High-risk screening using breast MRI

Jeremy Price

doi:10.1017/CBO9781139084833.007

5 - High-risk screening using breast MRI

Published online by Cambridge University Press: 05 March 2012

Jeremy Price

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Jeremy Price: Affiliation:
The Canberra Hospital, Canberra, Australia

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Summary

Chapter outline

Introduction
Defining risk categories and identifying risk factors
Women in the high-risk category
Women in other risk subgroups
Principles and limitations of XRM screening
Performance of breast MRI in high-risk screening
Principles and limitations of high-risk screening using breast MRI
How long to screen for and at what internal

Introduction

The practical and the interpretative skills required to conduct a breast MRI program have been addressed in earlier chapters. In many centers, screening of women at high risk of breast cancer is now the commonest indication for performing breast MRI. This chapter will review breast screening concepts in general, and consider which women should be targeted for MRI screening. As gatekeepers of a precious resource, radiologists engaged in breast MRI screening, in close consultation with genetics experts and surgical colleagues, need to develop clear local guidelines on when MRI is considered appropriate. Other management options and issues relating to women at high risk of breast cancer are also addressed.

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Type: Chapter
Information: Handbook of Breast MRI , pp. 112 - 134

DOI: https://doi.org/10.1017/CBO9781139084833.007 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2011

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References

Saslow, DBoetes, CBurke, WAmerican Cancer Society guidelines for breast screening with MRI as an adjunct to mammographyCA Cancer J Clin 2007 57 75CrossRef Google Scholar PubMed

Berg, W ABeyond standard mammographic screening: mammography at age extremes, ultrasound, and MR imagingRadiol Clin North Am 2007 45 895CrossRef Google Scholar PubMed

National Breast and Ovarian Cancer Center (NBOCC)Breast Cancer Risk Factors: A Review of the EvidenceSurry Hills, NSWNational Breast and Ovarian Cancer Center 2009Google Scholar

Elmore, J GGigerenzer, GBenign breast disease – the risks of communicating riskN Engl J Med 2005 353 297CrossRef Google Scholar PubMed

Antoniou, APharoah, P D PNarod, S AAverage risks of breast and ovarian cancer associated with mutations in BRCA1 or BRCA2 detected in case series unselected for family history: a combined analysis of 22 studiesAm J Hum Genet 2003 72 1117CrossRef Google Scholar PubMed

Chen, SParmigiani, GMeta-analysis of BRCA1 and BRCA2 penetranceJ Clin Oncol 2007 25 1329CrossRef Google Scholar PubMed

Evans, D G RSusnerwala, IDawson, JRisk of breast cancer in male BRCA2 carriersJ Med Genet 2010 47 710CrossRef Google Scholar PubMed

Breast Cancer Linkage ConsortiumCancer risks in BRCA2 mutation carriersJ Natl Cancer Inst 1999 91 1310CrossRef Google Scholar

van Asperen, C JBrohet, R MMeijers-Heijboer, E JCancer risks in BRCA2 families: estimates for sites other than breast and ovaryJ Med Genet 2005 42 711CrossRef Google Scholar PubMed

Thompson, DEaston, D FThe Breast Cancer Linkage Consortium. Cancer incidence in BRCA1 mutation carriersJ Natl Cancer Inst 2002 94 1358CrossRef Google Scholar PubMed

Malone, K EBegg, C BHaile, R WPopulation-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2J Clin Oncol 2010 28 2404CrossRef Google Scholar PubMed

Lakhani, S Rvan de Vijver, M JJacquemier, JThe pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2J Clin Oncol 2002 20 2310CrossRef Google Scholar PubMed

Lidereau, REisinger, FChampeme, MMajor improvement in the efficacy of BRCA1 mutation screening using morphoclinical features of breast cancerCancer Res 2000 60 1206Google Scholar PubMed

Vargas, A CDa Silva, LLakhani, S RThe contribution of breast cancer pathology to statistical models to predict mutation risk in BRCA carriersFamilial Cancer 2010 9 545CrossRef Google Scholar PubMed

van Leeuwen, F EKlokman, W JStovall, MRoles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin’s diseaseJ Natl Cancer Inst 2003 95 971CrossRef Google Scholar PubMed

