Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-ndmmz Total loading time: 0 Render date: 2024-05-08T19:02:23.104Z Has data issue: false hasContentIssue false

Chapter 7

Published online by Cambridge University Press:  05 May 2022

R. John Aitken
Affiliation:
University of Newcastle, New South Wales
Get access

Summary

The Janus faces of IVFIn vitro fertilization therapy was originally pioneered by Edwards, Steptoe and Purdy in order to help women suffering from bilateral tubal occlusion. The subsequent rise of Assisted Reproductive Therapy (ART) as a default treatment for many different forms of human infertility has been successful to the point that it has now become a major industry that exists, not just to meet the needs of its desperate patients, but to satisfy the aspirations of its shareholders. The sheer scale of the demand for ART services in the future may create several issues that will have to be addressed, including the cost of providing equitable access to such therapy and meeting the long-term health needs of the children born as a result. When conducted at scale, the ART industry will also serve to retain poor fertility genes within the population. When combined with the lack of selection pressure on human fertility in advanced affluent societies, this feature will ensure that the incidence of infertility continues to rise, fuelling the need for more ART services in a self-perpetuating spiral. This may be a boon for business but will become a millstone for Governments trying to provide equitable access to healthcare services, including ART.

Type
Chapter
Information
The Infertility Trap
Why life choices impact your fertility and why we must act now
, pp. 238 - 269
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

