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Chapter 2 - Overview of frontotemporal dementia and its relationship to other neurodegenerative disorders

from Section 1 - Introduction to and brief history of FTD

Published online by Cambridge University Press:  05 May 2016

By
Paul McMonagle  and
Andrew Kertesz
Edited by
Bradford C. Dickerson
Bradford C. Dickerson
Affiliation:
Department of Neurology, Massachusetts General Hospital
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Hodges' Frontotemporal Dementia , pp. 15 - 29
Publisher: Cambridge University Press
Print publication year: 2016

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References

Pick, A. Über die Beziehungen der senilen Hirnatrophie zur Aphasie. Prag Med Wochenschr 1892;17:165–7.Google Scholar
Pick, A. Zur symptomatologie der linksseitigen Schlafenlappenatrophie. Monatsschr Psychiatr Neurol 1904;16:378–88.CrossRefGoogle Scholar
Snowden, J, Goulding, P, Neary, D. Semantic dementia: a form of circumscribed cerebral atrophy. Behav Neurol 1989;2:167–82.10.1155/1989/124043CrossRefGoogle Scholar
Hodges, JR, Patterson, K, Oxbury, S, Funnell, E. Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain 1992;115(Pt 6):1783–806.Google ScholarPubMed
Brun, A. Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology. Arch Gerontol Geriatr 1987;6(3):193–208.CrossRefGoogle ScholarPubMed
Neary, D, Snowden, JS, Northen, B, Goulding, P. Dementia of frontal lobe type. J Neurol Neurosurg Psychiatry 1988;51(3):353–61.CrossRefGoogle ScholarPubMed
Neary, D, Snowden, JS, Gustafson, L, Passant, U, Stuss, D, Black, S, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998;51(6):1546–54.10.1212/WNL.51.6.1546CrossRefGoogle ScholarPubMed
Mesulam, MM. Primary progressive aphasia – differentiation from Alzheimer's disease. Ann Neurol 1987;22(4):533–4.10.1002/ana.410220414CrossRefGoogle ScholarPubMed
Steele, JC, Richardson, JC, Olszewski, J. Progressive supranuclear palsy. A heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. Arch Neurol 1964;10:333–59.10.1001/archneur.1964.00460160003001CrossRefGoogle ScholarPubMed
Gibb, WR, Luthert, PJ, Marsden, CD. Corticobasal degeneration. Brain 1989;112(Pt 5):1171–92.10.1093/brain/112.5.1171CrossRefGoogle ScholarPubMed
Constantinidis, J, Richard, J, Tissot, R. Pick's disease. Histological and clinical correlations. Eur Neurol 1974;11(4):208–17.Google ScholarPubMed
Kertesz, A, Hudson, L, Mackenzie, IR, Munoz, DG. The pathology and nosology of primary progressive aphasia. Neurology 1994;44(11):2065–72.10.1212/WNL.44.11.2065CrossRefGoogle ScholarPubMed
Rascovsky, K, Hodges, JR, Knopman, D, Mendez, MF, Kramer, JH, Neuhaus, J, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011;134(Pt 9):2456–77.10.1093/brain/awr179CrossRefGoogle ScholarPubMed
Gregory, CA, Hodges, JR. Clinical features of frontal lobe dementia in comparison to Alzheimer's disease. J Neural Transm Suppl 1996;47:103–23.10.1007/978-3-7091-6892-9_6CrossRefGoogle ScholarPubMed
Cummings, JL, Duchen, LW. Kluver-Bucy syndrome in Pick disease: clinical and pathologic correlations. Neurology 1981;31(11):1415–22.10.1212/WNL.31.11.1415CrossRefGoogle ScholarPubMed
