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Chapter 51 - Tissue Engineering and the Fetus

from Fetal Stem Cell Transplantation

Published online by Cambridge University Press:  21 October 2019

By
Joseph Davidson  and
Paolo De Coppi
Edited by
Mark D. Kilby ,
Anthony Johnson  and
Dick Oepkes
Mark D. Kilby
Affiliation:
University of Birmingham
Anthony Johnson
Affiliation:
University of Texas Medical School at Houston
Dick Oepkes
Affiliation:
Leids Universitair Medisch Centrum
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Summary

As the fetal domain becomes increasingly accessible for both diagnosis and therapy, so too has the field of regenerative medicine begun to expand into areas relevant to the fetus. With regards to congenital anomalies in the fetus and newborn, a paucity of tissue often precludes anatomical restorative surgery, and either artificial material or a non-anatomical conduit will be used to surgically repair the defect. Hence, a possibility exists for the field of tissue engineering to emerge as a therapeutic avenue for several congenital anomalies.

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Type
Chapter
Information
Fetal Therapy
Scientific Basis and Critical Appraisal of Clinical Benefits
 , pp. 532 - 539
Publisher: Cambridge University Press
Print publication year: 2020

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References

Amit, M, Shariki, C, Margulets, V, Itskovitz-Eldor, J. Feeder layer and serum-free culture of human embryonic stem cells. Biol Reprod. 2004; 70: 837–45.Google Scholar
Fong, H, Hohenstein, KA, Donovan, PJ. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells. 2008; 26: 1931–8.Google Scholar
Klimanskaya, I, Chung, Y, Becker, S, et al. Human embryonic stem cell lines derived from single blastomeres. Nature. 2006; 444: 481–5.Google Scholar
Chung, Y, Klimanskaya, I, Becker, S, Marh, J, Lu, SJ, Johnson, J, et al. Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres. Nature. 2006; 439: 216–19.Google Scholar
Deb, KD, Sarda, K. Human embryonic stem cells: preclinical perspectives. J Transl Med. 2008; 6: 7.Google Scholar
Briggs, R, King, TJ. Transplantation of living nuclei from blastula cells into enucleated frogs’ eggs. Proc Natl Acad Sci USA. 1952; 38: 455–63.Google Scholar
Campbell, KH, McWhir, J, Ritchie, WA, Wilmut, I. Sheep cloned by nuclear transfer from a cultured cell line. Nature. 1996; 380: 64–6.CrossRefGoogle ScholarPubMed
Takahashi, K, Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126: 663–76.CrossRefGoogle ScholarPubMed
Slamecka, J, Salimova, L, McClellan, S, van Kelle, M, Kehl, D, Laurini, J, et al. Non-integrating episomal plasmid-based reprogramming of human amniotic fluid stem cells into induced pluripotent stem cells in chemically defined conditions. Cell Cycle. 2016; 15: 234–49.CrossRefGoogle ScholarPubMed
Velasquez-Mao, AJ, Tsao, CJM, Monroe, MN, Legras, X, Bissig-Choisat, B, Bissig, K-D, et al. Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells. PLoS One. 2017; 12: e0177824.Google Scholar
Chang, C-Y, Ting, H-C, Su, H-L, Jeng, J-R. Combining induced pluripotent stem cells and genome editing technologies for clinical applications. Cell Transplant. 2018; 27: 379–92.CrossRefGoogle ScholarPubMed