7.6 References

Abbasihormozi, SH, Babapour, V, Kouhkan, A, et al. Stress hormone and oxidative stress biomarkers link obesity and diabetes with reduced fertility potential. Cell J 2019;21(3):307313.Google Scholar
Ainsworth, C, Nixon, B, Aitken, RJ. Development of a novel electrophoretic system for the isolation of human spermatozoa. Hum Reprod 2005;20(8):22612270.CrossRefGoogle ScholarPubMed
Aitken, RJ. Diagnostic value of the hamster oocyte penetration assay. Int J Androl 1984;7(4):273275.Google ScholarPubMed
Aitken, RJ. Reactive oxygen species as mediators of sperm capacitation and pathological damage. Mol Reprod Dev 2017;84(10):10391052.Google Scholar
Aitken, RJ. Not every sperm is sacred; a perspective on male infertility. Mol Hum Reprod 2018;24(6):287298.Google Scholar
Aitken, RJ. The male is significantly implicated as the cause of unexplained infertility. Semin Reprod Med 2020;38(1):320.Google Scholar
Aitken, RJ, Baker, MA, Nixon, B. Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress? Asian J Androl 2015;17(4):633639.CrossRefGoogle ScholarPubMed
Aitken, RJ, Bakos, HW. Should we be measuring DNA damage in human spermatozoa? New light on an old question. Hum Reprod 2021;36(5):11751185.Google Scholar
Aitken, RJ, Clarkson, JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil 1987;81(2):459469.Google Scholar
Aitken, RJ, Clarkson, JS. Significance of reactive oxygen species and antioxidants in defining the efficacy of sperm preparation techniques. J Androl 1988;9(6):367376.Google Scholar
Aitken, RJ, De Iuliis, GN, Nixon, B. The sins of our forefathers: paternal impacts on de novo mutation rate and development. Annu Rev Genet 2020;54:124.Google Scholar
Aitken, RJ, Gordon, E, Harkiss, D, et al. Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. Biol Reprod 1998;59(5):10371046.Google Scholar
Aitken, RJ, Irvine, DS, Wu, FC. Prospective analysis of sperm-oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynecol 1991;164(2):542551.Google Scholar
Aitken, RJ, Thatcher, S, Glasier, AF, et al. Relative ability of modified versions of the hamster oocyte penetration test, incorporating hyperosmotic medium or the ionophore A23187, to predict IVF outcome. Hum Reprod 1987;2(3):227231.Google Scholar
Aitken, RJ, Whiting, S, De Iuliis, GN, et al. Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase. J Biol Chem 2012;287(39):3304833060.Google Scholar
Assisted Reproductive Technology Surveillance and Research Team, Kissin, DM, Boulet, SL, Jamieson, DJ. Fertility treatments in the United States: improving access and outcomes. Obstet Gynecol 2016;128(2):387390.Google Scholar
Barberet, J, Binquet, C, Guilleman, M, et al. Do assisted reproductive technologies and in vitro embryo culture influence the epigenetic control of imprinted genes and transposable elements in children? Hum Reprod 2021;36:479492.Google Scholar
Belva, F, Bonduelle, M, Buysse, A, et al. Chromosomal abnormalities after ICSI in relation to semen parameters: results in 1114 fetuses and 1391 neonates from a single center. Hum Reprod 2020;35(9):21492162.Google Scholar
Bergh, C, Wennerholm, UB. Long-term health of children conceived after assisted reproductive technology. Ups J Med Sci 2020;125(2):152157.CrossRefGoogle ScholarPubMed
Berntsen, S, Söderström-Anttila, V, Wennerholm, UB, et al. The health of children conceived by ART: ‘the chicken or the egg?’. Hum Reprod Update 2019;25(2):137158.Google Scholar
Bhagwat, S, Sontakke, S, K D, Parte, P, Jadhav, S. Chemotactic behavior of spermatozoa captured using a microfluidic chip. Biomicrofluidics 2018;12(2):024112.CrossRefGoogle ScholarPubMed
Blakely, B, Williams, J, Mayes, C, Kerridge, I, Lipworth, W. Conflicts of interest in Australia’s IVF industry: an empirical analysis and call for action. Hum Fertil (Camb) 2019;22(4):230237.Google Scholar
Bolton, VN, Braude, PR. Preparation of human spermatozoa for in vitro fertilization by isopycnic centrifugation on self-generating density gradients. Arch Androl 1984;13(2–3):167176.Google Scholar
Boulet, SL, Mehta, A, Kissin, DM, et al. Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection. J Am Med Assoc 2015;313(3):255263.Google Scholar
Chronopoulou, E, Harper, JC. IVF culture media: past, present and future. Hum Reprod Update 2015;21(1):3955.Google Scholar
De Iuliis, GN, Newey, RJ, King, BV, Aitken, RJ. Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro. PLoS One 2009;4(7):e6446.CrossRefGoogle ScholarPubMed
Edwards, RG, Steptoe, PC, Purdy, JM. Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol 1980;87(9):737756.CrossRefGoogle ScholarPubMed
Evans, TC. Effects of hydrogen peroxide produced in the medium by radiation on spermatozoa of Arbacia punctulata. Biol Bull 1947;92(2):99109.Google Scholar
Fang, J, Zhang, J, Zhu, F, et al. Patients with acephalic spermatozoa syndrome linked to SUN5 mutations have a favorable pregnancy outcome from ICSI. Hum Reprod 2018;33(3):372377.Google Scholar
Fauque, P, De Mouzon, J, Devaux, A, et al. Do in vitro fertilization, intrauterine insemination or female infertility impact the risk of congenital anomalies in singletons? A longitudinal national French study. Hum Reprod 2021;36(3):808816.Google Scholar