Travis, L BHill, D ADores, G MBreast cancer following RT and chemotherapy among young women with Hodgkin diseaseJAMA 2003 290 465CrossRef Google Scholar PubMed

Travis, L BHill, DDores, G MCumulative absolute breast cancer risk for young women treated for Hodgkin lymphomaJ Natl Cancer Inst 2005 97 1428CrossRef Google Scholar PubMed

Kenney, L BYasui, YInskip, P DBreast cancer after childhood cancer: a report from the childhood cancer survivor studyAnn Intern Med 2004 141 590CrossRef Google Scholar PubMed

Ralleigh, GGiven-Wilson, RBreast cancer risk and possible screening strategies for young women following supradiaphragmatic irradiation for Hodgkin’s diseaseClin Radiol 2004 59 647CrossRef Google Scholar PubMed

Clemons, MLoijens, LGoss, PBreast cancer risk following irradiation for Hodgkin’s diseaseCancer Treat Rev 2000 26 291CrossRef Google Scholar PubMed

Amir, EEvans, D GShenton, AEvaluation of breast cancer risk assessment packages in the family history evaluation and screening programmeJ Med Genet 2003 40 807CrossRef Google Scholar PubMed

Cuzick, JAssessing risk for breast cancerBreast Cancer Res 2008 10 S13CrossRef Google Scholar PubMed

Tyrer, JDuffy, S WCuzick, JA breast cancer prediction model incorporating familial and personal risk factorsStat Med 2004 23 111CrossRef Google Scholar PubMed

Mann, G JThorne, HBalleine, R LAnalysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resourceBreast Cancer Res 2006 8 R12CrossRef Google Scholar PubMed

Antoniou, A CHardy, RWalker, LPredicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinicsJ Med Genet 2008 45 425CrossRef Google Scholar PubMed

Collaborative Group on Hormonal Factors in Breast CancerFamilial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the diseaseLancet 2001 358 1389CrossRef Google Scholar

Arpino, GLaucirica, RElledge, R MPremalignant and in situ breast disease: biology and clinical implicationsAnn Intern Med 2005 143 446CrossRef Google Scholar PubMed

Port, E RPark, ABorgen, P IResults of MRI screening for breast cancer in high-risk patients with LCIS and atypical hyperplasiaAnn Surg Oncol 2007 14 1051CrossRef Google Scholar PubMed

McCormack, V Ados Santos, Silva IBreast density and parenchymal patterns as markers of breast cancer risk: a meta-analysisCancer Epidemiol Biomarkers Prev 2006 15 1159CrossRef Google Scholar PubMed

Boyd, N FDite, G SStone, JHeritability of mammographic density, a risk factor for breast cancerN Engl J Med 2002 347 886CrossRef Google Scholar PubMed

Martin, L JBoyd, N FMammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidenceBreast Cancer Res 2008 10 201CrossRef Google Scholar PubMed

Boyd, N FMartin, L JRommens, J MMammographic density: a heritable risk factor for breast cancerMethods Mol Biol 2009 472 343CrossRef Google Scholar PubMed

Martin, L JMelnichouk, OGuo, HFamily history, mammographic density, and risk of breast cancerCancer Epidemiol Biomarkers Prev 2010 19 456CrossRef Google Scholar PubMed

Odefrey, FStone, JGurrin, L CCommon genetic variants associated with breast cancer and mammographic density measures that predict diseaseCancer Res 2010 70 1449CrossRef Google Scholar PubMed

Boyd, N FGuo, HMartin, L JMammographic density and the risk and detection of breast cancerN Engl J Med 2007 356 227CrossRef Google Scholar PubMed

Kopans, D BBasic physics and doubts about relationship between mammographically determined tissue density and breast cancer riskRadiology 2008 246 348CrossRef Google Scholar PubMed

Duffy, F JNagtegaal, I DAstley, S MVisually assessed breast density, breast cancer risk and the importance of the craniocaudal viewBreast Cancer Res 2008 10 R64CrossRef Google Scholar PubMed

