Persistent post-concussive psychiatric problems are very common. Contrary to a tragic twentieth-century error of empirical observation, more than 40 percent of survivors of typical, medically attended concussive brain injuries (CBIs) will express symptoms that may be, to different and unmeasurable degrees, biologically attributable to the concussion. Most of those symptoms will be psychiatric, and psychiatric symptoms seem to be more disabling, on average, than cognitive symptoms. It is no easy task, however, to research the chain of causality from a visitation by an abrupt external force to persistent neuropsychiatric distress. The first step -- abandoning Cartesian duality and acknowledging that all so-called “behavior” is mediated by organic change -- is just a springboard toward an earnest inquiry. Current knowledge is grossly insufficient for tracing the biodynamics of the interplay between: (a) innate and acquired nervous system function; (b) an external rattling blow; and (c) subsequent alterations in subjective experiences, objective brain operations, and overt actions. This chapter merely attempts to discuss the kinds of thought and research that might accelerate our understanding of symptoms and effective treatments.