Geng, T, Cheng, L, Ge, C, Zhang, Y. The effect of ICSI in infertility couples with non-male factor: a systematic review and meta-analysis. J Assist Reprod Genet 2020;37(12):29292945.Google Scholar
Hardiman, P, Thomas, M, Osgood, V, Vlassopoulou, V, Ginsburg, J. Are estrogen assays essential for monitoring gonadotropin stimulant therapy? Gynecol Endocrinol 1990;4:261269.CrossRefGoogle ScholarPubMed
Jiménez-Fernández, S, Gurpegui, M, Díaz-Atienza, F, et al. Oxidative stress and antioxidant parameters in patients with major depressive disorder compared to healthy controls before and after antidepressant treatment: results from a meta-analysis. J Clin Psychiatry 2015;76(12):16581667.Google Scholar
Johnson, MH. Robert Edwards: the path to IVF. Reprod Biomed Online 2011;23(2):245262.Google Scholar
Johnson, MH. A short history of in vitro fertilization (IVF). Int J Dev Biol 2019;63:8392.Google Scholar
Johnson, MH, Elder, K. The Oldham Notebooks: an analysis of the development of IVF 1969–1978. VI. Sources of support and patterns of expenditure. Reprod Biomed Soc Online 2015;1(1):5870.CrossRefGoogle ScholarPubMed
Johnson, MH, Franklin, SB, Cottingham, M, Hopwood, N. Why the Medical Research Council refused Robert Edwards and Patrick Steptoe support for research on human conception in 1971. Hum Reprod 2010;25(9):21572174.Google Scholar
Kissin, DM, Zhang, Y, Boulet, SL, et al. Association of Assisted Reproductive Technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children. Hum Reprod 2015;30(2):454465.Google Scholar
Kliesch, S, Behre, HM, Nieschlag, E. High efficacy of gonadotropin or pulsatile gonadotropin-releasing hormone treatment in hypogonadotropic hypogonadal men. Eur J Endocrinol 1994;131(4):347354.Google Scholar
Krzyściak, W, Papież, M, Bąk, E, et al. Sperm antioxidant biomarkers and their correlation with clinical condition and lifestyle with regard to male reproductive potential. J Clin Med 2020;9(6):1785.Google Scholar
Li, Z, Liu, W, Qiu, T, et al. The construction of an interfacial valve-based microfluidic chip for thermotaxis evaluation of human sperm. Biomicrofluidics 2014;8(2):024102.Google Scholar
Liang, S, Yang, J, Wu, H, Teng, X, Duan, T. Effects of chromosome 9 inversion on IVF/ICSI: a 7-year retrospective cohort study. Mol Genet Genomic Med 2019;7(9):e856.CrossRefGoogle ScholarPubMed
Luke, B, Brown, MB, Wantman, E, et al. The risk of birth defects with conception by ART. Hum Reprod 2021;36(1):116129.Google Scholar
Ma, K, Sharkey, A, Kirsch, S, et al. Towards the molecular localisation of the AZF locus: mapping of microdeletions in azoospermic men within 14 subintervals of interval 6 of the human Y chromosome. Hum Mol Genet 1992;1(1):2933.Google Scholar
MacLeod, J. The role of oxygen in the metabolism and motility of human spermatozoa. Am J Physiol 1943;138:512518.Google Scholar
Masschaele, T, Gerris, J, Vandekerckhove, F, De Sutter, P. Does transferring three or more embryos make sense for a well-defined population of infertility patients undergoing IVF/ICSI? Facts Views Vis Obgyn 2012;4(1):5158.Google Scholar
McPherson, NO, Vincent, AD, Pacella-Ince, L, Tremellen, K. Comparison of in vitro fertilisation/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age. J Assist Reprod Genet 2021;38(3):669678.Google Scholar
Moreau, J, Gatimel, N, Parinaud, J, Leandri, R. Results of intrauterine inseminations with two pooled sequential ejaculates in cases of oligozoospermia. Asian J Androl 2018;20(5):523524.Google ScholarPubMed
Nagvenkar, P, Zaveri, K, Hinduja, I. Comparison of the sperm aneuploidy rate in severe oligozoospermic and oligozoospermic men and its relation to intracytoplasmic sperm injection outcome. Fertil Steril 2005;84(4):925931.Google Scholar
Feedback. New Scientist November 22 1984, 45.Google Scholar
Nguyen-Powanda, P, Robaire, B. Oxidative stress and reproductive function in the aging male. Biology (Basel) 2020;9(9):282.Google Scholar
Ni, X, Wang, J, Lv, M, et al. A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia. J Assist Reprod Genet 2020;37(6):14311439.Google Scholar
Novoselsky Persky, M, Hershko-Klement, A, Solnica, A et al. Conventional ICSI vs. physiological selection of spermatozoa for ICSI (picsi) in sibling oocytes. Andrology 2021;9(3):873877.Google Scholar
Oladosu, OW, Biliaminu, SA, Abdulazeez, IM, et al. Assessment of seminal biomarker of lipid peroxidation among male partners of infertile couples at the university of ilorin teaching hospital, Nigeria. Niger Postgrad Med J 2018;25(2):9499.Google Scholar
Palermo, GD, O’Neill, CL, Chow, S, et al. Intracytoplasmic sperm injection: state of the art in humans. Reproduction 2017;154(6):F93F110.Google Scholar
Phillipson, GT, Petrucco, OM, Matthews, CD. Congenital bilateral absence of the vas deferens, cystic fibrosis mutation analysis and intracytoplasmic sperm injection. Hum Reprod 2000;15(2):431435.Google Scholar
Quinn, P. Enhanced results in mouse and human embryo culture using a modified human tubal fluid medium lacking glucose and phosphate. J Assist Reprod Genet 1995;12(2):97105.Google Scholar
Reijo, R, Alagappan, RK, Patrizio, P, Page, DC. Severe oligozoospermia resulting from deletions of azoospermia factor gene on Y chromosome. Lancet 1996;347(9011):12901293.Google Scholar
