This integrative chapter highlights the interdisciplinary implications of the book’s core arguments. It synthesises the historical, neuroscientific, cultural, and ethical perspectives covered in earlier chapters, showing how they converge around a central theme: the human impulse to reshape consciousness through external means. The summary identifies key throughlines such as the neurochemical basis of thrill-seeking, the symbolic encoding of drug use, the commodification of altered states, and the rise of digital simulation as a new frontier of mind alteration. It stresses the importance of cross-disciplinary collaboration in addressing emerging challenges — including addiction, mental health, identity fragmentation, and regulatory vacuums. The chapter proposes that future research and policy must account for the hybrid nature of cognitive environments, shaped by both chemical inputs and algorithmic systems. Ultimately, it reaffirms the need to develop new cultural literacies and ethical frameworks suited to the complexities of the digital-chemical age.