1. , , , et al. Cerebral subcortical small vessel disease and its relation to cognition in elderly subjects: a pathological study in the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort. Neuropathol Appl Neurobiol 2012;38:337–343.
2. , , , et al. Intracerebral hemorrhage in the oldest old: a population-based study (Vantaa 85+). Front Neurol 2012;3:103.
3. , , et al. Clinical significance of microbleeds in subcortical vascular dementia. Stroke 2007;38:1949–1951.
4. , , , et al. Cerebral subcortical small vessel disease in subjects with pathologically confirmed Alzheimer’s disease: a clinicopathological study in the Oxford Project to Investigate Memory and Ageing (OPTIMA). Alzheimer Dis Assoc Disord 2013, Jul 8 [Epub ahead of print].
5. , , , et al. Cerebral amyloid angiopathy in the elderly: vessel wall changes and relationship with dementia. Acta Neuropathol 2003;106:367–373.
6. , , Vascular diseases. In , , , eds. Greenfield’s Neuropathology, 8th edn. London: Hodder Arnold; 2008: pp. 121–240.
7. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010;9:689–701.
8. , , , et al. Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Ann Neurol 2005;58:459–462.
9. Cerebral amyloid angiopathy. A critical review. Stroke 1987;18:311–324.
10. , , , Review: sporadic cerebral amyloid angiopathy. Neuropathol Appl Neurobiol 2011;37:75–93.
11. , , , et al. Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann Neurol 1991;30:637–649.
12. . Medical Research Council Cognitive Function and Ageing Study. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 2001;357:169–175.
13. , , Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy: an autopsy study. J Neurol 2008;255:70–76.
14. , , , et al. Variants at ApoE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol 2010;68:934–943.
15. , High frequency of apolipoprotein E ε2 allele is specific for patients with cerebral amyloid angiopathy-related haemorrhage. Neurosci Lett 1998;247:45–48.
16. , , , et al. Association between severe cerebral amyloid angiopathy and cerebrovascular lesions in Alzheimer disease is not a spurious one attributable to apolipoprotein E ε4. Arch Neurol 2000;57:869–874.
17. , , Sporadic cerebral amyloid angiopathy – no frequent cause of spontaneous brain haemorrhage. Neuropathol App Neurobiol 2008;34:S1–14.
18. , , Sporadic cerebral amyloid angiopathy is not a frequent cause of spontaneous brain hemorrhage. Eur J Neurol 2007;14:923–928.
19. , , , et al. Progression of white matter lesions and hemorrhages in cerebral amyloid angiopathy. Neurology 2006;67:83–87.
20. , , , Cerebral microinfarcts: the invisible lesions. Lancet Neurol 2012;11:272–282.
21. , , , et al. Acute ischaemic brain lesions in intracerebral haemorrhage: multicentre cross-sectional magnetic resonance imaging study. Brain 2011;134:2376–2386.
22. , , , et al. Effects of perindopril-based lowering of blood pressure on intracerebral hemorrhage related to amyloid angiopathy: the PROGRESS trial. Stroke 2010;41:394–396.
23. , , , et al. Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies. Acta Neuropathol 2009;118:115–130.
24. , , Apolipoprotein E in Alzheimer’s disease and other neurological disorders. Lancet Neurol 2011;10:241–252.
25. , , , , Apolipoprotein E ε4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 1995;38:254–259.
26. , , , et al. Association of apolipoprotein E ε2 and vasculopathy in cerebral amyloid angiopathy. Neurology 1998;50:961–965.
27. , , , et al. The apolipoprotein E ε2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage. J Neuropathol Exp Neurol 1999;58:711–718.
28. , , , et al. High frequency of apolipoprotein E ε2 allele in hemorrhage due to cerebral amyloid angiopathy. Ann Neurol 1997;41:716–721.
29. , , , et al. Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. N Engl J Med 2000;342:240–245.
30. , , , et al. Apolipoprotein E ε4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. Stroke 1996;27:1333–1337.
31. , , , et al. APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. Lancet Neurol 2011;10:702–709.
32. Genetics of intracerebral haemorrhage: a tsunami effect of APOE ε2 genotype on brain bleeding size? Lancet Neurol 2011;10:673–675.
33. , , Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J Neurol Neurosurg Psychiatry 2012;83:124–137.
34. , Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke 2002;33:831–836.
35. , , , et al. Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-β e22q and l34v mutants, delaying their toxicity for human brain microvascular endothelial cells. J Biol Chem 2010;285:27144–27158.
36. Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurol 2009;8:205–216.
37. , , , et al. Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy. Ann Neurol 2003;54:379–382.