De Coppi, P, Pozzobon, M, Piccoli, M, Gazzola, M, Boldrin, L, Slanzi, E, et al. Isolation of mesenchymal stem cells from human vermiform appendix. J Surg Res. 2006; 135: 85–91.Google Scholar
Loukogeorgakis, SP, De Coppi, P. Stem cells from amniotic fluid – potential for regenerative medicine. Best Pract Res Clin Obstet Gynaecol. 2016; 31: 45–57.Google Scholar
De Coppi, P. Tissue engineering and stem cell research. In Puri, P, ed., Newborn Surgery, 4th edn. Boca Raton: CRC Press, 2017, pp. 301–14.Google Scholar
Caves, JM, Kumar, VA, Martinez, AW, Kim, J, Ripberger, CM, Haller, CA, et al. The use of microfiber composites of elastin-like protein matrix reinforced with synthetic collagen in the design of vascular grafts. Biomaterials. 2010; 31: 7175–82.Google Scholar
Gasior, AC, St. Peter, SD. A review of patch options in the repair of congenital diaphragm defects. Pediatr Surg Int. 2012; 28: 327–33.Google Scholar
Mayer, S, Decaluwe, H, Ruol, M, Manodoro, S, Kramer, M, Till, H, et al. Diaphragm repair with a novel cross-linked collagen biomaterial in a growing rabbit model. PLoS One. 2015; 10: e0132021.Google Scholar
Huang, AH, Niklason, LE. Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor. J Vis Exp. 2011; 52: 2646.Google Scholar
Lu, H, Feng, Z, Gu, Z, Liu, C. Growth of outgrowth endothelial cells on aligned PLLA nanofibrous scaffolds. J Mater Sci Mater Med. 2009; 20: 1937–44.Google Scholar
Tillman, BW, Yazdani, SK, Lee, SJ, Geary, RL, Atala, A, Yoo, JJ. The in vivo stability of electrospun polycaprolactone-collagen scaffolds in vascular reconstruction. Biomaterials. 2009; 30: 583–8.Google Scholar
Mathews, A, Colombus, S, Krishnan, VK, Krishnan, LK. Vascular tissue construction on poly(epsilon-caprolactone) scaffolds by dynamic endothelial cell seeding: effect of pore size. J Tissue Eng Regen Med. 2012; 6: 451–61.CrossRefGoogle ScholarPubMed
Zhao, J, Qiu, H, Chen, D, Zhang, W, Zhang, D, Li, M. Development of nanofibrous scaffolds for vascular tissue engineering. Int J Biol Macromol. 2013; 56: 106–13.Google Scholar
Huang, Y-C, Kuo, Y, Huang, Y, Chen, C, Ho, D, Shi, C-S. The effects of adipose-derived stem cells in a rat model of tobacco-associated erectile dysfunction. PLoS One. 2016; 11: e0156725.CrossRefGoogle Scholar
Satake, R, Komura, M, Komura, H, Kodaka, T, Terawaki, K, Ikebukuro, K, et al. Patch tracheoplasty in body tissue engineering using collagenous connective tissue membranes (biosheets). J Pediatr Surg. 2016; 51: 244–8.Google Scholar
Suzuki, K, Komura, M, Terawaki, K, Kodaka, T, Gohara, T, Komura, H, et al. Engineering and repair of diaphragm using biosheet (a collagenous connective tissue membrane) in rabbits. J Pediatr Surg. 2018; 53: 330–4.Google Scholar
Mitchell, IC, Garcia, NM, Barber, R, Ahmad, N, Hicks, BA, Fischer, AC. Permacol: a potential biologic patch alternative in congenital diaphragmatic hernia repair. J Pediatr Surg. 2008; 43: 2161–4.CrossRefGoogle ScholarPubMed
Balayssac, D, Poinas, AC, Pereira, B, Pezet, D. Use of permacol in parietal and general surgery: a bibliographic review. Surg Innov. 2013; 20: 176–82.Google Scholar
Cheng, AW, Abbas, MA, Tejirian, T. Outcome of abdominal wall hernia repair with biologic mesh: PermacolTM versus StratticeTM. Am Surg. 2014; 80: 999–1002.Google Scholar
Gilpin, A, Yang, Y. Decellularization strategies for regenerative medicine: from processing techniques to applications. Biomed Res Int. 2017; 2017: 9831534.CrossRefGoogle ScholarPubMed