Miller, BL, Cummings, JL, Villanueva-Meyer, J, Boone, K, Mehringer, CM, Lesser, IM, et al. Frontal lobe degeneration: clinical, neuropsychological, and SPECT characteristics. Neurology 1991;41(9):1374–82.10.1212/WNL.41.9.1374CrossRefGoogle ScholarPubMed
Elfgren, C, Passant, U, Risberg, J. Neuropsychological findings in frontal lobe dementia. Dementia 1993;4(3–4):214–19.Google ScholarPubMed
Hodges, JR, Patterson, K, Ward, R, Garrard, P, Bak, T, Perry, R, et al. The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer's disease: a comparative neuropsychological study. Neuropsychology 1999;13(1):31–40.CrossRefGoogle ScholarPubMed
Graham, A, Davies, R, Xuereb, J, Halliday, G, Kril, J, Creasey, H, et al. Pathologically proven frontotemporal dementia presenting with severe amnesia. Brain 2005;128(Pt 3):597–605.10.1093/brain/awh348CrossRefGoogle ScholarPubMed
Kertesz, A, Davidson, W, McCabe, P, Munoz, D. Behavioral quantitation is more sensitive than cognitive testing in frontotemporal dementia. Alzheimer Dis Assoc Disord 2003;17(4):223–9.10.1097/00002093-200310000-00005CrossRefGoogle ScholarPubMed
Grossman, M, Mickanin, J, Onishi, K, Hughes, E, D'Esposito, M, Ding, XS, et al. Progressive nonfluent aphasia: language, cognitive, and PET measures contrasted with probable Alzheimer's disease. J Cogn Neurosci 1996;8(2):135–54.10.1162/jocn.1996.8.2.135CrossRefGoogle ScholarPubMed
Cohen, L, Benoit, N, Van Eeckhout, P, Ducarne, B, Brunet, P. Pure progressive aphemia. J Neurol Neurosurg Psychiatry 1993;56(8):923–4.10.1136/jnnp.56.8.923CrossRefGoogle ScholarPubMed
Mesulam, MM, Grossman, M, Hillis, A, Kertesz, A, Weintraub, S. The core and halo of primary progressive aphasia and semantic dementia. Ann Neurol 2003;54 Suppl 5:S11–14.CrossRefGoogle ScholarPubMed
Karbe, H, Kertesz, A, Polk, M. Profiles of language impairment in primary progressive aphasia. Arch Neurol 1993;50(2):193–201.10.1001/archneur.1993.00540020069020CrossRefGoogle ScholarPubMed
Weintraub, S, Rubin, NP, Mesulam, MM. Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features. Arch Neurol 1990;47(12):1329–35.10.1001/archneur.1990.00530120075013CrossRefGoogle ScholarPubMed
Gorno-Tempini, ML, Hillis, AE, Weintraub, S, Kertesz, A, Mendez, M, Cappa, SF, et al. Classification of primary progressive aphasia and its variants. Neurology 2011;76(11):1006–14.10.1212/WNL.0b013e31821103e6CrossRefGoogle ScholarPubMed
Josephs, KA, Duffy, JR, Strand, EA, Machulda, MM, Senjem, ML, Master, AV, et al. Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech. Brain 2012;135(Pt 5):1522–36.10.1093/brain/aws032CrossRefGoogle ScholarPubMed
Fukui, T, Sugita, K, Kawamura, M, Shiota, J, Nakano, I. Primary progressive apraxia in Pick's disease: a clinicopathologic study. Neurology 1996;47(2):467–73.10.1212/WNL.47.2.467CrossRefGoogle ScholarPubMed
Kertesz, A, McMonagle, P, Blair, M, Davidson, W, Munoz, DG. The evolution and pathology of frontotemporal dementia. Brain 2005;128(Pt 9):1996–2005.CrossRefGoogle ScholarPubMed
Appell, J, Kertesz, A, Fisman, M. A study of language functioning in Alzheimer patients. Brain Lang 1982;17(1):73–91.10.1016/0093-934X(82)90006-2CrossRefGoogle ScholarPubMed
