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Chapter 37 - Magnetic resonance spectroscopy in psychiatry

from Section 6 - Psychiatric and neurodegenerative diseases

Published online by Cambridge University Press:  05 March 2013

By
John D. Port  and
Basant K. Puri
Edited by
Jonathan H. Gillard ,
Adam D. Waldman  and
Peter B. Barker
Jonathan H. Gillard
Affiliation:
University of Cambridge
Adam D. Waldman
Affiliation:
Imperial College London
Peter B. Barker
Affiliation:
The Johns Hopkins University School of Medicine
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Summary

Introduction

Magnetic resonance spectroscopy (MRS) holds great promise for the diagnosis and management of psychiatric disease. The technique has been available for humans since 1973 but was limited to major medical centers where experimental spectroscopy sequences and dedicated support personnel were available, limiting clinical accessibility to researchers rather than clinicians. The advent of commercial clinical spectroscopy software, which was approved by the US Food and Drug Administration in 1995, made clinical MRS widely available, and the number of psychiatric MRS studies proliferated.

The increasing interest in psychiatric MRS results from the low sensitivity and specificity shown in most structural imaging studies for detecting psychiatric disease (e.g.,[1]). To date, there are few anatomical markers of psychiatric disease that are considered “reliable.” This finding correlates well with the clinical impression that psychiatric diseases are primarily functional, caused by chemical imbalances or microscopic structural differences that are not detectable with current technology. While clinical MR examinations of psychiatric patients are occasionally performed, the clinical indication is usually to rule out any organic causes for the patient’s behavioral anomalies, rather than to make a diagnosis of a particular psychiatric disease.

Type
Chapter
Information
Clinical MR Neuroimaging
Physiological and Functional Techniques
 , pp. 566 - 592
Publisher: Cambridge University Press
Print publication year: 2009

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References

Krystal, JH, D’Souza, DC, Sanacora, G, Goddard, AW, Charney, DS.Current perspectives on the pathophysiology of schizophrenia, depression, and anxiety disorders. Med Clin N Am 2001; 85: 559–577.CrossRefGoogle ScholarPubMed
Yildiz, A, Sachs, GS, Dorer, DJ, Renshaw, PF.31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: a meta-analysis. Psychiatry Res 2001; 106: 181–191.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 3rd edn. 1980. Washington DC: American Psychiatric Association,Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 4th edn text revision. Washington. DC: American Psychiatric Association, 2000.Google Scholar
Auer, DP, Putz, B, Kraft, E, et al. Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry 2000; 47: 305–313.CrossRefGoogle Scholar
Frey, R, Metzler, D, Fischer, P, et al. myo-Inositol in depressive and healthy subjects determined by frontal 1H-magnetic resonance spectroscopy at 1.5 tesla. J Psychiatr Res 1998; 32: 411–420.CrossRefGoogle ScholarPubMed
Renshaw, PF, Guimaraes, AR, Fava, M, et al. Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration. Am J Psychiatry 1992; 149: 1592–1594.Google ScholarPubMed
Cohen, J.Statistical Power Analysis for the Behavioral Sciences. New York: Academic Press, 1977.Google Scholar
Kreis, R, Ernst, T, Ross, BD.Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Reson Med 1993; 30: 424–437.CrossRefGoogle ScholarPubMed
van der Knaap, MS, van der Grond, J, van Rijen, PC, et al. Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain. Radiology 1990; 176: 509–515.CrossRefGoogle Scholar
Ross, B, Bluml, S.Magnetic resonance spectroscopy of the human brain. Anat Rec 2001; 265: 54–84.CrossRefGoogle ScholarPubMed
Fukuzako, H, Hashiguchi, T, Sakamoto, Y, et al. Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects. Psychiatr Clin Neurosci 1997; 51: 261–263.CrossRefGoogle ScholarPubMed
Charles, HC, Lazeyras, F, Krishnan, KR, et al. Proton spectroscopy of human brain: effects of age and sex. Prog Neuropsychopharmacol Biol Psychiatry 1994; 18: 995–1004.CrossRefGoogle ScholarPubMed