Wainwright, DJ. Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns. Burns. 1995; 21: 243–8.Google Scholar
Elliott, MJ, De Coppi, P, Speggiorin, S, Roebuck, D, Butler, CR, Samuel, E, et al. Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study. Lancet. 2012; 380: 994–1000.Google Scholar
Flake, AW, Roncarolo, M-G, Puck, JM, Almeida-Porada, G, Evans, MI, Johnson, MP, et al. Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow. N Engl J Med. 1996; 335: 1806–10.Google Scholar
Adzick, NS, Thom, EA, Spong, CY, Brock, JW 3rd, Burrows, PK, Johnson, MP, et al. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med. 2011; 364: 993–1004.Google Scholar
Götherström, C, Westgren, M, Shaw, SWS, Åström, E, Biswas, A, Byers, PH, et al. Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience. Stem Cells Transl Med. 2014; 3: 255–64.Google Scholar
Deprest, J, Brady, P, Nicolaides, K, Benachi, A, Berg, C, Vermeesch, J, et al. Prenatal management of the fetus with isolated congenital diaphragmatic hernia in the era of the TOTAL trial. Semin Fetal Neonatal Med. 2014; 19: 338–48.Google Scholar
Haynes, BF. Human thymic epithelium and T cell development: current issues and future directions. Thymus. 1990; 16: 143–57.Google Scholar
Pawlowski, TJ, Staerz, UD. Thymic education – T cells do it for themselves. Trends Immunol. 1994; 15: 205–9.Google Scholar
Liechty, KW, MacKenzie, TC, Shaaban, AF, Radu, A, Moseley, AM, Deans, R, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med. 2000; 6: 1282–6.Google Scholar
Maselli, KM, Badillo, A. Advances in fetal surgery. Ann Transl Med. 2016; 4: 394.Google Scholar
Kitagawa, H, Pringle, KC. Fetal surgery: a critical review. Pediatr Surg Int. 2017; 33: 421–33.Google Scholar
Partridge, EA, Davey, MG, Hornick, MA, McGovern, PE, Mejaddam, AY, Vrecenak, JD, et al. An extra-uterine system to physiologically support the extreme premature lamb. Nat Commun. 2017; 8: 15112.Google Scholar
Larson, BJ, Longaker, MT, Lorenz, HP. Scarless fetal wound healing: a basic science review. Plast Reconstr Surg. 2010; 126: 1172–80.Google Scholar
Yagi, LH, Watanuki, LM, Isaac, C, Gemperli, R, Nakamura, YM, Ladeira, PRS. Human fetal wound healing: a review of molecular and cellular aspects. Eur J Plastic Surg. 2016; 39: 239–46.Google Scholar
Hosper, NA, Eggink, AJ, Roelofs, LAJ, Wijnen, RMH, van Luyn, MJA, Bank, RA, et al. Intra-uterine tissue engineering of full-thickness skin defects in a fetal sheep model. Biomaterials. 2010; 31: 3910–19.Google Scholar
Xia, W, Noimark, S, Ourselin, S, West, SJ, Finlay, MC, David, AL, et al. Ultrasonic needle tracking with a fibre-optic ultrasound transmitter for guidance of minimally invasive fetal surgery. Med Image Comput Comput Assist Interv. 2017; 10434: 637–45.Google Scholar
Peter, L, Tella-Amo, M, Shakir, DI, Attilakos, G, Wimalasundera, R, Deprest, J, et al. Retrieval and registration of long-range overlapping frames for scalable mosaicking of in vivo fetoscopy. Int J Comput Assist Radiol Surg. 2018; 13: 713–20.Google Scholar
Watanabe, M, Kim, AG, Flake, AW. Tissue engineering strategies for fetal myelomeningocele repair in animal models. Fetal Diagn Ther. 2015; 37: 197–205.CrossRefGoogle ScholarPubMed
