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Chapter 17 - Genetics of Mood Disorders

Published online by Cambridge University Press:  16 May 2024

By
Camila Nayane de Carvalho Lima ,
Christopher Busby  and
Gabriel Rodrigo Fries
Edited by
Allan Young ,
Marsal Sanches ,
Jair C. Soares  and
Mario Juruena
Allan Young
Affiliation:
Institute of Psychiatry, King's College London
Marsal Sanches
Affiliation:
Baylor College of Medicine, Texas
Jair C. Soares
Affiliation:
McGovern Medical School, The University of Texas
Mario Juruena
Affiliation:
King's College London
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Summary

Mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD), are known to have a significant genetic component based on familial and twin studies. Tremendous efforts from the scientific community and technical advancements have led to the discovery of multiple genes associated with the heritability of these disorders over the last years. Nonetheless, our knowledge of the exact genetic basis of BD and MDD is still fairly limited. Recent genome-wide association studies with massive sample sizes have started to characterize the polygenicity of these disorders, although future studies have yet to explore how genetic variants may interact with the environment to modulate one’s risk of disease. As our understanding of the genetics of mood disorders increases (with increasing sample sizes, a more significant shift from candidate gene studies to microarray and sequencing strategies, and integration of findings with environmental measures), many clinical opportunities may arise. This may include the future use of polygenic risk scores for risk assessment, predicting response to medications based on genotype, among others.

Keywords

mood disordersbipolar disordermajor depressive disordergeneticsGWASepigenetics
Type
Chapter
Information
Clinical Textbook of Mood Disorders , pp. 172 - 177
Publisher: Cambridge University Press
Print publication year: 2024

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