Sijens, PE, Heijer Td, T, Origgi, D, et al. Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men. Radiology 2003; 226: 889–896.CrossRefGoogle ScholarPubMed
Ebert, D, Speck, O, Konig, A, et al. 1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum. Psychiatry Res 1997; 74: 173–176.CrossRefGoogle ScholarPubMed
Brodmann, K.Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues, Leipzig: JA Barth, 1909.Google Scholar
Winsberg, ME, Sachs, N, Tate, DL, et al. Decreased dorsolateral prefrontal N-acetylaspartate in bipolar disorder. Biol Psychiatry 2000; 47: 475–481.CrossRefGoogle Scholar
Kinney, DK, Steingard, RJ, Renshaw, PF, Yurgelun-Todd, DA.Perinatal complications and abnormal proton metabolite concentrations in frontal cortex of adolescents seen on magnetic resonance spectroscopy. Neuropsychiatr Neuropsychol Behav Neurol 2000; 13: 8–12.Google ScholarPubMed
Bottomley, PA.The trouble with spectroscopy papers. Radiology 1991; 181: 344–350.CrossRefGoogle ScholarPubMed
Pfefferbaum, A, Adalsteinsson, E, Spielman, D, Sullivan, EV, Lim, KO.In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease. Arch Gen Psychiatry 1999; 56: 185–192.CrossRefGoogle ScholarPubMed
McLean, MA, Woermann, FG, Barker, GJ, Duncan, JS.Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter. Magn Reson Med 2000; 44: 401–411.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Deicken, RF, Eliaz, Y, Feiwell, R, Schuff, N.Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder. Psychiatry Res 2001; 106: 35–45.CrossRefGoogle ScholarPubMed
Schuff, N, Neylan, TC, Lenoci, MA, et al. Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder. Biol Psychiatry 2001; 50: 952–959.CrossRefGoogle ScholarPubMed
Villarreal, G, Petropoulos, H, Hamilton, DA, et al. Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary results. Can J Psychiatry 2002; 47: 666–670.CrossRefGoogle ScholarPubMed
Sharma, R, Venkatasubramanian, PN, Barany, M, Davis, JM.Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients. Schizophr Res 1992; 8: 43–49.CrossRefGoogle ScholarPubMed
Charles, HC, Lazeyras, F, Krishnan, KR, et al. Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry 1994; 18: 1121–1127.CrossRefGoogle ScholarPubMed
Renshaw, PF, Lafer, B, Babb, SM, et al. Basal ganglia choline levels in depression and response to fluoxetine treatment: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry 1997; 41: 837–843.CrossRefGoogle Scholar
Hamakawa, H, Kato, T, Murashita, J, Kato, N.Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders. Eur Arch Psychiatr Clin Neurosci 1998; 248: 53–58.CrossRefGoogle ScholarPubMed
Sanacora, G, Mason, GF, Rothman, DL, et al. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry 1999; 56: 1043–1047.CrossRefGoogle ScholarPubMed
Sonawalla, SB, Renshaw, PF, Moore, CM, et al. Compounds containing cytosolic choline in the basal ganglia: a potential biological marker of true drug response to fluoxetine. Am J Psychiatry 1999; 156: 1638–1640.CrossRefGoogle ScholarPubMed
Ende, G, Braus, DF, Walter, S, Weber-Fahr, W, Henn, FA.The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study. Arch Gen Psychiatry 2000; 57: 937–943.CrossRefGoogle ScholarPubMed
Steingard, RJ, Yurgelun-Todd, DA, Hennen, J, et al. Increased orbitofrontal cortex levels of choline in depressed adolescents as detected by in vivo proton magnetic resonance spectroscopy. Biol Psychiatry 2000; 48: 1053–1061.CrossRefGoogle ScholarPubMed
Murata, T, Kimura, H, Omori, M, et al. MRI white matter hyperintensities, (1)H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early- and late-onset cases. Int J Geriatr Psychiatry 2001; 16: 1129–1135.CrossRefGoogle ScholarPubMed
Kusumakar, V, MacMaster, FP, Gates, L, Sparkes, SJ, Khan, SC.Left medial temporal cytosolic choline in early onset depression. Can J Psychiatry 2001; 46: 959–964.CrossRefGoogle ScholarPubMed
Kato, T, Takahashi, S, Shioiri, T, Inubushi, T.Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. J Affect Disord 1992; 26: 223–230.CrossRefGoogle ScholarPubMed
Moore, CM, Christensen, JD, Lafer, B, Fava, M, Renshaw, PF.Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy study. Am J Psychiatry 1997; 154: 116–118.Google ScholarPubMed
Volz, HP, Rzanny, R, Riehemann, S, et al. 31P Magnetic resonance spectroscopy in the frontal lobe of major depressed patients. Eur Arch Psychiatr Clin Neurosci 1998; 248: 289–295.CrossRefGoogle ScholarPubMed