38. Bleeding in the brain: amyloid-β may keep clots away. Nat Med 2009;15:1132–1133.
39. , , , et al. Aβ APP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis. J Neurosci 2009;29:5666–5670.
40. , , , et al. The increasing incidence of anticoagulant-associated intracerebral hemorrhage. Neurology 2007;68:116–121.
41. , , , et al. Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: a systematic review of published and unpublished studies. Stroke 2010;41:1222–1228.
42. , , , Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study. Neurology 2000;55:947–951.
43. , Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage. Lancet Neurol 2004;3:484–492.
44. , , , et al. Clinical features and pathogenesis of intracerebral hemorrhage after RT-PA and heparin therapy for acute myocardial infarction: the Thrombolysis In Myocardial Infarction (TIMI) (ii) pilot and randomized clinical trial combined experience. Neurology 1995;45:649–658.
45. , , , et al. CADASIL: the most common hereditary subcortical vascular dementia. Future Neurol 2008;3:683–704.
46. , , , . Intracerebral hemorrhages in CADASIL. Neurology 2006;67:2042–2044.
47. , , , et al. Atraumatic convexal subarachnoid hemorrhage: clinical presentation, imaging patterns, and etiologies. Neurology 2010;74:893–899.
48. , , , et al. Cortical subarachnoid haemorrhage in the elderly: a recurrent event probably related to cerebral amyloid angiopathy. Eur J Neurol 2011;18:597–603.
49. , , , et al. Subarachnoid hemosiderosis and superficial cortical hemosiderosis in cerebral amyloid angiopathy. AJNR Am J Neuroradiol 2008;29:184–186.
50. , , , et al. Isolated acute nontraumatic cortical subarachnoid hemorrhage. AJNR Am J Neuroradiol 2010;31:1355–1362.
51. , , , et al. A restricted subarachnoid hemorrhage in the cortical sulcus in cerebral amyloid angiopathy: could it be a warning sign? Surg Neurol 2007;68:457–460.
52. , , , , Cerebral amyloid angiopathy with symptomatic or occult subarachnoid haemorrhage. Eur Neurol 2007;57:103–105.
53. , The clinical conundrum of convexal subarachnoid hemorrhage. Neurology 2010;74:874–875.
54. , , , et al. Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. Neurology 2010;74:1346–1350.
55. , , , et al. Clinical presentation, etiology, and long-term prognosis in patients with nontraumatic convexal subarachnoid hemorrhage. Stroke 2011;42:3055–3060.
56. , , Superficial siderosis of the central nervous system. Brain 1995;118 (Pt 4):1051–1066.
57. , , , et al. Superficial siderosis. Neurology 2006;66:1144–1152.
58. , , , et al. Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease. Stroke 2008;39:2894–2897.
59. , , , et al. Superficial siderosis in the general population. Neurology 2009;73:202–205.
60. , , Superficial siderosis: a case report and review of the literature. Nat Clin Pract Neurol 2007;3:54–58; quiz 59.
61. , , , et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 2009;8:165–174.
62. , , , et al. Imaging cerebral amyloid angiopathy with susceptibility-weighted imaging. AJNR Am J Neuroradiol 2007;28:316–317.
63. , . Neuroprotective strategies for intracerebral hemorrhage: trials and translation. Stroke 2010;41:S99–S102.
64. , , , et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 2008;70:1208–1214.
65. , , , et al. MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength. AJNR Am J Neuroradiol 2009;30:338–343.
66. , , , et al. Seven Tesla MRI of microbleeds and white matter lesions as seen in vascular dementia. J Magn Reson Imaging 2011;33:782–791.
67. , , , et al. Visualization of cerebral microbleeds with dual-echo T2*-weighted magnetic resonance imaging at 7.0 T. J Magn Reson Imaging 2010;32:52–59.
68. , , , et al. Comparison of 7.0-T T(2)*-magnetic resonance imaging of cerebral bleeds in postmortem brain sections of Alzheimer patients with their neuropathological correlates. Cerebrovasc Dis 2011;31:511–517.
69. , , , et al. Dynamic temporal change of cerebral microbleeds: long-term follow-up MRI study. PLoS One 2011;6:e25930.
70. , , , MR detection of microhemorrhages in neurologically healthy adults. Neuroradiology 2002;44:31–36.
71. Brain microbleeds: more evidence, but still a clinical dilemma. Curr Opin Neurol 2011;24:69–74.
72. , , , Cerebral microbleeds: a review. Panminerva Med 2012;54:149–160.
73. , , , et al. The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol 2009;24:553–572.
74. Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications. Neurology 2006;66:165–171.
75. , , Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007;130:1988–2003.
76. , , , , CADASIL. Lancet Neurol 2009;8:643–653.
