Host–Pathogen Interactions

doi:10.1017/CBO9780511976094.032

32 - Host–Pathogen Interactions

from Part II - Cell Death in Tissues and Organs

Published online by Cambridge University Press: 07 September 2011

Edited by

Douglas R. Green: Affiliation:
St. Jude Children's Research Hospital, Memphis, Tennessee
Maya Saleh: Affiliation:
McGill University
John C. Reed: Affiliation:
Sanford-Burnham Medical Research Institute, La Jolla, California

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Summary

Introduction

In this chapter, I address the fundamental questions of what differentiates pathogens from commensal microorganisms and how pathogens succeed in causing infectious disease. I delve in more detail into host mechanisms evolved to detect the presence of invaders and to fight infections. I focus on the role of innate immunity, production of antimicrobial peptides, inflammation, and cell death in the host–pathogen battle and discuss the remarkable conservation of innate immunity between plants, invertebrates, and mammals, despite having evolved under selective pressure imposed by distinct pathogens.

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Type: Chapter
Information: Apoptosis
Physiology and Pathology
, pp. 372 - 388

DOI: https://doi.org/10.1017/CBO9780511976094.032 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2011

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