Renshaw, PF, Parow, AM, Hirashima, F, et al. Multinuclear magnetic resonance spectroscopy studies of brain purines in major depression. Am J Psychiatry 2001; 158: 2048–2055.CrossRefGoogle ScholarPubMed
Riedl, U, Barocka, A, Kolem, H, et al. Duration of lithium treatment and brain lithium concentration in patients with unipolar and schizoaffective disorder: a study with magnetic resonance spectroscopy. Biol Psychiatry 1997; 41: 844–850.CrossRefGoogle ScholarPubMed
Kumar, A, Thomas, A, Lavretsky, H, et al. Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy. Am J Psychiatry 2002; 159: 630–636.CrossRefGoogle ScholarPubMed
Sanacora, G, Gueorguieva, R, Epperson, CN, et al. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depressionArch Gen Psychiatry 2004; 61: 705–713.CrossRefGoogle ScholarPubMed
Coupland, NJ, Ogilvie, CJ, Hegadoren, KM, Decreased prefrontal myo-inositol in major depressive disorder. Biol Psychiatry 2005; 57: 1526–1534.CrossRefGoogle ScholarPubMed
Rosenberg, DR, Macmaster, FP.Mirza, Y, et al. Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study. Biol Psychiatry 2005; 58: 700–704.CrossRefGoogle ScholarPubMed
Sanacora, G, Fenton, LR, Fasula, MK, et al. Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy. Biol Psychiatry 2006; 59: 284–286.CrossRefGoogle ScholarPubMed
Gonul, AS, Kitis, O, Ozan, E, et al. The effect of antidepressant treatment on N-acetyl aspartate levels of medial frontal cortex in drug-free depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 120–125.CrossRefGoogle ScholarPubMed
Luborzewski, A, Schubert, F, Seifert, F, et al. Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression. J Psychiatr Res 2007; 41: 606–615.CrossRefGoogle ScholarPubMed
Hasler, G, van der Veen, JW, Tumonis, T, et al. Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry 2007; 64: 193–200.CrossRefGoogle ScholarPubMed
Gabbay, V, Hess, DA, Liu, S, et al. Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study. Am J Psychiatry 2007; 164: 1881–1889.CrossRefGoogle ScholarPubMed
Iosifescu, DV, Bolo, NR, Nierenberg, AA, et al. Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorder. Biol Psychiatry 2008; 63: 1127–1134.CrossRefGoogle ScholarPubMed
Block, W, Träber, F, von Widdern, O, et al. Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response. Int J Neuropsychopharmacol 2008; 10: 1–8.Google Scholar
Kessler, RC, McGonagle, KA, Zhao, S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National comorbidity survey. Arch Gen Psychiatry 1994; 51: 8–19.CrossRefGoogle ScholarPubMed
Kessler, RC, Rubinow, DR, Holmes, C, Abelson, JM, Zhao, S.The epidemiology of DSM-III-R bipolar I disorder in a general population survey. Psychol Med 1997; 27: 1079–1089.CrossRefGoogle Scholar
Michels, R, Marzuk, PM.Progress in psychiatry (1). New Engl J Med 1993; 329: 552–560.CrossRefGoogle Scholar
Michels, R, Marzuk, PM.Progress in psychiatry (2). New Engl J Med 1993; 329: 628–638.CrossRefGoogle Scholar
Stoll, AL, Renshaw, PF, Sachs, GS, et al. The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry 1992; 32: 944–949.CrossRefGoogle Scholar
Kato, T, Hamakawa, H, Shioiri, T, et al. Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder. J Psychiatr Neurosci 1996; 21: 248–254.Google ScholarPubMed
Ohara, K, Isoda, H, Suzuki, Y, et al. Proton magnetic resonance spectroscopy of the lenticular nuclei in bipolar I affective disorder. Psychiatry Res 1998; 84: 55–60.CrossRefGoogle ScholarPubMed
Hamakawa, H, Kato, T, Shioiri, T, Inubushi, T, Kato, N.Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder. Psychol Med 1999; 29: 639–644.CrossRefGoogle ScholarPubMed
Moore, GJ, Bebchuk, JM, Parrish, JK, et al. Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness. Am J Psychiatry 1999; 156: 1902–1908.Google ScholarPubMed
Castillo, M, Kwock, L, Courvoisie, H, Hooper, SR.Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations. AJNR Am J Neuroradiol 2000; 21: 832–838.Google ScholarPubMed
Moore, GJ, Bebchuk, JM, Hasanat, K, et al. Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2’s neurotrophic effects? Biol Psychiatry 2000; 48: 1–8.CrossRefGoogle ScholarPubMed
Moore, CM, Breeze, JL, Gruber, SA, et al. Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. Bipolar Disord 2000; 2: 207–216.CrossRefGoogle ScholarPubMed