Rothschild, L. The respiration of sea urchin spermatozoa. J Exp Biol 1950;27(3–4):420436.Google Scholar
Rudak, E, Jacobs, PA, Yanagimachi, R. Direct analysis of the chromosome constitution of human spermatozoa. Nature 1978;274:911913.Google Scholar
Samarasinghe, SVAC, Krishnan, K, Naidu, R, et al. Parabens generate reactive oxygen species in human spermatozoa. Andrology 2018;6(4):532541.Google Scholar
Saunders, CM, Larman, MG, Parrington, J, et al. PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Development 2002;129(15):3533–44.Google Scholar
Sha, Y, Liu, W, Huang, X, et al. EIF4G1 is a novel candidate gene associated with severe asthenozoospermia. Mol Genet Genomic Med 2019a;7(8):e807.Google Scholar
Sha, YW, Wang, X, Su, ZY, et al. Patients with multiple morphological abnormalities of the sperm flagella harbouring CFAP44 or CFAP43 mutations have a good pregnancy outcome following intracytoplasmic sperm injection. Andrologia 2019b;51(1):e13151.Google Scholar
Shang, YL, Zhu, FX, Yan, J, et al. Novel DPY19L2 variants in globozoospermic patients and the overcoming this male infertility. Asian J Androl 2019;21(2):183189.Google ScholarPubMed
Smith, R, Vantman, D, Ponce, J, Escobar, J, Lissi, E. Total antioxidant capacity of human seminal plasma. Hum Reprod 1996;11(8):16551660.Google Scholar
Steptoe, PC, Edwards, RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet 1976;1(7965):880882.Google Scholar
Tavalaee, M, Nomikos, M, Lai, FA, Nasr-Esfahani, MH. Expression of sperm PLCζ and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion. Reprod Biomed Online 2018;36(3):348355.Google Scholar
Tiepolo, L, Zuffardi, O. Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum Genet 1976;34(2):119124.Google Scholar
Tosic, J, Walton, A. Formation of hydrogen peroxide by spermatozoa and its inhibitory effect of respiration. Nature 1946;158:485.Google Scholar
Tosic, J, Walton, A. Metabolism of spermatozoa: the formation and elimination of hydrogen peroxide by spermatozoa and effects on motility and survival. Biochem J 1950;47(2):199212.Google Scholar
Vujisic, S, Korac, P, Pavlica, M, Vujnovic, N, Dmitrovic, R. Chromosomal segregation in sperm of the Robertsonian translocation (21;22) carrier and its impact on IVF outcome. J Assist Reprod Genet 2020;37(1):231238.Google Scholar
Wallace, EM, Aitken, RJ, Wu, FC. Residual sperm function in oligozoospermia induced by testosterone enanthate administered as a potential steroid male contraceptive. Int J Androl 1992;15(5):416424.Google Scholar
Walters, JLH, De Iuliis, GN, Dun, MD, et al. Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress. Biol Reprod 2018;98(6):784794.Google Scholar
Wambergue, C, Zouari, R, Fourati Ben Mustapha, S, et al. Patients with multiple morphological abnormalities of the sperm flagella due to DNAH1 mutations have a good prognosis following intracytoplasmic sperm injection. Hum Reprod 2016;31(6):11641172.Google Scholar
Wang, J, Tang, H, Zou, Q, et al. Patient with CATSPER3 mutations-related failure of sperm acrosome reaction with successful pregnancy outcome from intracytoplasmic sperm injection (ICSI). Mol Genet Genomic Med 2021;9(2):e1579.Google Scholar
Winston, RM. The future of microsurgery in infertility. Clin Obstet Gynaecol 1978;5(3):607622.Google Scholar
World Health Organization. Laboratory Manual for the Examination and Processing of Human Semen. 5th edn. World Health Organization, 2010.Google Scholar
Wu, H, Wang, J, Cheng, H, et al. Patients with severe asthenoteratospermia carrying SPAG6 or RSPH3 mutations have a positive pregnancy outcome following intracytoplasmic sperm injection. J Assist Reprod Genet 2020;37(4):829840.Google Scholar
Wyrobek, AJ, Eskenazi, B, Young, S, et al. Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. Proc Natl Acad Sci USA 2006;103(25):96019606.Google Scholar
Yanagimachi, R, Yanagimachi, H, Rogers, BJ. The use of zona-free animal ova as a test-system for the assessment of the fertilizing capacity of human spermatozoa. Biol Reprod 1976;15(4):471476.Google Scholar
Zaferani, M, Cheong, SH, Abbaspourrad, A. Rheotaxis-based separation of sperm with progressive motility using a microfluidic corral system. Proc Natl Acad Sci USA 2018;115(33):82728277.Google Scholar
Zhao, S, Chen, T, Yu, M, et al. Novel WEE2 gene variants identified in patients with fertilization failure and female infertility. Fertil Steril 2019;111(3):519526.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Chapter 7
  • R. John Aitken, University of Newcastle, New South Wales
  • Book: The Infertility Trap
  • Online publication: 05 May 2022
  • Chapter DOI: https://doi.org/10.1017/9781108935593.008
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Chapter 7
  • R. John Aitken, University of Newcastle, New South Wales
  • Book: The Infertility Trap
  • Online publication: 05 May 2022
  • Chapter DOI: https://doi.org/10.1017/9781108935593.008
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Chapter 7
  • R. John Aitken, University of Newcastle, New South Wales
  • Book: The Infertility Trap
  • Online publication: 05 May 2022
  • Chapter DOI: https://doi.org/10.1017/9781108935593.008
Available formats
×