Fauza, DO, Jennings, RW, Teng, YD, Snyder, EY. Neural stem cell delivery to the spinal cord in an ovine model of fetal surgery for spina bifida. Surgery. 2008; 144: 367–73.Google Scholar
Peiro, JL, Fontecha, CG, Ruano, R, Esteves, M, Fonseca, C, Marotta, M, et al. Single-Access Fetal Endoscopy (SAFE) for myelomeningocele in sheep model I: Amniotic carbon dioxide gas approach. Surg Endosc Other Interv Tech. 2013; 27: 3835–40.Google Scholar
Brown, EG, Saadai, P, Pivetti, CD, Beattie, MS, Bresnahan, JC, Wang, A, et al. In utero repair of myelomeningocele with autologous amniotic membrane in the fetal lamb model. J Pediatr Surg. 2014; 49: 133–7; discussion 137–8.Google Scholar
Chen, YJ, Chung, K, Pivetti, C, Lankford, L, Kabagambe, SK, Vanover, M, et al. Fetal surgical repair with placenta-derived mesenchymal stromal cell engineered patch in a rodent model of myelomeningocele. J Pediatr Surg. 2018; 53: 183–88.CrossRefGoogle Scholar
Roelofs, LAJ, Eggink, AJ, Hulsbergen-van de Kaa, CA, van den Berg, PP, van Kuppevelt, TH, van Moerkerk, HTB, et al. Fetal abdominal wall repair with a collagen biomatrix in an experimental sheep model for gastroschisis. Tissue Eng Part A. 2008; 14: 2033–40.Google Scholar
Roelofs, LAJ, Geutjes, PJ, Van De Kaa, CAH, Eggink, AJ, Van Kuppevelt, TH, Daamen, WF, et al. Prenatal coverage of experimental gastroschisis with a collagen scaffold to protect the bowel. J Pediatr Surg. 2013; 48: 516–24.Google Scholar
Coughlin, MA, Werner, NL, Gajarski, R, Gadepalli, S, Hirschl, R, Barks, J, et al. Prenatally diagnosed severe CDH: mortality and morbidity remain high. J Pediatr Surg. 2016; 51: 1091–5.CrossRefGoogle ScholarPubMed
Deprest, J, Gucciardo, L, Eastwood, P, Zia, S, Jimenez, J, Russo, F, et al. Medical and regenerative solutions for congenital diaphragmatic hernia: A perinatal perspective. Eur J Pediatr Surg. 2014; 24: 270–7.Google ScholarPubMed
Fuchs, JR, Kaviani, A, Oh, JT, LaVan, D, Udagawa, T, Jennings, RW, et al. Diaphragmatic reconstruction with autologous tendon engineered from mesenchymal amniocytes. J Pediatr Surg. 2004; 39: 834–8.Google Scholar
Turner, CG, Klein, JD, Steigman, SA, Armant, M, Nicksa, GA, Zurakowski, D, et al. Preclinical regulatory validation of an engineered diaphragmatic tendon made with amniotic mesenchymal stem cells. J Pediatr Surg. 2011; 46: 57–61.Google Scholar
Pederiva, F, Ghionzoli, M, Pierro, A, De Coppi, P, Tovar, JA. Amniotic fluid stem cells rescue both in vitro and in vivo growth, innervation, and motility in nitrofen-exposed hypoplastic rat lungs through paracrine effects. Cell Transplant. 2013; 22: 1683–94.CrossRefGoogle ScholarPubMed
Lim, R, Malhotra, A, Tan, J, Chan, ST, Lau, S, Zhu, D, et al. First-in-human administration of allogeneic amnion cells in premature infants with bronchopulmonary dysplasia: a safety study. Stem Cells Transl Med. 2018; 7: 628–35.Google Scholar
Zani, A, Pierro, A, Elvassore, N, De Coppi, P. Tissue engineering: an option for esophageal replacement? Semin Pediatr Surg. 2009; 18: 57–62.Google Scholar
Lee, E, Milan, A, Urbani, L, De Coppi, P, Lowdell, MW. Decellularized material as scaffolds for tissue engineering studies in long gap esophageal atresia. Expert Opin Biol Ther. 2017; 17: 573–84.Google Scholar
Scottoni, F, Urbani, L, Camilli, C. D1.4 Oesophageal tissue engineering: preliminary evaluation of a 2 stage surgical approach in a mouse model. Arch Dis Child. 2017; 102 (A6).Google Scholar
