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6 - Neurotransmitters, Drugs and Receptors

Published online by Cambridge University Press:  17 May 2025

Anne Buckingham Young
Affiliation:
Massachusetts General Hospital
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Summary

Abstract: Anne and Jack moved with Nancy Serrell into a larger apartment. Anne researched methods of measuring GABA and glycine receptors. She hypothesized that strychnine worked because it was bound to the glycine neurotransmitter receptor. If Anne was right, she would have discovered something new about the lock (receptor) for the key (glycine). Eventually, her experiments demonstrated that [3H]-strychnine would, in fact, bind to rat spinal cord membranes and could be blocked by glycine. Anne felt exhilarated by the experiments she conducted. Her success wasn’t met without competition with Candace Pert, who also succeeded with her research on the opiate receptor. Candace got attention because of how important the opiate receptor was as it dealt with pain, a common issue; Anne’s research on glycine and GABA did not impact the average healthy person. Jack was accepted for a neurology residency at UCSF, and Anne for medical internship at Mount Zion Hospital. A third of Anne’s thesis had to be rewritten after it was stolen from her briefcase when she was mugged. Young defended her thesis on the same day as Pert. They succeeded, but the committee asked Anne to take another year. She told Sol what happened. The next day, as promised, the head of the department changed his mind; she could graduate as expected.

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Chapter
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Disorderly Movements
A Neurologist's Adventures in the Lab and Life
, pp. 94 - 105
Publisher: Cambridge University Press
Print publication year: 2025

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