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7 - Therapeutic decision making in BMT/SCT for myelodysplasia

Published online by Cambridge University Press:  05 August 2013

By
Carolina Escobar ,
Reinhold Munker  and
Kerry Atkinson
Edited by
Reinhold Munker ,
Gerhard C. Hildebrandt ,
Hillard M. Lazarus  and
Kerry Atkinson
Reinhold Munker
Affiliation:
Louisiana State University, Shreveport
Gerhard C. Hildebrandt
Affiliation:
University of Utah
Hillard M. Lazarus
Affiliation:
Ireland Cancer Center, Case Western Reserve University Hospital, Cleveland
Kerry Atkinson
Affiliation:
University of Queensland
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Summary

MDS constitutes a group of clonal hematopoietic stem cell disorders occurring often in the elderly that are characterized by cytopenias and cytogenetic abnormalities, and can evolve into AML. The prevalence and incidence of MDS have increased in the last 20 years, likely as a result of increasing longevity of the population. These disorders are heterogeneous and staged and classified according to the percentage of blasts in the bone marrow, cytogenetic abnormalities, and number of cytopenias. As shown on pages 78–79, several staging systems are available. The International Prognostic Scoring System (IPSS) will divide cases of MDS into groups according to survival and risk for leukemia transformation. The disadvantage of this scoring system is that it does not take into account age, ferritin, transfusion dependence, and marrow fibrosis. There are other scoring systems like the WHO Prognostic Scoring System for OS and relapse. A revised scoring system is currently under development (Appelbaum et al., 2011).

Type
Chapter
Information
The BMT Data Book
Including Cellular Therapy
 , pp. 77 - 89
Publisher: Cambridge University Press
Print publication year: 2013

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References

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