1. , . Pathophysiology of cerebral ischemia and brain trauma: similarities and differences. J Cereb Blood Flow Metab 2004;24:133–50.
2. , , , et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993;34:216–22.
3. , , , et al. Harbingers of poor outcome the day after severe brain injury: hypothermia, hypoxia, and hypoperfusion. J Trauma 2003;54:312–19.
4. , , , et al. Prognostic value of admission blood pressure in traumatic brain injury: results from the IMPACT study. J Neurotrauma 2007;24:294–302.
5. , , , et al. Blood pressure and clinical outcomes in the International Stroke Trial. Stroke 2002;33:1315–20.
6. , , , et al. U-shaped relationship between mortality and admission blood pressure in patients with acute stroke. J Intern Med 2004;255:257–65.
7. , , , et al. Delayed hemorrhagic hypotension exacerbates the hemodynamic and histopathologic consequences of traumatic brain injury in rats. J Cereb Blood Flow Metab 2001;21:847–56.
8. , , , et al. Acute, transient hemorrhagic hypotension does not aggravate structural damage or neurologic motor deficits but delays the long-term cognitive recovery following mild to moderate traumatic brain injury. Crit Care Med 2006;34:492–501.
9. , , , et al. Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism. J Cereb Blood Flow Metab 2003;23:1239–50.
10. , , , et al. Traumatic brain injury and hemorrhagic hypotension suppress neuroprotective gene expression in injured hippocampal neurons. Anesthesiology 2005;102:806–14.
11. . The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 2011;17:439–47.
12. , , , et al. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab 2011;31:17–35.
13. , , , et al. Recurrent spreading depolarizations after subarachnoid hemorrhage decreases oxygen availability in human cerebral cortex. Ann Neurol 2010;67:607–17.
14. , , , et al. Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range. J Cereb Blood Flow Metab 2010;30:1168–77.
15. , . Relationship between cardiac output and cerebral blood flow in patients with intact and with impaired autoregulation. J Neurosurg 1990;73:368–74.
16. , , , et al. Middle cerebral artery blood velocity depends on cardiac output during exercise with a large muscle mass. Acta Physiol Scand 1998;162:13–20.
17. , , , et al. The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. J Physiol 2005;569:697–704.
18. , , , et al. Survival, hemodynamics, and tissue oxygenation after head trauma. J Am Coll Surg 2006;202:120–30.
19. , , , et al. Cardiopulmonary haemodynamic changes after severe head injury. Br J Neurosurg 2004;18:158–63.
20. , , , et al. Increases in cardiac output can reverse flow deficits from vasospasm independent of blood pressure: a study using xenon computed tomographic measurement of cerebral blood flow. Neurosurgery 2003;53:1044–51.
21. , , , et al. Performance of bedside transpulmonary thermodilution monitoring for goal-directed hemodynamic management after subarachnoid hemorrhage. Stroke 2009;40:2368–74.
22. , , , et al. Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study. Anesthesiology 2007;106:687–95.
23. , , , et al. Physiologic and functional outcome correlates of brain tissue hypoxia in traumatic brain injury. Crit Care Med 2009;37:283–90.
24. , , , et al. Brain tissue oxygen-directed management and outcome in patients with severe traumatic brain injury. J Neurosurg 2010;113:571–80.
25. , , , et al. Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans. J Appl Physiol 2008;104:212–17.
26. , , , et al. Hypobaric hypoxia exacerbates the neuroinflammatory response to traumatic brain injury. J Surg Res 2011;165:30–7.
27. , , , et al. Prognostic value of secondary insults in traumatic brain injury: results from the IMPACT study. J Neurotrauma 2007;24:287–93.
28. , , , et al. Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study. J Trauma 2006;61:1134–41.
29. , , . Hypoxemia and arterial hypotension at the accident scene in head injury. J Trauma 1996;40:764–7.
30. , , , et al. Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism. Crit Care Med 2007;35:568–78.
31. , , , et al. Early ventilation and outcome in patients with moderate to severe traumatic brain injury. Crit Care Med 2006;34:1202–8.
32. , , , et al. Inappropriate prehospital ventilation in severe traumatic brain injury increases in-hospital mortality. J Neurotrauma 2010;27:1233–41.
33. , , . A prospective study of the quality of pre-hospital emergency ventilation in patients with severe head injury. Br J Anaesth 2002;88:345–9.