77. , , , et al. Cerebral microbleeds in CADASIL: a gradient-echo magnetic resonance imaging and autopsy study. Stroke 2002;33:67–71.
78. , , , et al. Microbleeds in hereditary cerebral hemorrhage with amyloidosis-Dutch type. Neurology 2005;64:1288–1289.
79. , , , et al. Cerebral microbleeds in the population based ages – Reykjavik study: prevalence and location. J Neurol Neurosurg Psychiatry 2008;79:1002–1006.
80. , , , et al. Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam Scan Study. Stroke 2010;41:S103–106.
81. , , , et al. Cerebral microbleeds and cognitive functioning in the PROSPER study. Neurology 2011;77:1446–1452.
82. , , , et al. MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population. Stroke 2009;40:492–498.
83. , , , et al. Cerebral microbleeds are predictive of mortality in the elderly. Stroke 2011;42:638–644.
84. , , , et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999;20:637–642.
85. , , , , Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas. Stroke 1999;30:1637–1642.
86. , , , et al. Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study. Acta Neuropathol 2010;119:291–302.
87. , Vascular pathology in the aged human brain. Acta Neuropathol 2010;119:277–290.
88. , , , et al. Review of cerebral microangiopathy and Alzheimer’s disease: relation between white matter hyperintensities and microbleeds. Dement Geriatr Cogn Disord 2011;32:367–378.
89. , , Cerebral microbleeds: histopathological correlation of neuroimaging. Cerebrovasc Dis 2011;32:528–534.
90. , , , , Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke 2004;35:1415–1420.
91. , , , Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology 2001;56:537–539.
92. , , , et al. Frequency and location of microbleeds in patients with primary intracerebral hemorrhage. Stroke 2000;31:2665–2669.
93. , , , et al. Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol 2002;61:282–293.
94. , , , et al. Genetic associations with brain microbleeds: systematic review and meta-analyses. Neurology 2011;77:158–167.
95. , , , et al. Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study. Stroke 2011;42:656–661.
96. , , , et al. Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study. Stroke 2004;35:1831–1835.
97. , , , et al. Microbleeds in Alzheimer disease are more related to cerebral amyloid angiopathy than cerebrovascular disease. Dement Geriatr Cogn Disord 2006;22:8–14.
98. , Cerebral microbleeds: detection, mechanisms and clinical challenges. Future Neurol 2011;6:587–611.
99. , , Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages. Neurobiol Aging 2006;27:1786–1796.
100. , , , et al. Absence of cerebral microbleeds predicts reversion of vascular “cognitive impairment no dementia” in stroke. Int J Stroke 2011;6:498–505.
101. , , , et al. Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann Neurol 2010;68:545–548.
102. , , , et al. Cerebral microbleeds are regionally associated with intracerebral hemorrhage. Neurology 2004;62:72–76.
103. , , Cerebral microbleeds on magnetic resonance imaging and anticoagulant-associated intracerebral hemorrhage risk. Front Neurol 2012;3:133.
104. , Cerebral microbleeds and cognition in cerebrovascular disease: an update. J Neurol Sci 2012.
105. , , , et al. Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke 2005;36:1184–1188.
106. Cerebral microbleeds: clinical and pathophysiological significance. J Neuroimaging 2007;17:193–203.
107. , , , , Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol 2001;49:697–705.
108. Cerebral amyloid angiopathy: the vascular pathology and complications. J Neuropathol Exp Neurol 1986;45:79–90.
109. , Ultrastructural features of cerebral amyloid angiopathy. Hum Pathol 1982;13:1127–1132.
110. , Cerebral amyloid angiopathy in the elderly. Ann Neurol 2011;70:871–880.
111. , , , et al. Cerebral microbleeds predict impending intracranial hemorrhage in infective endocarditis. Cerebrovasc Dis 2011;32:483–488.
112. , , , et al. Brain microbleeds as a potential risk factor for antiplatelet-related intracerebral haemorrhage: hospital-based, case-control study. J Neurol Neurosurg Psychiatry 2010;81:679–684.
113. , , , et al. Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study. Arch Neurol 2009;66:714–720.
114. , , , , Asymptomatic microbleeds as a risk factor for aspirin-associated intracerebral hemorrhages. Neurology 2003;60:511–513.
115. , , , Cerebral microbleeds and the risk of intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry 2013;84:277–280.
116. , , , Postthrombolysis intracranial hemorrhage risk of cerebral microbleeds in acute stroke patients: a systematic review and meta-analysis. Int J Stroke 2013;8:348–356.
117. , Brain microbleeds and Alzheimer’s disease: innocent observation or key player? Brain 2011;134:335–344.