Whiteley, AM, Warrington, EK. Prosopagnosia: a clinical, psychological, and anatomical study of three patients. J Neurol Neurosurg Psychiatry 1977;40(4):395–403.10.1136/jnnp.40.4.395CrossRefGoogle ScholarPubMed
Gorno-Tempini, ML, Dronkers, NF, Rankin, KP, Ogar, JM, Phengrasamy, L, Rosen, HJ, et al. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol 2004;55(3):335–46.10.1002/ana.10825CrossRefGoogle ScholarPubMed
Mesulam, M, Weintraub, S. Primary progressive aphasia: sharpening the focus on a clinical syndrome. In: Boller, F, Forrette, F, Khachaturian, Z, Poncet, M, Christen, Y, editors. Heterogeneity of Alzheimer's Disease Berlin: Springer-Verlag; 1992. p. 43–66.10.1007/978-3-642-46776-9_6CrossRefGoogle Scholar
Mesulam, M, Wicklund, A, Johnson, N, Rogalski, E, Léger, GC, Rademaker, A, et al. Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol 2008;63(6):709–19.Google ScholarPubMed
Harris, JM, Gall, C, Thompson, JC, Richardson, AM, Neary, D, du Plessis, D, et al. Classification and pathology of primary progressive aphasia. Neurology 2013;81(21):1832–9.CrossRefGoogle ScholarPubMed
Akelaitis, AJ. Atrophy of basal ganglia in Pick's disease. A clinicopathologic study. Arch Neurol Psychiatr 1944;51:27–34.10.1001/archneurpsyc.1944.02290250033002CrossRefGoogle Scholar
Munoz-Garcia, D, Ludwin, SK. Classic and generalized variants of Pick's disease: a clinicopathological, ultrastructural, and immunocytochemical comparative study. Ann Neurol 1984;16(4):467–80.CrossRefGoogle ScholarPubMed
Rebeiz, JJ, Kolodny, EH, Richardson, EP. Corticodentatonigral degeneration with neuronal achromasia. Arch Neurol 1968;18(1):20–33.CrossRefGoogle ScholarPubMed
Lang, AE, Bergeron, C, Pollanen, MS, Ashby, P. Parietal Pick's disease mimicking cortical-basal ganglionic degeneration. Neurology 1994;44(8):1436–40.CrossRefGoogle ScholarPubMed
Lippa, CF, Smith, TW, Fontneau, N. Corticonigral degeneration with neuronal achromasia. A clinicopathologic study of two cases. J Neurol Sci 1990;98(2–3):301–10.10.1016/0022-510X(90)90271-NCrossRefGoogle ScholarPubMed
Kertesz, A, Munoz, DG. Pick's Disease and Pick Complex New York; Chichester: J. Wiley & Sons; 1998.Google ScholarPubMed
Kertesz, A, Martinez-Lage, P, Davidson, W, Munoz, DG. The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. Neurology 2000;55(9):1368–75.10.1212/WNL.55.9.1368CrossRefGoogle ScholarPubMed
Armstrong, MJ, Litvan, I, Lang, AE, Bak, TH, Bhatia, KP, Borroni, B, et al. Criteria for the diagnosis of corticobasal degeneration. Neurology 2013;80(5):496–503.10.1212/WNL.0b013e31827f0fd1CrossRefGoogle ScholarPubMed
Pillon, B, Blin, J, Vidailhet, M, Deweer, B, Sirigu, A, Dubois, B, et al. The neuropsychological pattern of corticobasal degeneration: comparison with progressive supranuclear palsy and Alzheimer's disease. Neurology 1995;45(8):1477–83.10.1212/WNL.45.8.1477CrossRefGoogle ScholarPubMed
Feany, MB, Mattiace, LA, Dickson, DW. Neuropathologic overlap of progressive supranuclear palsy, Pick's disease and corticobasal degeneration. J Neuropathol Exp Neurol 1996;55(1):53–67.10.1097/00005072-199601000-00006CrossRefGoogle ScholarPubMed
Houlden, H, Baker, M, Morris, HR, MacDonald, N, Pickering-Brown, S, Adamson, J, et al. Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype. Neurology 2001;56(12):1702–6.10.1212/WNL.56.12.1702CrossRefGoogle Scholar
