Book contents
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Chapter 1 The Rationale for Fetal Therapy
- Chapter 2 A Fetal Origin of Adult Disease
- Chapter 3 Human Embryology: Molecular Mechanisms of Embryonic Disease
- Chapter 4 Human Genetics and Fetal Disease: Assessment of the Fetal Genome
- Chapter 5 Interventions in Pregnancy to Reduce Risk of Stillbirth
- Chapter 6 Fetal Therapy Choices: Uncertain and Emotional Decisions and the Doctor’s Role in Parental Decision-Making
- Chapter 7 The Ethics of Consent for Fetal Therapy
- Chapter 8 Open Fetal Surgery: Is There Still a Role?
- Chapter 9 The Artificial Womb
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Section III: The Future
- Index
- References
Chapter 5 - Interventions in Pregnancy to Reduce Risk of Stillbirth
from Section 1: - General Principles
Published online by Cambridge University Press: 21 October 2019
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Chapter 1 The Rationale for Fetal Therapy
- Chapter 2 A Fetal Origin of Adult Disease
- Chapter 3 Human Embryology: Molecular Mechanisms of Embryonic Disease
- Chapter 4 Human Genetics and Fetal Disease: Assessment of the Fetal Genome
- Chapter 5 Interventions in Pregnancy to Reduce Risk of Stillbirth
- Chapter 6 Fetal Therapy Choices: Uncertain and Emotional Decisions and the Doctor’s Role in Parental Decision-Making
- Chapter 7 The Ethics of Consent for Fetal Therapy
- Chapter 8 Open Fetal Surgery: Is There Still a Role?
- Chapter 9 The Artificial Womb
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Section III: The Future
- Index
- References
Summary
Stillbirth remains a global health challenge, with more than 2.6 million stillbirths per year [1]. Although only 2% of the global burden of stillbirths is in high-income countries (HICs), with virtually no improvement in rates for over two decades, action in HICs is urgently needed [2]. There is a six-fold difference between the highest and lowest rates (Ukraine 8.8 stillbirths per 1,000 births after 28 weeks vs. Iceland 1.3 stillbirths per 1,000 births). As well as variation between countries it is well established that there is variation within countries, with women from indigenous or minority ethnic groups, migrant populations or socioeconomically deprived groups as well as women at extremes of maternal age being at increased risk of stillbirth [2]. The disparity between and within countries suggests that more could be done in HICs to reduce stillbirth rates: this includes reducing the frequency of substandard care recurrently described in Confidential Enquiries into Stillbirth and implementing strategies to mitigate the increased risk of stillbirth in specific groups of women [3, 4].
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- Information
- Fetal TherapyScientific Basis and Critical Appraisal of Clinical Benefits, pp. 48 - 60Publisher: Cambridge University PressPrint publication year: 2020