Okuyama, H, Umeda, S, Takama, Y, Terasawa, T, Nakayama, Y. Patch esophagoplasty using an in-body-tissue-engineered collagenous connective tissue membrane. J Pediatr Surg. 2018; 53: 223–6.Google Scholar
Poghosyan, T, Sfeir, R, Michaud, L, Bruneval, P, Domet, T, Vanneaux, V, et al. Circumferential esophageal replacement using a tube-shaped tissue-engineered substitute: an experimental study in minipigs. Surgery. 2015; 158: 266–77.CrossRefGoogle ScholarPubMed
Catry, J, Luong-Nguyen, M, Arakelian, L, Poghosyan, T, Bruneval, P, Domet, T, et al. Circumferential esophageal replacement by a tissue-engineered substitute using mesenchymal stem cells: an experimental study in mini pigs. Cell Transplant. 2017; 26: 1831–9.CrossRefGoogle ScholarPubMed
Petsche Connell, J, Camci-Unal, G, Khademhosseini, A, Jacot, JG. Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications. Tissue Eng Part B Rev. 2013; 19: 368–79.CrossRefGoogle ScholarPubMed
Velasquez-Mao, AJ, Tsao, CJM, Monroe, MN, Legras, X, Bissig-Choisat, B, Bissig, KD, et al. Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells. PLoS One. 2017; 12: e0177824.Google Scholar
Nolan, HR, Gurria, J, Peiro, JL, Tabbah, S, Diaz-Primera, R, Polzin, W, et al. Congenital high airway obstruction syndrome (CHAOS): Natural history, prenatal management strategies, and outcomes at a single comprehensive fetal center. J Pediatr Surg. 2019; 54:1153–1158.CrossRefGoogle Scholar
Lange, P, Fishman, JM, Elliott, MJ, De Coppi, P, Birchall, MA. What can regenerative medicine offer for infants with laryngotracheal agenesis? Otolaryngol Head Neck Surg. 2011; 145: 544–50.Google Scholar
Atala, A, Bauer, SB, Soker, S, Yoo, JJ, Retik, AB. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet. 2006; 367: 1241–6.CrossRefGoogle ScholarPubMed
Corre, P, Merceron, C, Longis, J, Khonsari, RH, Pilet, P, Thi, TN, et al. Direct comparison of current cell-based and cell-free approaches towards the repair of craniofacial bone defects – a preclinical study. Acta Biomater. 2015; 26: 306–17.CrossRefGoogle ScholarPubMed
Steigman, SA, Ahmed, A, Shanti, RM, Tuan, RS, Valim, C, Fauza, DO. Sternal repair with bone grafts engineered from amniotic mesenchymal stem cells. J Pediatr Surg. 2009; 44: 1120–6.Google Scholar
Klein, JD, Turner, CGB, Ahmed, A, Steigman, SA, Zurakowski, D, Fauza, DO. Chest wall repair with engineered fetal bone grafts: an efficacy analysis in an autologous leporine model. J Pediatr Surg. 2010; 45: 1354–60.Google Scholar
Turner, CG, Klein, JD, Gray, FL, Ahmed, A, Zurakowski, D, Fauza, DO. Craniofacial repair with fetal bone grafts engineered from amniotic mesenchymal stem cells. J Surg Res. 2012; 178: 785–90.CrossRefGoogle ScholarPubMed
Ranzoni, AM, Corcelli, M, Hau, K-L, Kerns, JG, Vanleene, M, Shefelbine, S, et al. Counteracting bone fragility with human amniotic mesenchymal stem cells. Sci Rep. 2016; 6: 39656.CrossRefGoogle ScholarPubMed
Flake, AW, Harrison, MR, Adzick, NS, Zanjani, ED. Transplantation of fetal hematopoietic stem cells in utero: the creation of hematopoietic chimeras. Science. 1986; 233: 776–8.Google Scholar
Liechty, KW, Mackenzie, TC, Shaaban, AF, Radu, A, Moseley, AMB, Deans, R, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med. 2000; 6: 1282–6.Google Scholar

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