Davanzo, P, Thomas, MA, Yue, K, et al. Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder. Neuropsychopharmacology 2001; 24: 359–369.CrossRefGoogle ScholarPubMed
Kato, T, Shioiri, T, Takahashi, S, Inubushi, T.Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS. J Affect Disord 1991; 22: 185–190.CrossRefGoogle ScholarPubMed
Kato, T, Takahashi, S, Shioiri, T, Inubushi, T.Alterations in brain phosphorus metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. J Affect Disord 1993; 27: 53–59.CrossRefGoogle Scholar
Kato, T, Shioiri, T, Murashita, J, et al. Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder. Psychiatry Res 1994; 55: 41–50.CrossRefGoogle ScholarPubMed
Kato, T, Takahashi, S, Shioiri, T, et al. Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. J Affect Disord 1994; 31: 125–133.CrossRefGoogle ScholarPubMed
Kato, T, Shioiri, T, Murashita, J, et al. Lateralized abnormality of high energy phosphate metabolism in the frontal lobes of patients with bipolar disorder detected by phase-encoded 31P-MRS. Psychol Med 1995; 25: 557–566.CrossRefGoogle ScholarPubMed
Deicken, RF, Weiner, MW, Fein, G.Decreased temporal lobe phosphomonoesters in bipolar disorder. J Affect Disord 1995; 33: 195–199.CrossRefGoogle ScholarPubMed
Deicken, RF, Fein, G, Weiner, MW.Abnormal frontal lobe phosphorous metabolism in bipolar disorder. Am J Psychiatry 1995; 152: 915–918.Google ScholarPubMed
Kato, T, Murashita, J, Kamiya, A, et al. Decreased brain intracellular pH measured by 31P-MRS in bipolar disorder: a confirmation in drug-free patients and correlation with white matter hyperintensity. Eur Arch Psychiatr Clin Neurosci 1998; 248: 301–306.CrossRefGoogle ScholarPubMed
Kato, T, Inubushi, T, Takahashi, S.Relationship of lithium concentrations in the brain measured by lithium-7 magnetic resonance spectroscopy to treatment response in mania. J Clin Psychopharmacol 1994; 14: 330–335.Google Scholar
Kato, T, Fujii, K, Shioiri, T, Inubushi, T, Takahashi, S.Lithium side effects in relation to brain lithium concentration measured by lithium-7 magnetic resonance spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry 1996; 20: 87–97.CrossRefGoogle ScholarPubMed
Sun, Z, Wang, F, Cui, L, et al. Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study. Neuroreport 2003; 14: 1833–1836.CrossRefGoogle ScholarPubMed
Frye, MA, Watzl, J, Banakar, S, et al. Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology 2007; 32: 2490–2499.CrossRefGoogle ScholarPubMed
Olvera, RL, Caetano, SC, Fonseca, M, et al. A 1H magnetic resonance spectroscopy study in adults with obsessive compulsive disorder: relationship between metabolite concentrations and symptom severity. J Neural Transm 2008; 115: 1051–1062.Google Scholar
Colla, M, Schubert, F, Bubner, M, et al. Glutamate as a spectroscopic marker of hippocampal structural plasticity is elevated in long-term euthymic bipolar patients on chronic lithium therapy and correlates inversely with diurnal cortisol. Mol Psychiatry 2008; Epub before print doi: 10.1038/mp.2008.26.CrossRef
Öngür, D, Jensen, JE, Prescot, AP, et al. Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania. Biol Psychiatry 2008; 64: 718–726.CrossRefGoogle ScholarPubMed
Port, JD, Unal, SS, Mrazek, DA, Marcus, SM.Metabolic alterations in medication-free patients with bipolar disorder: a 3 T CSF-corrected magnetic resonance spectroscopic imaging study. Psychiatry Res 2008; 162: 113–121.CrossRefGoogle Scholar
Soares, JC, Boada, F, Spencer, S, et al. Brain lithium concentrations in bipolar disorder patients: preliminary (7)Li magnetic resonance studies at 3 T. Biol Psychiatry 2001; 49: 437–443.CrossRefGoogle ScholarPubMed
Moore, CM, Demopulos, CM, Henry, ME, et al. Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy study. Am J Psychiatry 2002; 159: 1240–1242.CrossRefGoogle ScholarPubMed
Atack, JR, Broughton, HB, Pollack, SJ.Inositol monophosphatase: a putative target for 1Li in the treatment of bipolar disorder. Trend Neurosci 1995; 18: 343–349.CrossRefGoogle Scholar
Belmaker, RH, Bersudsky, Y, Agam, G, Levine, J, Kofman, O.How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory. Annu Rev Med 1996; 47: 47–56.CrossRefGoogle ScholarPubMed
Soares, JC, Mallinger, AG.Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients. Psychopharmacol Bull 1997; 33: 685–691.Google ScholarPubMed
