18: 1115–1123CrossRef Google Scholar

Ziemann, U., Hallett, M. & Cohen, L. G. (1998b). Mechanisms of deafferentation-induced plasticity in human motor cortex. J. Neurosci., 18xs: 7000–7007CrossRef Google Scholar

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