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Chapter 42 - Tumors of the liver

from Section V - Other considerations and issues in pediatric hepatology

Published online by Cambridge University Press:  05 March 2014

Dolores López-Terrada
Affiliation:
Baylor College of Medicine, Houston, TX, USA
Milton J. Finegold
Affiliation:
Department of Pathology and Immunology and Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
Frederick J. Suchy
Affiliation:
University of Colorado Medical Center
Ronald J. Sokol
Affiliation:
University of Colorado Medical Center
William F. Balistreri
Affiliation:
University of Cincinnati College of Medicine
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Publisher: Cambridge University Press
Print publication year: 2014

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References

López-Terrada, D, Finegold, MJ. Tumors of the liver. In Suchy, F, Sokol, RJ, Balistrieri, WF (eds.). Liver Disease in Children 3rd edn. Cambridge, UK: Cambridge University Press, 2008 pp. 943–974.Google Scholar
Meyers, R, Aronson, DC, von Schweinitz, D, Zimmermann, A, Malogolowkin, MH. Pediatric liver tumors. In Poplack, PPD (ed.). Principles and Practice of Pediatric Oncology, 6th edn. Philadelphia, PA: Lippincott, Williams & Wilkins, 2011, pp. 838–860.Google Scholar
Otte, JB, Meyers, R. PLUTO first report. Pediatr Transplant 2010;14:830–835.CrossRefGoogle ScholarPubMed
Weinberg, AG, Finegold, MJ. Primary hepatic tumors of childhood. Hum Pathol 1983;14:512–537.CrossRefGoogle ScholarPubMed
Stocker, JT. Hepatic tumors in children. In Suchy, FJ (ed.) Liver Disease in Children, 2nd edn. Philadelphia: Lippincott, Williams & Wilkins, 2001, pp. 915–948.Google ScholarPubMed
National Cancer Institute. SEER Cancer Statistics Review, 1975–2007. Bethesda, MD: National Cancer Institute, 2007 (, accessed 22 July 2013).Google Scholar
Darbari, A, Sabin, KM, Shapiro, CN, Schwarz, KB. Epidemiology of primary hepatic malignancies in US children. Hepatology 2003;38:560–566.CrossRefGoogle Scholar
Chang, MH. Cancer prevention by vaccination against hepatitis B. Rec Results Cancer Res 2009;181:85–94.CrossRefGoogle ScholarPubMed
Katzenstein, HM, Krailo, MD, Malogolowkin, MH, et al. Fibrolamellar hepatocellular carcinoma in children and adolescents. Cancer 2003;97:2006–2012.CrossRefGoogle ScholarPubMed
McLaughlin, CC, Baptiste, MS, Schymura, MJ, Nasca, PC, Zdeb, MS. Maternal and infant birth characteristics and hepatoblastoma. Am J Epidemiol. 2006;163:818–828.CrossRefGoogle ScholarPubMed
Spector, LG, Puumala, SE, Carozza, SE, et al. Cancer risk among children with very low birth weights. Pediatrics 2009;124:96–104.CrossRefGoogle ScholarPubMed
Ansell, P, Mitchell, CD, Roman, E, et al. Relationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS. Eur J Cancer 2005;41:741–748.CrossRefGoogle ScholarPubMed
Li, M, Shuman, C, Fei, YL, et al. GPC3 mutation analysis in a spectrum of patients with overgrowth expands the phenotype of Simpson–Golabi–Behmel syndrome. Am J Med Genet 2001;102:161–168.3.0.CO;2-O>CrossRefGoogle Scholar
Aretz, S, Koch, A, Uhlhaas, S, et al. Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations? Pediatr Blood Cancer 2006;47:811–818.CrossRefGoogle ScholarPubMed
Roy, A, Finegold, MJ. Hepatic neoplasia and metabolic diseases in children. Clin Liver Dis 2010;14:731–746.CrossRefGoogle ScholarPubMed
Evason, K, Bove, KE, Finegold, MJ, et al. Morphologic findings in progressive familial intrahepatic cholestasis 2 (PFIC2): correlation with genetic and immunohistochemical studies. Am J Surg Pathol 2011;35:687–696.CrossRefGoogle ScholarPubMed
Richter, A, Grabhorn, E, Schulz, A, et al. Hepatoblastoma in a child with progressive familial intrahepatic cholestasis. Pediatr Transplant 2005;9:805–808.CrossRefGoogle Scholar
Prokurat, A, Kluge, P, Kosciesza, A, et al. Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin. Med Pediatr Oncol 2002;39:510–518.CrossRefGoogle ScholarPubMed
Hadzic, N, Finegold, MJ. Liver neoplasia in children. Clin Liver Dis 2011;15:443–462.CrossRefGoogle ScholarPubMed
McCarville, MB, Kao, SC. Imaging recommendations for malignant liver neoplasms in children. Pediatr Blood Cancer 2006;46:2–7.CrossRefGoogle ScholarPubMed
Philip, I, Shun, A, McCowage, G, Howman-Giles, R. Positron emission tomography in recurrent hepatoblastoma. Pediatr Surg Int 2005;21:341–345.CrossRefGoogle ScholarPubMed