Dager, SR, Marro, KI, Richards, TL, Metzger, GD.Preliminary application of magnetic resonance spectroscopy to investigate lactate-induced panic. Am J Psychiatry 1994; 151: 57–63.Google ScholarPubMed
Dager, SR, Strauss, WL, Marro, KI, et al. Proton magnetic resonance spectroscopy investigation of hyperventilation in subjects with panic disorder and comparison subjects. Am J Psychiatry 1995; 152: 666–672.Google ScholarPubMed
Dager, SR, Richards, T, Strauss, W, Artru, A.Single-voxel 1H-MRS investigation of brain metabolic changes during lactate-induced panic. Psychiatry Res 1997; 76: 89–99.CrossRefGoogle ScholarPubMed
Dager, SR, Friedman, SD, Heide, A, et al. Two-dimensional proton echo-planar spectroscopic imaging of brain metabolic changes during lactate-induced panic. Arch Gen Psychiatry 1999; 56: 70–77.CrossRefGoogle ScholarPubMed
Goddard, AW, Mason, GF, Almai, A, et al. Reductions in occipital cortex GABA levels in panic disorder detected with 1H-magnetic resonance spectroscopy. Arch Gen Psychiatry 2001; 58: 556–561.CrossRefGoogle ScholarPubMed
Layton, ME, Friedman, SD, Dager, SR.Brain metabolic changes during lactate-induced panic: effects of gabapentin treatment. Depress Anxiety 2001; 14: 251–254.CrossRefGoogle ScholarPubMed
Massana, G, Gasto, C, Junque, C, et al. Reduced levels of creatine in the right medial temporal lobe region of panic disorder patients detected with (1)H magnetic resonance spectroscopy. Neuroimage 2002; 16: 836–842.CrossRefGoogle ScholarPubMed
Shioiri, T, Kato, T, Murashita, J, et al. High-energy phosphate metabolism in the frontal lobes of patients with panic disorder detected by phase-encoded 31P-MRS. Biol Psychiatry 1996; 40: 785–793.CrossRefGoogle ScholarPubMed
Ham, BJ, Sung, Y, Kim, N, et al. Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: a proton magnetic resonance spectroscopy (1H-MRS) study. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 403–411.CrossRefGoogle ScholarPubMed
Pitts Jr, FN, McClure, JN, Jr. Lactate metabolism in anxiety neurosis. New Engl J Med 1967; 277: 1329–1336.CrossRefGoogle Scholar
Weissman, MM, Bland, RC, Canino, GJ, Cross National Collaborative Group. The cross national epidemiology of obsessive compulsive disorder. J Clin Psychiatry 1994; 55(Suppl): 5–10.Google Scholar
Koran, LM, Thienemann, ML, Davenport, R.Quality of life for patients with obsessive-compulsive disorder. Am J Psychiatry 1996; 153: 783–788.Google ScholarPubMed
Bartha, R, Stein, MB, Williamson, PC, et al. A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive-compulsive disorder and comparison subjects. Am J Psychiatry 1998; 155: 1584–1591.CrossRefGoogle Scholar
Moore, GJ, MacMaster, FP, Stewart, C, Rosenberg, DR.Case study: caudate glutamatergic changes with paroxetine therapy for pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 1998; 37: 663–667.CrossRefGoogle ScholarPubMed
Ohara, K, Isoda, H, Suzuki, Y, et al. Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder. Psychiatry Res 1999; 92: 83–91.CrossRefGoogle ScholarPubMed
Fitzgerald, KD, Moore, GJ, Paulson, LA, Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder. Biol Psychiatry 2000; 47: 174–182.CrossRefGoogle ScholarPubMed
Rosenberg, DR, MacMaster, FP, Keshavan, MS, et al. Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry 2000; 39: 1096–1103.CrossRefGoogle ScholarPubMed
Bolton, J, Moore, GJ, MacMillan, S, Stewart, CM, Rosenberg, DR.Case study: caudate glutamatergic changes with paroxetine persist after medication discontinuation in pediatric OCD. J Am Acad Child Adolesc Psychiatry 2001; 40: 903–906.CrossRefGoogle ScholarPubMed
Rosenberg, DR, Amponsah, A, Sullivan, A, MacMillan, S, Moore, GJ.Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging. J Child Neurol 2001; 16: 636–641.CrossRefGoogle Scholar
Strauss, WL, Layton, ME, Hayes, CE, Dager, SR.19F Magnetic resonance spectroscopy investigation in vivo of acute and steady-state brain fluvoxamine levels in obsessive-compulsive disorder. Am J Psychiatry 1997; 154: 516–522.Google ScholarPubMed
Whiteside, SP, Port, JD, Deacon, BJ, Abramowitz, JS.A magnetic resonance spectroscopy investigation of obsessive-compulsive disorder and anxiety. Psychiatry Res 2006; 146: 137–147.CrossRefGoogle ScholarPubMed
Jang, JH, Kwon, JS, Jang, DP, et al. A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder. Am J Psychiatry 2006; 163: 1202–1207.CrossRefGoogle ScholarPubMed