Baasch, MNielsen, S FEngholm, GBreast cancer incidence subsequent to surgical reduction of the female breastBr J Cancer 1996 73 961CrossRef Google Scholar PubMed

Kusano, A STrichopoulos, DTerry, K LA prospective study of breast size and premenopausal breast cancer incidenceInt J Cancer 2006 118 2031CrossRef Google Scholar PubMed

Fowble, BHanlon, AFreedman, GSecond cancers after conservative surgery and radiation for stages I-II breast cancer: identifying a subset of women at increased riskInt J Radiat Oncol Biol Phys 2001 51 679CrossRef Google Scholar PubMed

Gao, XFisher, S GEmami, BRisk of second primary cancer in the contralateral breast in women treated for early-stage breast cancer: a population-based studyInt J Radiat Oncol Biol Phys 2003 56 1038CrossRef Google Scholar PubMed

Morris, E ALiberman, LBallon, D JMRI of occult breast carcinoma in a high-risk populationAJR Am J Roentgenol 2003 181 619CrossRef Google Scholar

Sardanelli, FPodo, FD’Agnolo, GMulticenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT Study): interim resultsRadiology 2007 242 698CrossRef Google Scholar PubMed

Brennan, SLiberman, LDershaw, D DBreast MRI screening of women with a personal history of breast cancerAJR Am J Roentgenol 2010 195 510CrossRef Google Scholar PubMed

Hanrahan, E OGonzalez-Angulo, A MGiordano, S HOverall survival and cause-specific mortality of patients with stage T1a, bN0M0 breast carcinomaJ Clin Oncol 2007 25 4952CrossRef Google Scholar PubMed

Early Breast Cancer Trialists’ Collaborative Group (EBCTCG)Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trialsLancet 2005 365 1687CrossRef Google Scholar

Berry, D ACronin, K APlevritis, S KEffect of screening and adjuvant therapy on mortality from breast cancerN Engl J Med 2005 353 1784CrossRef Google Scholar PubMed

Gøtzsche, P CNielsen, MScreening for breast cancer with mammographyCochrane Database Syst Rev 2006 4 CD001877Google Scholar

Jørgensen, K JGøtzsche, P COverdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trendsBMJ 2009 339 2587CrossRef Google Scholar PubMed

Nelson, H DTyne, KNaik, AScreening for breast cancer: an update for the U.S. Preventive Services Task ForceAnn Intern Med 2009 151 727CrossRef Google Scholar PubMed

Mushlin, A IKouides, R WShapiro, D EEstimating the accuracy of screening mammography: a meta-analysisAm J Prev Med 1998 14 143CrossRef Google Scholar PubMed

Kolb, T MLichy, JNewhouse, J HComparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluationsRadiology 2002 225 165CrossRef Google Scholar PubMed

Leconte, IFeger, CGalant, CMammography and subsequent whole-breast sonography of nonpalpable breast cancers: the importance of radiologic breast densityAJR Am J Roentgenol 2003 180 1675CrossRef Google Scholar PubMed

Mandelson, M TOestreicher, NPorter, P LBreast density as a predictor of mammographic detection: comparison of interval- and screen-detected cancersJ Natl Cancer Inst 2000 92 1081CrossRef Google Scholar PubMed

Tilanus-Linthorst, MObdeijn, I MHop, W C JBRCA1 mutation and young age predict fast breast cancer growth in the Dutch, United Kingdom, and Canadian magnetic resonance imaging screening trialsClin Cancer Res 2007 13 7357CrossRef Google Scholar

Weedon-Fekjær, HLindqvist, B HVatten, L JBreast cancer tumor growth estimated through mammography screening dataBreast Cancer Res 2008 10 R41CrossRef Google Scholar PubMed

Moss, S MCuckle, HEvans, AEffect of mammographic screening from age 40 years on breast cancer mortality at 10 years’ follow-up: a randomised controlled trialLancet 2006 368 2053CrossRef Google Scholar PubMed

Armstrong, KMoye, EWilliams, SScreening mammography in women 40 to 49 years of age: a systematic review for the American College of PhysiciansAnn Intern Med 2007 146 516CrossRef Google Scholar PubMed

