Survival of Primordial Follicles

doi:10.1017/9781108784368.033

Chapter 32 - Survival of Primordial Follicles

Tips and Tricks

from Section 8 - In Vitro Follicle Culture

Published online by Cambridge University Press: 27 March 2021

Christiani A Amorim and

Carolina M Lucci

Edited by

Jacques Donnez and

S. Samuel Kim

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Jacques Donnez: Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim: Affiliation:
University of Kansas School of Medicine

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Summary

According to the European Society of Human Reproduction and Embryology (ESHRE) Working Group on Oocyte Cryopreservation [], between 2010 and 2014, cancer patients in Europe underwent similar numbers of ovarian tissue cryopreservation procedures (~4,400) and oocyte cryopreservation procedures (~3,800). This milestone in the field of ovarian tissue cryopreservation is responsible for a new surge of interest in primordial follicles and their requirements for survival and development, as they represent more than 90% of the follicle population to be cryopreserved. When patients cannot have their frozen-thawed ovarian tissue reimplanted due to the risk of transmission of malignant cells, these follicles can be isolated and grafted inside a bioengineered ovary (see Chapter 36) or grown in vitro (see Chapter 31). We will focus on the latter strategy, more specifically on the main elements that primordial follicles need to survive in vitro.

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Type: Chapter
Information: Fertility Preservation
Principles and Practice
, pp. 364 - 380

DOI: https://doi.org/10.1017/9781108784368.033 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2021

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References

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