Yücel, M, Wood, SJ, Wellard, RM, et al. Anterior cingulate glutamate–glutamine levels predict symptom severity in women with obsessive-compulsive disorder. Aust N Z J Psychiatry 2008; 42: 467–477.CrossRefGoogle Scholar
Starck, G, Ljungberg, M, Nilsson, M, et al. A 1H magnetic resonance spectroscopy study in adults with obsessive compulsive disorder: relationship between metabolite concentrations and symptom severity. J Neur Transmis 2008; 115: 1051–1562CrossRefGoogle ScholarPubMed
Smith, EA, Russell, A, Lorch, E, et al. Increased medial thalamic choline found in pediatric patients with obsessive–compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study. Biol Psychiatry 2003; 54: 1399–1405.CrossRefGoogle ScholarPubMed
Russell, A, Cortese, B, Lorch, E, et al. Localized functional neurochemical marker abnormalities in dorsolateral prefrontal cortex in pediatric obsessive–compulsive disorder. J Child Adolesc Psychopharmacology 2003; 13(Suppl 1): S31–S38.CrossRefGoogle ScholarPubMed
Rosenberg, DR, Mirza, Y, Russell, A, et al. Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls, J Am Acad Child Adolesc Psychiatry 2004; 43: 1146–1153.CrossRefGoogle ScholarPubMed
Freeman, TW, Cardwell, D, Karson, CN, Komoroski, RA.In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of subjects with combat-related posttraumatic stress disorder. Magn Reson Med 1998; 40: 66–71.CrossRefGoogle ScholarPubMed
De Bellis, MD, Keshavan, MS, Spencer, S, Hall, J.N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD. Am J Psychiatry 2000; 157: 1175–1177.CrossRefGoogle ScholarPubMed
De Bellis, MD, Keshavan, MS, Harenski, KA.Anterior cingulate N-acetylaspartate/creatine ratios during clonidine treatment in a maltreated child with posttraumatic stress disorder. J Child Adolesc Psychopharmacol 2001; 11: 311–316.CrossRefGoogle Scholar
Brown, S, Freeman, T, Kimbrell, T, Cardwell, D, Komoroski, R.In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of former prisoners of war with and without posttraumatic stress disorder. J Neuropsychiatry Clin Neurosci 2003; 15: 367–370.CrossRefGoogle ScholarPubMed
Ham, BJ, Chey, J, Yoon, SJ, et al. Decreased N-acetyl-aspartate levels in anterior cingulate and hippocampus in subjects with post-traumatic stress disorder: a proton magnetic resonance spectroscopy study. Eur J Neurosci 2007; 25: 324–329.CrossRefGoogle ScholarPubMed
Schuff, N, Neylan, TC, Fox-Bosetti, S, et al. Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder. Psychiatry Res 2008; 162: 147–157.CrossRefGoogle ScholarPubMed
Hanstock, CC, Rothman, DL, Shulman, RG, et al. Measurement of ethanol in the human brain using NMR spectroscopy. J Stud Alcohol 1990; 51: 104–107.CrossRefGoogle ScholarPubMed
Mendelson, JH, Woods, BT, Chiu, TM, et al. In vivo proton magnetic resonance spectroscopy of alcohol in human brain. Alcohol 1990; 7: 443–447.CrossRefGoogle ScholarPubMed
Spielman, DM, Glover, GH, Macovski, A, Pfefferbaum, A.Magnetic resonance spectroscopic imaging of ethanol in the human brain: a feasibility study. Alcohol Clin Exp Res 1993; 17: 1072–1077.CrossRefGoogle ScholarPubMed
Chiu, TM, Mendelson, JH, Woods, BT, In vivo proton magnetic resonance spectroscopy detection of human alcohol tolerance. Magn Reson Med 1994; 32: 511–516.CrossRefGoogle ScholarPubMed
Martin, PR, Gibbs, SJ, Nimmerrichter, AA, et al. Brain proton magnetic resonance spectroscopy studies in recently abstinent alcoholics. Alcohol Clin Exp Res 1995; 19: 1078–1082.CrossRefGoogle ScholarPubMed
Jagannathan, NR, Desai, NG, Raghunathan, P.Brain metabolite changes in alcoholism: an in vivo proton magnetic resonance spectroscopy (MRS) study. Magn Reson Imaging 1996; 14: 553–557.CrossRefGoogle Scholar
Behar, KL, Rothman, DL, Petersen, KF, et al. Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients. Am J Psychiatry 1999; 156: 952–954.CrossRefGoogle ScholarPubMed
Seitz, D, Widmann, U, Seeger, U, et al. Localized proton magnetic resonance spectroscopy of the cerebellum in detoxifying alcoholics. Alcohol Clin Exp Res 1999; 23: 158–163.CrossRefGoogle ScholarPubMed
Schweinsburg, BC, Taylor, MJ, Videen, JS, et al. Elevated myo-inositol in gray matter of recently detoxified but not long-term abstinent alcoholics: a preliminary MR spectroscopy study. Alcohol Clin Exp Res 2000; 24: 699–705.CrossRefGoogle Scholar
