Fed-Batch Cultures: Principles and Applications of Semi-Batch Bioreactors

Henry C. Lim; Hwa Sung Shin

doi:10.1017/CBO9781139018777

Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.

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Contents

Frontmatter
pp i-viii
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Contents
pp ix-xiv
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Preface
pp xv-xvi
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Acknowledgments
pp xvii-xviii
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1 - Introduction to Fed-Batch Cultures
pp 1-18
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2 - Idealized Reactors and Fed-Batch Reactors
pp 19-32
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3 - Maximization of Reaction Rates and Fed-Batch Operation
pp 33-51
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4 - Phenomena That Favor Fed-Batch Operations
pp 52-61
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5 - Classification and Characteristics of Fed-Batch Cultures
pp 62-84
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6 - Models Based on Mass Balance Equations
pp 85-120
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7 - Non–Equation-Based Models
pp 121-134
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8 - Specific Rate Determination
pp 135-157
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9 - Optimization by Pontryagin's Maximum Principle
pp 158-185
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10 - Computational Techniques
pp 186-206
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11 - Optimization of Single and Multiple Reactions
pp 207-226
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12 - Optimization for Cell Mass Production
pp 227-297
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13 - Optimization for Metabolite Production
pp 298-392
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14 - Simple Adaptive Optimization
pp 393-406
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15 - Measurements, Estimation, and Control
pp 407-436
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16 - Feasibility Assessment and Implementable Feed Rates
pp 437-452
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Index
pp 453-457
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Fed-Batch Cultures

Principles and Applications of Semi-Batch Bioreactors

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Contents

Frontmatter
pp i-viii

Contents
pp ix-xiv

Preface
pp xv-xvi

Acknowledgments
pp xvii-xviii

1 - Introduction to Fed-Batch Cultures
pp 1-18

2 - Idealized Reactors and Fed-Batch Reactors
pp 19-32

3 - Maximization of Reaction Rates and Fed-Batch Operation
pp 33-51

4 - Phenomena That Favor Fed-Batch Operations
pp 52-61

5 - Classification and Characteristics of Fed-Batch Cultures
pp 62-84

6 - Models Based on Mass Balance Equations
pp 85-120

7 - Non–Equation-Based Models
pp 121-134

8 - Specific Rate Determination
pp 135-157

9 - Optimization by Pontryagin's Maximum Principle
pp 158-185

10 - Computational Techniques
pp 186-206

11 - Optimization of Single and Multiple Reactions
pp 207-226

12 - Optimization for Cell Mass Production
pp 227-297

13 - Optimization for Metabolite Production
pp 298-392

14 - Simple Adaptive Optimization
pp 393-406

15 - Measurements, Estimation, and Control
pp 407-436

16 - Feasibility Assessment and Implementable Feed Rates
pp 437-452

Index
pp 453-457

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Fed-Batch Cultures

Principles and Applications of Semi-Batch Bioreactors

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