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3 - Dynamic Epigenetic Impact of the Environment on the Developing Brain

from Part I - Foundations

Published online by Cambridge University Press:  26 September 2020

By
Frances A. Champagne
Edited by
Jeffrey J. Lockman  and
Catherine S. Tamis-LeMonda
Jeffrey J. Lockman
Affiliation:
Tulane University, Louisiana
Catherine S. Tamis-LeMonda
Affiliation:
New York University
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Summary

Development is a dynamic process shaped by the interactions between genes and environments. Within the field of developmental biology, the complex interactions between genes and their products that create the foundation for cellular differentiation and the formation of the nervous system have been well described. Advances in molecular biology have permitted increasing precision in the characterization of the cascade of molecular changes that link genes to specific developmental endpoints. However, beyond addressing questions regarding the processes linking a gene to a phenotypic outcome, description of these molecular changes has also provided insight into the ways in which the environment induces lasting biological effects. Though environments – particularly characteristics of the social world around us – are typically viewed as a separate and distinct influence from genes, there is increasing understanding of the interplay between genes and environments.

Keywords

Epigeneticsgene-environment interactionsDNA methylationbrain developmentmaternal stress
Type
Chapter
Information
The Cambridge Handbook of Infant Development
Brain, Behavior, and Cultural Context
 , pp. 70 - 93
Publisher: Cambridge University Press
Print publication year: 2020

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