34. , , , et al. Effects of permissive hypercapnia on transient global cerebral ischemia-reperfusion injury in rats. Anesthesiology 2010;112:288–97.
35. , . The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery 2000;46:335–42; discussion 42–3.
36. , . Perioperative glycemic control: an evidence-based review. Anesthesiology 2009;110:408–21.
37. , , , et al. Effects of glucose and PaO2 modulation on cortical intracellular acidosis, NADH redox state, and infarction in the ischemic penumbra. Stroke 1999;30:160–70.
38. , , , et al. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Nat Med 2011;17:206–10.
39. , , , et al. Hyperglycaemia and apoptosis of microglial cells in human septic shock. Crit Care 2011;15:R131.
40. , , , et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345:1359–67.
41. , , , et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009;360:1283–97.
42. , , , et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol 2007;6:397–406.
43. , , , et al. Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocrit Care 2008;9:159–66.
44. , , , et al. Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Crit Care Med 2006;34:850–6.
45. , , , et al. Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg 1997;86:241–51.
46. , , , et al. Transient changes in cortical glucose and lactate levels associated with peri-infarct depolarisations, studied with rapid-sampling microdialysis. J Cereb Blood Flow Metab 2005;25:391–401.
47. , , . Glycemic control in the ICU. Chest 2011;140:212–20.
48. , , , et al. Acute severe isovolemic anemia impairs cognitive function and memory in humans. Anesthesiology 2000;92:1646–52.
49. , , , et al. Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery. Ann Thorac Surg 2005;80:1381–7.
50. , , , et al. Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma. J Appl Physiol 2007;103:1021–9.
51. , , , et al. Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care 2006;5:4–9.
52. , , , et al. Hemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression. J Appl Physiol 2003;94:2058–67.
53. , , . Export by red blood cells of nitric oxide bioactivity. Nature 2001;409:622–6.
54. , , , et al. Anemia and cerebral outcomes: many questions, fewer answers. Anesth Analg 2008;107:1356–70.
55. , , , et al. Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats. Am J Physiol Regul Integr Comp Physiol 2007;292:R403–14.
56. , , , et al. Erythropoietin 2nd cerebral protection after acute injuries: a double-edged sword?Pharmacol Ther 2010;128:445–59.
57. , , . Retrospective evaluation of anemia and transfusion in traumatic brain injury. J Trauma 2006;61:567–71.
58. , , , et al. Complications associated with anemia and blood transfusion in patients with aneurysmal subarachnoid hemorrhage. Crit Care Med 2008;36:2070–5.
59. , , , et al. Red blood cell transfusion increases cerebral oxygen delivery in anemic patients with subarachnoid hemorrhage. Stroke 2009;40:3039–44.
60. . Anemia and transfusion after subarachnoid hemorrhage. Neurocrit Care 2011;15:342–53.
61. , , , et al. Anemia in the setting of traumatic brain injury: the arguments for and against liberal transfusion. J Neurotrauma 2011;28:155–65.
62. , , , et al. Acute encephalopathy with inflammation-mediated status epilepticus. Lancet Neurol 2011;10:99–108.
63. , , , et al. Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proc Natl Acad Sci USA 1999;96:8721–6.
64. , , , et al. Hyperthermia following traumatic brain injury: a critical evaluation. Neurobiol Dis 2003;12:163–73.
65. , , , et al. Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage. J Neurol Neurosurg Psychiatry 2001;71:448–54.
66. , , , et al. Impact of fever on outcome in patients with stroke and neurologic injury: a comprehensive meta-analysis. Stroke 2008;39:3029–35.
67. , , , et al. The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. Lancet Neurol 2009;8:434–40.
68. . Brain temperature homeostasis: physiological fluctuations and pathological shifts. Front Biosci 2010;15:73–92.
69. , , , et al. The effect of spontaneous alterations in brain temperature on outcome: a prospective observational cohort study in patients with severe traumatic brain injury. J Neurotrauma 2010;27:2157–64.
70. , , , et al. Sepsis-associated encephalopathy and its differential diagnosis. Crit Care Med 2009;37:S331–6.
71. , , . Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet 2010;375:773–5.
72. , , , et al. Cerebral microcirculation is impaired during sepsis: an experimental study. Crit Care 2010;14:R140.
73. , , , et al. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 2003;362:1799–805.
74. , , , et al. Brain lesions in septic shock: a magnetic resonance imaging study. Intensive Care Med 2007;33:798–806.