Dickson, DW, Bergeron, C, Chin, SS, Duyckaerts, C, Horoupian, D, Ikeda, K, et al. Office of Rare Diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol 2002;61(11):935–46.10.1093/jnen/61.11.935CrossRefGoogle ScholarPubMed
Mitsuyama, Y. Presenile dementia with motor neuron disease in Japan: clinico-pathological review of 26 cases. J Neurol Neurosurg Psychiatry 1984;47(9):953–9.10.1136/jnnp.47.9.953CrossRefGoogle ScholarPubMed
Neary, D, Snowden, JS, Mann, DM, Northen, B, Goulding, PJ, Macdermott, N. Frontal lobe dementia and motor neuron disease. J Neurol Neurosurg Psychiatry 1990;53(1):23–32.10.1136/jnnp.53.1.23CrossRefGoogle ScholarPubMed
Von Braumuhl, A. Picksche krankheit und amyotrophische lateralsklerose. Allgemeine Z Psychiatr Psychol Med 1932;96:364–6.Google Scholar
Lomen-Hoerth, C, Anderson, T, Miller, B. The overlap of amyotrophic lateral sclerosis and frontotemporal dementia. Neurology 2002;59(7):1077–9.10.1212/WNL.59.7.1077CrossRefGoogle ScholarPubMed
Strong, MJ, Lomen-Hoerth, C, Caselli, RJ, Bigio, EH, Yang, W. Cognitive impairment, frontotemporal dementia, and the motor neuron diseases. Ann Neurol 2003;54 Suppl 5:S20–3.10.1002/ana.10574CrossRefGoogle ScholarPubMed
Hodges, JR, Davies, R, Xuereb, J, Kril, J, Halliday, G. Survival in frontotemporal dementia. Neurology 2003;61(3):349–54.10.1212/01.WNL.0000078928.20107.52CrossRefGoogle ScholarPubMed
Okamoto, K, Hirai, S, Yamazaki, T, Sun, XY, Nakazato, Y. New ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with amyotrophic lateral sclerosis. Neurosci Lett 1991;129(2):233–6.10.1016/0304-3940(91)90469-ACrossRefGoogle ScholarPubMed
Jackson, M, Lennox, G, Lowe, J. Motor neurone disease-inclusion dementia. Neurodegeneration 1996;5(4):339–50.10.1006/neur.1996.0046CrossRefGoogle ScholarPubMed
Morita, M, Al-Chalabi, A, Andersen, PM, Hosler, B, Sapp, P, Englund, E, et al. A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia. Neurology 2006;66(6):839–44.10.1212/01.wnl.0000200048.53766.b4CrossRefGoogle ScholarPubMed
Vance, C, Al-Chalabi, A, Ruddy, D, Smith, BN, Hu, X, Sreedharan, J, et al. Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2–21.3. Brain 2006;129(Pt 4):868–76.10.1093/brain/awl030CrossRefGoogle Scholar
DeJesus-Hernandez, M, Mackenzie, IR, Boeve, BF, Boxer, AL, Baker, M, Rutherford, NJ, et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 2011;72(2):245–56.10.1016/j.neuron.2011.09.011CrossRefGoogle ScholarPubMed
Renton, AE, Majounie, E, Waite, A, Simón-Sánchez, J, Rollinson, S, Gibbs, JR, et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 2011;72(2):257–68.10.1016/j.neuron.2011.09.010CrossRefGoogle Scholar
Anderson, P. ALS and FTD: two sides of the same coin? Lancet Neurol 2013;12:937–8.Google Scholar
van Blitterswijk, M, DeJesus-Hernandez, M, Niemantsverdriet, E, Murray, ME, Heckman, MG, Diehl, NN, et al. Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study. Lancet Neurol 2013;12(10):978–88.10.1016/S1474-4422(13)70210-2CrossRefGoogle ScholarPubMed
Hodges, JR, Davies, RR, Xuereb, JH, Casey, B, Broe, M, Bak, TH, et al. Clinicopathological correlates in frontotemporal dementia. Ann Neurol 2004;56(3):399–406.10.1002/ana.20203CrossRefGoogle ScholarPubMed
