Skip to main content Accessibility help
×
Hostname: page-component-76fb5796d-qxdb6 Total loading time: 0 Render date: 2024-04-26T05:23:25.666Z Has data issue: false hasContentIssue false

2 - The Biomedical Bases of Successful Aging

Published online by Cambridge University Press:  10 January 2019

Rocío Fernández-Ballesteros
Affiliation:
Universidad Autónoma de Madrid
Athanase Benetos
Affiliation:
Université de Lorraine and Institut national de la santé et de la recherche médicale (INSERM) Nancy
Jean-Marie Robine
Affiliation:
INSERM
Get access

Summary

Life expectancy at birth increased by more than 30 years during the last century. However, maximal life span increased little during the last centuries indicating that there is a limit in the maximal life expectancy of the human species. The respective roles of and interactions between genes, environment and stochastic factors determine the pace of the aging process. The important progress in the biomedical domain contributes in the development of strategies for the prevention of the functional decline and the frailty process, thereby increasing the probability of successful aging. However, it is rather illusory that these actions may alter the limits of human maximum longevity and stop the ageing process.
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Berrut, G., Andrieu, S., Araujo de Carvalho, I., et al. Promoting access to innovation for frail old persons. IAGG (International Association of Gerontology and Geriatrics), WHO (World Health Organization) and SFGG (Societe Francaise de Geriatrie et de Gerontologie) Workshop – Athens January 20–21, 2012. J Nutr Health Aging. 2013; 17: 688–93.CrossRefGoogle Scholar
Ferrucci, L., Guralnik, J. M., Studenski, S., et al. Interventions on Frailty Working Group. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc. 2004; 52: 625–34.CrossRefGoogle Scholar
Fried, L. P., Tangen, C. M., Walston, J., et al. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56: 146–56.CrossRefGoogle ScholarPubMed
Heutling, D., Lehnert, H. Hormone therapy and anti-aging: Is there an indication? Internist (Berl). 2008; 49: 572–9.Google ScholarPubMed
Krause, D., Roupas, P. Effect of vitamin intake on cognitive decline in older adults: Evaluation of the evidence. J Nutr Health Aging. 2015; 19: 745–53.CrossRefGoogle ScholarPubMed
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., Kroemer, G. The hallmarks of aging. Cell. 2013; 153: 1194–217.CrossRefGoogle ScholarPubMed
López-Otín, C., Galluzzi, L., Freije, J. M., Madeo, F., Kroemer, G. Metabolic control of longevity. Cell. 2016; 166: 802–21.CrossRefGoogle ScholarPubMed
Pincemail, J., Ricour, C., Defraigne, J. O., Petermans, J. Oxidative stress, antioxidants and the ageing process. Rev Med Liege. 2014; 69: 270–5.Google ScholarPubMed
Robine, J.-M. La révolution de la longévité des adultes. Gerontologie et Société. 2016; 39: 2140.CrossRefGoogle Scholar
Sansone, A., Sansone, M., Lenzi, A., Romanelli, F. Testosterone replacement therapy: The emperor's new clothes. Rejuvenation Res. 2017; 20: 914.CrossRefGoogle ScholarPubMed
Studenski, S., Perera, S., Patelet, K., et al. Gait speed and survival in older adults. JAMA. 2011; 305: 50–8.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×