Schweinsburg, BC, Taylor, MJ, Alhassoon, OM, et al. Chemical pathology in brain white matter of recently detoxified alcoholics: a 1H magnetic resonance spectroscopy investigation of alcohol-associated frontal lobe injury. Alcohol Clin Exp Res 2001; 25: 924–934.CrossRefGoogle ScholarPubMed
O’Neill, J, Cardenas, VA, Meyerhoff, DJ.Effects of abstinence on the brain: quantitative magnetic resonance imaging and magnetic resonance spectroscopic imaging in chronic alcohol abuse. Alcohol Clin Exp Res 2001; 25: 1673–1682.CrossRefGoogle ScholarPubMed
Bendszus, M, Weijers, HG, Wiesbeck, G, et al. Sequential MR imaging and proton MR spectroscopy in patients who underwent recent detoxification for chronic alcoholism: correlation with clinical and neuropsychological data. AJNR Am J Neuroradiol 2001; 22: 1926–1932.Google ScholarPubMed
Parks, MH, Dawant, BM, Riddle, WR, et al. Longitudinal brain metabolic characterization of chronic alcoholics with proton magnetic resonance spectroscopy. Alcohol Clin Exp Res 2002; 26: 1368–1380.CrossRefGoogle ScholarPubMed
Schweinsburg, BC, Alhassoon, OM, Taylor, MJ, et al. Effects of alcoholism and gender on brain metabolism. Am J Psychiatry 2003; 160: 1180–1183.CrossRefGoogle ScholarPubMed
Meyerhoff, DJ, MacKay, S, Sappey-Marinier, D, et al. Effects of chronic alcohol abuse and HIV infection on brain phosphorus metabolites. Alcohol Clin Exp Res 1995; 19: 685–692.CrossRefGoogle ScholarPubMed
Estilaei, MR, Matson, GB, Payne, GS, et al. Effects of chronic alcohol consumption on the broad phospholipid signal in human brain: an in vivo 31P MRS study. Alcohol Clin Exp Res 2001; 25: 89–97.CrossRefGoogle ScholarPubMed
Estilaei, MR, Matson, GB, Payne, GS, et al. Effects of abstinence from alcohol on the broad phospholipid signal in human brain: an in vivo 31P magnetic resonance spectroscopy study. Alcohol Clin Exp Res 2001; 25: 1213–1220.CrossRefGoogle Scholar
Bartsch, AJ, Homola, G, Biller, A, et al. Manifestations of early brain recovery associated with abstinence from alcoholism. Brain 2007; 130: 36–47.CrossRefGoogle ScholarPubMed
Bloomer, CW, Langleben, DD, Meyerhoff, DJ.Magnetic resonance detects brainstem changes in chronic, active heavy drinkers. Psychiatry Res 2004; 132: 209–218.CrossRefGoogle ScholarPubMed
Durazzo, TC, Gazdzinski, S, Banys, P, Meyerhoff, DJ.Cigarette smoking exacerbates chronic alcohol-induced brain damage. A preliminary metabolite imaging study. Alcohol Clin Exp Res 2004; 28:1849–1860.CrossRefGoogle ScholarPubMed
Meyerhoff, DJ, Blumenfeld, R, Truran, D, et al. Effects of heavy drinking, binge drinking, and family history of alcoholism on regional brain metabolites. Alcohol Clin Exp Res 2004; 28:650–661.CrossRefGoogle ScholarPubMed
Viola, A, Nicoli, F, Denis, B, et al. High cerebral scyllo-inositol: a new marker of brain metabolism disturbances induced by chronic alcoholism. MAGMA 2004; 17: 47–61.CrossRefGoogle ScholarPubMed
Ende, G, Welzel, H, Walter, S, et al. Monitoring the effects of chronic alcohol consumption and abstinence on brain metabolism: a longitudinal proton magnetic resonance spectroscopy study. Biol Psychiatry 2005; 58: 974–980.CrossRefGoogle ScholarPubMed
Mason, GF, Petrakis, IL, de Graaf, RA, et al. Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking. Biol Psychiatry 2006; 59:85–93.CrossRefGoogle ScholarPubMed
Kasai, K, Iwanami, A, Yamasue, H, et al. Neuroanatomy and neurophysiology in schizophrenia. Neurosci Res 2002; 43: 93–110.CrossRefGoogle Scholar
Lyoo, IK, Renshaw, PF.Magnetic resonance spectroscopy: current and future applications in psychiatric research. Biol Psychiatry 2002; 51: 195–207.CrossRefGoogle ScholarPubMed
Soares, JC, Innis, RB.Neurochemical brain imaging investigations of schizophrenia. Biol Psychiatry 1999; 46: 600–615.CrossRefGoogle ScholarPubMed
Curtis, VA, van Os, J, Murray, RM.The Kraepelinian dichotomy: evidence from developmental and neuroimaging studies. J Neuropsychiatr Clin Neurosci 2000; 12: 398–405.CrossRefGoogle ScholarPubMed
Keshavan, MS, Stanley, JA, Pettegrew, JW.Magnetic resonance spectroscopy in schizophrenia: methodological issues and findings: Part II. Biol Psychiatry 2000; 48: 369–380.CrossRefGoogle ScholarPubMed
Laruelle, M.The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies. Brain Res Rev 2000; 31: 371–384.CrossRefGoogle ScholarPubMed