Neumann, M, Sampathu, DM, Kwong, LK, Truax, AC, Micsenyi, MC, Chou, TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006;314(5796):130–3.10.1126/science.1134108CrossRefGoogle ScholarPubMed
Mackenzie, IR, Neumann, M, Baborie, A, Sampathu, DM, Du Plessis, D, Jaros, E, et al. A harmonized classification system for FTLD-TDP pathology. Acta Neuropathol 2011;122(1):111–13.10.1007/s00401-011-0845-8CrossRefGoogle ScholarPubMed
Munoz, DG, Neumann, M, Kusaka, H, Yokota, O, Ishihara, K, Terada, S, et al. FUS pathology in basophilic inclusion body disease. Acta Neuropathol 2009;118(5):617–27.10.1007/s00401-009-0598-9CrossRefGoogle ScholarPubMed
Neumann, M, Rademakers, R, Roeber, S, Baker, M, Kretzschmar, HA, Mackenzie, IR. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain 2009;132(Pt 11):2922–31.10.1093/brain/awp214CrossRefGoogle ScholarPubMed
Mackenzie, IR, Neumann, M, Bigio, EH, Cairns, NJ, Alafuzoff, I, Kril, J, et al. Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol 2009;117(1):15–18.10.1007/s00401-008-0460-5CrossRefGoogle ScholarPubMed
Snowden, JS, Rollinson, S, Thompson, JC, Harris, JM, Stopford, CL, Richardson, AM, et al. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain 2012;135(Pt 3):693–708.10.1093/brain/awr355CrossRefGoogle ScholarPubMed
Roberson, ED. Mouse models of frontotemporal dementia. Ann Neurol 2012;72(6):837–49.10.1002/ana.23722CrossRefGoogle ScholarPubMed
Munoz, DG, Woulfe, J, Kertesz, A. Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia. Acta Neuropathol 2007;114(4):347–57.10.1007/s00401-007-0266-xCrossRefGoogle ScholarPubMed
Josephs, KA, Hodges, JR, Snowden, JS, Mackenzie, IR, Neumann, M, Mann, DM, et al. Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathol 2011;122(2):137–53.10.1007/s00401-011-0839-6CrossRefGoogle ScholarPubMed
Rohrer, JD, Lashley, T, Schott, JM, Warren, JE, Mead, S, Isaacs, AM, et al. Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration. Brain 2011;134(Pt 9):2565–81.10.1093/brain/awr198CrossRefGoogle ScholarPubMed
Menon, R, Baborie, A, Jaros, E, Mann, DM, Ray, PS, Larner, AJ. What's in a name? Neuronal intermediate filament inclusion disease (NIFID), frontotemporal lobar degeneration-intermediate filament (FTLD-IF) or frontotemporal lobar degeneration-fused in sarcoma (FTLD-FUS)? J Neurol Neurosurg Psychiatry 2011;82(12):1412–14.10.1136/jnnp.2010.220947CrossRefGoogle ScholarPubMed
Mackenzie, IR, Foti, D, Woulfe, J, Hurwitz, TA. Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions. Brain 2008;131(Pt 5):1282–93.10.1093/brain/awn061CrossRefGoogle ScholarPubMed
Lesage, S, Le Ber, I, Condroyer, C, Broussolle, E, Gabelle, A, Thobois, S, et al. C9orf72 repeat expansions are a rare genetic cause of parkinsonism. Brain 2013;136(Pt 2):385–91.10.1093/brain/aws357CrossRefGoogle ScholarPubMed
Bozeat, S, Gregory, CA, Ralph, MA, Hodges, JR. Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? J Neurol Neurosurg Psychiatry 2000;69(2):178–86.CrossRefGoogle ScholarPubMed
Harris, JM, Gall, C, Thompson, JC, Richardson, AM, Neary, D, du Plessis, D, et al. Sensitivity and specificity of FTDC criteria for behavioral variant frontotemporal dementia. Neurology 2013;80(20):1881–7.10.1212/WNL.0b013e318292a342CrossRefGoogle ScholarPubMed
