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Chapter 15 - Epigenetics and Human Assisted Reproduction

Published online by Cambridge University Press:  24 December 2019

Kay Elder  and
Brian Dale
By
John Huntriss
Kay Elder
Affiliation:
Bourn Hall Clinic, Cambridge
Brian Dale
Affiliation:
Centre for Assisted Reproduction, Naples
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Summary

During mammalian development the growth of the fetus is regulated by genetic information that is inherited from both the sperm and the oocyte. Apart from the clear differences that are associated with the X and Y chromosomes, the parental genetic contributions to the embryo also differ via a system of ‘epigenetic’ marks. The differences in function between the parental genomes, how gametes and preimplantation embryos are reprogrammed, and how these delicate processes may be affected by ART and infertility will be described in this chapter. A full understanding of the cellular and molecular biology of human reproduction must include a study of epigenetics and genomic imprinting.

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In-Vitro Fertilization , pp. 331 - 357
Publisher: Cambridge University Press
Print publication year: 2020

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