Berrington, de Gonzalez AReeves, GMammographic screening before age 50 years in the UK: comparison of the radiation risks with the mortality benefitsBr J Cancer 2005 93 590CrossRef Google Scholar

Elmore, J GBarton, M BMoceri, V MTen-year risk of false positive screening mammograms and clinical breast examinationsN Engl J Med 1998 338 1089CrossRef Google Scholar PubMed

Kavanagh, A MDavidson, NJolley, DDeterminants of false positive recall in an Australian mammographic screening programThe Breast 2006 15 510CrossRef Google Scholar

Christiansen, C LWang, FBarton, M BPredicting the cumulative risk of false-positive mammogramsJ Natl Cancer Inst 2000 92 1657CrossRef Google Scholar PubMed

Kosters, J PGøtzsche, P CRegular self-examination or clinical examination for early detection of breast cancerCochrane Database Syst Rev 2003 2 CD003373Google Scholar

DeMichele, AWeber, B LRisk management in BRCA1 and BRCA2 mutation carriers: lessons learned, challenges posedJ Clin Oncol 2002 20 1164CrossRef Google Scholar PubMed

Pisano, E DGatsonis, CHendrick, EDiagnostic performance of digital versus film mammography for breast-cancer screeningN Engl J Med 2005 353 1773CrossRef Google Scholar PubMed

Pisano, E DHendrick, R EYaffe, M JDiagnostic accuracy of digital versus film mammography: exploratory analysis of selected population subgroups in DMISTRadiology 2008 246 376CrossRef Google Scholar PubMed

Berg, W ABlume, J DCormack, J BCombined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancerJAMA 2008 299 2151CrossRef Google Scholar PubMed

Corsetti, VHoussami, NFerrari, ABreast screening with ultrasound in women with mammography-negative dense breasts: evidence on incremental cancer detection and false positives, and associated costEur J Cancer 2008 44 539CrossRef Google Scholar PubMed

Buchberger, WNiehoff, AObrist, PClinically and mammographically occult breast lesions: detection and classification with high resolution sonographySemin Ultrasound CT MR 2000 21 325CrossRef Google Scholar PubMed

Tilanus-Linthorst, MVerhoog, LObdeijn, IA BRCA1/2 mutation, high breast density and prominent pushing margins of a tumour independently contribute to a frequent false-negative mammographyInt J Cancer 2002 102 91CrossRef Google Scholar PubMed

Bigenwald, R ZWarner, EGunasekara, AIs mammography adequate for screening women with inherited BRCA mutations and low breast densityCancer Epidemiol Biomarkers Prev 2008 17 706CrossRef Google Scholar PubMed

Komeneka, I KDitkoff, BJoseph, KThe development of interval breast malignancies in patients with BRCA mutationsCancer 2004 100 2079CrossRef Google Scholar

Brekelmans, C T MSeynaeve, CBartels, C C MEffectiveness of breast cancer surveillance in BRCA1/2 gene mutation carriers and women with high familial riskJ Clin Oncol 2001 19 924CrossRef Google Scholar PubMed

Scheuer, LKauff, NRobson, MOutcome of preventive surgery and screening for breast and ovarian cancer in BRCA mutation carriersJ Clin Oncol 2002 20 1260CrossRef Google Scholar PubMed

Berg, W ATailored supplemental screening for breast cancer: what now and what nextAJR Am J Roentgenol 2009 192 390CrossRef Google Scholar PubMed

Andrieu, NEaston, D FChang-Claude, JEffect of chest x-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the International BRCA1/2 Carrier Cohort StudyJ Clin Oncol 2006 24 3361CrossRef Google Scholar PubMed

Berrington de, Gonzalez ABerg, C DVisvanathan, KEstimated risk of radiation-induced breast cancer from mammographic screening for young BRCA mutation carriersJ Natl Cancer Inst 2009 101 205CrossRef Google Scholar

Kuhl, C KSchmutzler, R KLeutner, C CBreast MR imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: preliminary resultsRadiology 2000 215 267CrossRef Google Scholar PubMed