Alladi, S, Xuereb, J, Bak, T, Nestor, P, Knibb, J, Patterson, K, et al. Focal cortical presentations of Alzheimer's disease. Brain 2007;130(Pt 10):2636–45.10.1093/brain/awm213CrossRefGoogle ScholarPubMed
Chaal, S, Rowe, J. Dopamine transporter (dat) imaging can be normal with neuropathologically confirmed corticobasal degeneration. J Neurol Neurosurg Psychiatry 2013;84(11):e2.10.1136/jnnp-2013-306573.151CrossRefGoogle Scholar
Shelley, BP, Hodges, JR, Kipps, CM, Xuereb, JH, Bak, TH. Is the pathology of corticobasal syndrome predictable in life? Mov Disord 2009;24(11):1593–9.10.1002/mds.22558CrossRefGoogle Scholar
Mathew, R, Bak, TH, Hodges, JR. Diagnostic criteria for corticobasal syndrome: a comparative study. J Neurol Neurosurg Psychiatry 2012;83(4):405–10.10.1136/jnnp-2011-300875CrossRefGoogle ScholarPubMed
Tang-Wai, D, Lewis, P, Boeve, B, Hutton, M, Golde, T, Baker, M, et al. Familial frontotemporal dementia associated with a novel presenilin-1 mutation. Dement Geriatr Cogn Disord 2002;14(1):13–21.10.1159/000058328CrossRefGoogle ScholarPubMed
Halliday, GM, Song, YJ, Lepar, G, Brooks, WS, Kwok, JB, Kersaitis, C, et al. Pick bodies in a family with presenilin-1 Alzheimer's disease. Ann Neurol 2005;57(1):139–43.CrossRefGoogle Scholar
Dermaut, B, Kumar-Singh, S, Engelborghs, S, Theuns, J, Rademakers, R, Saerens, J, et al. A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques. Ann Neurol 2004;55(5):617–26.10.1002/ana.20083CrossRefGoogle Scholar
Irwin, DJ, McMillan, CT, Toledo, JB, Arnold, SE, Shaw, LM, Wang, LS, et al. Comparison of cerebrospinal fluid levels of tau and Aβ 1–42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms. Arch Neurol 2012;69(8):1018–25.10.1001/archneurol.2012.26CrossRefGoogle ScholarPubMed
Bathgate, D, Snowden, JS, Varma, A, Blackshaw, A, Neary, D. Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia. Acta Neurol Scand 2001;103(6):367–78.10.1034/j.1600-0404.2001.2000236.xCrossRefGoogle ScholarPubMed
Greene, JD, Hodges, JR, Ironside, JW, Warlow, CP. Progressive aphasia with rapidly progressive dementia in a 49 year old woman. J Neurol Neurosurg Psychiatry 1999;66(2):238–43.10.1136/jnnp.66.2.238CrossRefGoogle ScholarPubMed
Forman, MS, Farmer, J, Johnson, JK, Clark, CM, Arnold, SE, Coslett, HB, et al. Frontotemporal dementia: clinicopathological correlations. Ann Neurol 2006;59(6):952–62.10.1002/ana.20873CrossRefGoogle ScholarPubMed
Mead, S, Poulter, M, Beck, J, Webb, TE, Campbell, TA, Linehan, JM, et al. Inherited prion disease with six octapeptide repeat insertional mutation – molecular analysis of phenotypic heterogeneity. Brain 2006;129(Pt 9):2297–317.10.1093/brain/awl226CrossRefGoogle ScholarPubMed
Kipps, CM, Hodges, JR, Hornberger, M. Nonprogressive behavioural frontotemporal dementia: recent developments and clinical implications of the ‘bvFTD phenocopy syndrome’. Curr Opin Neurol 2010;23(6):628–32.10.1097/WCO.0b013e3283404309CrossRefGoogle ScholarPubMed
Piguet, O, Hornberger, M, Mioshi, E, Hodges, JR. Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management. Lancet Neurol 2011;10(2):162–72.10.1016/S1474-4422(10)70299-4CrossRefGoogle Scholar

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