Stanley, JA, Pettegrew, JW, Keshavan, MS.Magnetic resonance spectroscopy in schizophrenia: methodological issues and findings: Part I. Biol Psychiatry 2000; 48: 357–368.CrossRefGoogle ScholarPubMed
Vance, AL, Velakoulis, D, Maruff, P, et al. Magnetic resonance spectroscopy and schizophrenia: what have we learnt? Aust NZ J Psychiatry 2000; 34: 14–25.CrossRefGoogle ScholarPubMed
Stanley, JA.In vivo magnetic resonance spectroscopy and its application to neuropsychiatric disorders [comment]. Can J Psychiatry 2002; 47: 315–326.CrossRefGoogle Scholar
Abbott, C, Bustillo, J.What have we learned from proton magnetic resonance spectroscopy about schizophrenia? A critical update. Curr Opin Psychiatry 2006; 19: 135–139.CrossRefGoogle ScholarPubMed
Gur, RE, Keshavan, MS, Lawrie, SM.Deconstructing psychosis with human brain imaging. Schizophr Bull 2007; 33: 921–931.CrossRefGoogle ScholarPubMed
Stanley, JA, Williamson, PC, Drost, DJ, et al. An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy. Arch Gen Psychiatry 1995; 52: 399–406.CrossRefGoogle Scholar
Stanley, JA, Williamson, PC, Drost, DJ, et al. Membrane phospholipid metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study. Schizophr Res 1994; 13: 209–215.CrossRefGoogle Scholar
Puri, BK, Counsell, SJ, Hamilton, G.Brain cell membrane motion-restricted phospholipids: A cerebral 31-phosphorus magnetic resonance spectroscopy study of patients with schizophrenia. Prostaglandins Leukot Essent Fatty Acids 2008; 79: 233–235.CrossRefGoogle ScholarPubMed
Feinberg, I.Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J Psychiatr Res 1982; 17: 319–334.CrossRefGoogle ScholarPubMed
Feinberg, I.Cortical pruning and the development of schizophrenia. Schizophr Bull 1990; 16: 567–570.CrossRefGoogle ScholarPubMed
Pettegrew, JW, Keshavan, MS, Minshew, NJ.31P nuclear magnetic resonance spectroscopy: neurodevelopment and schizophrenia. Schizophr Bull 1993; 19: 35–53.CrossRefGoogle Scholar
Puri, BK, Counsell, SJ, Hamilton, G, et al. Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a 31P magnetic resonance spectroscopy study. Prostaglandins Leukot Essent Fatty Acids 2004; 70: 409–411.CrossRefGoogle ScholarPubMed
Treasaden, IH, Puri, BK.Cerebral spectroscopic and oxidative stress studies in patients with schizophrenia who have dangerously violently offended. BMC Psychiatry 2008; 8(Suppl 1): S7.CrossRefGoogle ScholarPubMed
Puri, BK, Richardson, AJ, Counsell, SJ, et al. Negative correlation between cerebral inorganic phosphate and the volumetric niacin response in male patients with schizophrenia who have seriously and dangerously violently offended: a (31)P magnetic resonance spectroscopy study. Prostaglandins Leukot Essent Fatty Acids 2007; 77: 97–99.CrossRefGoogle ScholarPubMed
Puri, BK, Counsell, SJ, Hamilton, G, Bustos, MG, Treasaden, IH.Brain cell membrane motion-restricted phospholipids in patients with schizophrenia who have seriously and dangerously violently offended. 2008; Prog Neuropsychopharmacol Biol Psychiatry 32: 751–754.CrossRefGoogle ScholarPubMed
Puri, BK, Counsell, SJ, Zaman, R, et al. Relative increase in choline in the occipital cortex in chronic fatigue syndrome. Acta Psychiatr Scand 2002; 106: 224–226.CrossRefGoogle ScholarPubMed
Chaudhuri, A, Condon, BR, Gow, JW, Brennan, D, Hadley, DM.Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome. Neuroreport 2003; 14: 225–228.CrossRefGoogle ScholarPubMed
Tomoda, A, Miike, T, Yamada, E, et al. Chronic fatigue syndrome in childhood. Brain Dev 2000; 22: 60–64.CrossRefGoogle ScholarPubMed
Puri, BK.Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). J Clin Pathol 2007; 60: 122–124.CrossRefGoogle Scholar
Sanacora, G, Rothman, DL, Krystal, JH.Applications of magnetic resonance spectroscopy to psychiatry. Neuroscientist 1999; 5: 192–196.CrossRefGoogle Scholar
Sanacora, G, Mason, GF, Krystal, JH.Impairment of GABAergic transmission in depression: new insights from neuroimaging studies. Crit Rev Neurobiol 2000; 14: 23–45.CrossRefGoogle ScholarPubMed
Soares, JC, Boada, F, Keshavan, MS.Brain lithium measurements with (7)Li magnetic resonance spectroscopy (MRS): a literature review. Eur Neuropsychopharmacol 2000; 10: 151–158.CrossRefGoogle ScholarPubMed

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