Kuhl, C KSchrading, SLeutner, C CMammography, breast ultrasound, and magnetic resonance imaging for surveillance of women at high familial risk for breast cancerJ Clin Oncol 2005 23 8469CrossRef Google Scholar PubMed

Warner, EPlewes, D BHill, K ASurveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography and clinical breast examinationJAMA 2004 292 1317CrossRef Google Scholar PubMed

Kriege, MBrekelmans, C T MBoetes, CEfficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predispositionN Engl J Med 2004 351 427CrossRef Google Scholar PubMed

Leach, M OBoggis, A KDixon, A KScreening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicenter cohort study (MARIBS)Lancet 2005 365 1769Google Scholar

Warner, ECauser, P AMRI surveillance for hereditary breast-cancer riskLancet 2005 365 1747CrossRef Google Scholar PubMed

Kuhl, C KSchrading, SBieling, H BMRI for diagnosis of pure ductal carcinoma in situ: a prospective observational studyLancet 2007 370 485CrossRef Google Scholar PubMed

Obdeijn, I MLoo, C ERijnsburger, A JAssessment of false-negative cases of breast MR imaging in women with a familial or genetic predispositionBreast Cancer Res Treat 2010 119 399CrossRef Google Scholar PubMed

Causer, P AJong, R AWarner, EBreast cancers detected with imaging screening in the BRCA population: emphasis on MR imaging with histopathologic correlationRadioGraphics 2007 27 S165CrossRef Google Scholar PubMed

Granader, E JDwamena, BCarlos, R CMRI and mammography surveillance of women at increased risk for breast cancer: recommendations using an evidence-based approachAcad Radiol 2008 15 1590CrossRef Google Scholar PubMed

Schmutzler, R KRhiem, KBreuer, POutcome of a structured surveillance programme in women with a familial predisposition for breast cancerEur J Cancer Prev 2006 15 483CrossRef Google Scholar PubMed

Kuhl, CWeigel, SSchrading, SProspective multicenter cohort study to refine management recommendations for women at elevated familial risk of breast cancer: the EVA trialJ Clin Oncol 2010 28 1450CrossRef Google Scholar PubMed

Abramovici, GMainiero, M BScreening breast MR imaging: comparison of interpretation of baseline and annual follow-up studiesRadiology 2011 259 85CrossRef Google Scholar PubMed

Sardanelli, FPodo, FBreast MR imaging in women at high-risk of breast cancer. Is something changing in early breast cancer detectionEur Radiol 2007 17 873CrossRef Google Scholar PubMed

Lee, J MKopans, D BMcMahon, P MBreast cancer screening in BRCA1 mutation carriers: effectiveness of MR imaging – Markov Monte Carlo Decision AnalysisRadiology 2008 246 763CrossRef Google Scholar PubMed

Hamilton, L JEvans, A JCornford, E JWill MRI screening deliver the expected survival advantage in BRCA1 carriersClin Radiol 2009 64 1045CrossRef Google Scholar

Hagen, A IKvistad, K AMaehle, LSensitivity of MRI versus conventional screening in the diagnosis of BRCA-associated breast cancer in a national prospective seriesThe Breast 2007 16 367CrossRef Google Scholar

Smathers, S LBoone, J MLee, L JRadiation dose reduction for augmentation mammographyAJR Am J Roentgenol 2007 188 1414CrossRef Google Scholar PubMed

Miglioretti, D LRutter, C MGeller, B MEffect of breast augmentation on the accuracy of mammography and cancer characteristicsJAMA 2004 291 442CrossRef Google Scholar PubMed

Elwood, MMcNoe, BSmith, TOnce is enough – why some women do not continue to participate in a breast cancer screening programmeN Z Med J 1998 111 180Google Scholar PubMed

Miller, DLivingstone, VHerbison, G PInterventions for relieving the pain and discomfort of screening mammographyCochrane Database Syst Rev 2008 1 CD002942Google Scholar

Hall, F MThe rise and impending decline of screening mammographyRadiology 2008 247 597CrossRef Google Scholar PubMed

Kuhl, C KCurrent status of breast MR imaging. Part 2. Clinical applicationsRadiology 2007 244 672CrossRef Google Scholar PubMed

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