Boman, F, Bossard, C, Fabre, M, et al. Mesenchymal hamartomas of the liver may be associated with increased serum alpha foetoprotein concentrations and mimic hepatoblastomas. Eur J Pediatr Surg 2004;14:63–66.Google ScholarPubMed
Levy, M, Trivedi, A, Zhang, J, et al. Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver. Hum Pathol 2011 Sep 19.
Children’s Oncology Group. Website. (, accessed 24 July 2013).
Aronson, DC, Schnater, JM, Staalman, CR, et al. Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 study. J Clin Oncol 2005;23:1245–1252.CrossRefGoogle Scholar
Finegold, MJ, Lopez-Terrada, DH, Bowen, J, Washington, MK, Qualman, SJ. Protocol for the examination of specimens from pediatric patients with hepatoblastoma. Arch Pathol Lab Med 2007;131:520–529.Google ScholarPubMed
Wang, LL, Filippi, RZ, Zurakowski, D, et al. Effects of neoadjuvant chemotherapy on hepatoblastoma: a morphologic and immunohistochemical study. Am J Surg Pathol 2010;34:287–299.CrossRefGoogle ScholarPubMed
Biegel, JA, Tan, L, Zhang, F, et al. Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. Clin Cancer Res 2002;8:3461–3467.Google ScholarPubMed
Trobaugh-Lotrario, AD, Tomlinson, GE, Finegold, MJ, Gore, L, Feusner, JH. Small cell undifferentiated variant of hepatoblastoma: adverse clinical and molecular features similar to rhabdoid tumors. Pediatr Blood Cancer 2009;52:328–334.CrossRefGoogle ScholarPubMed
Trobaugh-Lotrario, AD, Finegold, MJ, Feusner, JH. Rhabdoid tumors of the liver: rare, aggressive, and poorly responsive to standard cytotoxic chemotherapy. Pediatr Blood Cancer 2011;57:423–428.CrossRefGoogle ScholarPubMed
Grazi, GL, Vetrone, G, d’Errico, A, et al. Nested stromal–epithelial tumor (NSET) of the liver: a case report of an extremely rare tumor. Pathol Res Pract 2010;206:282–286.CrossRefGoogle ScholarPubMed
Mo, JQ, Dimashkieh, HH, Bove, KE. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation. Hum Pathol 2004;35:200–209.CrossRefGoogle ScholarPubMed
Adler, B, Naheedy, J, Yeager, N, Nicol, K, Klamar, J. Multifocal epithelioid hemangioendothelioma in a 16-year-old boy. Pediatr Radiol 2005;35:1014–1018.CrossRefGoogle Scholar
Shehata, BM, Gupta, NA, Katzenstein, HM, et al. Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases. Pediatr Dev Pathol 2011;14:111–116.CrossRefGoogle ScholarPubMed
Bioulac-Sage, P, Laumonier, H, Sa Cunha, A, Balabaud, C. Hepatocellular adenomas. Liver Int 2009;29:142.CrossRefGoogle ScholarPubMed
Schneider, NR, Cooley, LD, Finegold, MJ, Douglass, EC, Tomlinson, GE. The first recurring chromosome translocation in hepatoblastoma: der(4)t(1;4)(q12;q34). Genes Chromosomes Cancer 1997;19:291–294.3.0.CO;2-J>CrossRefGoogle Scholar
Tomlinson, GE, Douglass, EC, Pollock, BH, Finegold, MJ, Schneider, NR. Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21. Genes Chromosomes Cancer 2005;44:177–184.CrossRefGoogle ScholarPubMed
Suzuki, M, Kato, M, Yuyan, C, et al. Whole-genome profiling of chromosomal aberrations in hepatoblastoma using high-density single-nucleotide polymorphism genotyping microarrays. Cancer Sci 2008;99:564–570.CrossRefGoogle ScholarPubMed
Cairo, S, Armengol, C, De Reynies, A, et al. Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell 2008;14:471–484.CrossRefGoogle ScholarPubMed
Zatkova, A, Rouillard, JM, Hartmann, W, et al. Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma. Genes Chromosomes Cancer 2004;39:126–137.CrossRefGoogle ScholarPubMed
Rountree, CB, Mishra, L, Willenbring, H. Stem cells in liver diseases and cancer: recent advances on the path to new therapies. Hepatology 2012;55:298–306.CrossRefGoogle ScholarPubMed
Thompson, MD, Monga, SP. WNT/beta-catenin signaling in liver health and disease. Hepatology 2007;45:1298–1305.CrossRefGoogle ScholarPubMed
Armengol, C, Cairo, S, Fabre, M, Buendia, MA. Wnt signaling and hepatocarcinogenesis: the hepatoblastoma model. Int J Biochem Cell Biol 2011;43:265–270.CrossRefGoogle ScholarPubMed
Ueda, Y, Hiyama, E, Kamimatsuse, A, et al. Wnt signaling and telomerase activation of hepatoblastoma: correlation with chemosensitivity and surgical resectability. J Pediatr Surg 2011;46:2221–2227.CrossRefGoogle ScholarPubMed
Huang, S, He, J, Zhang, X, et al. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis. 2006;27:1334–1340.CrossRefGoogle ScholarPubMed
Chavan, RS, Patel, KU, Roy, A, et al. Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma. Pediatr Blood Cancer 2012;58:1006–1007.CrossRefGoogle Scholar
Eichenmuller, M, Gruner, I, Hagl, B, et al. Blocking the hedgehog pathway inhibits hepatoblastoma growth. Hepatology 2009;49:482–490.CrossRefGoogle ScholarPubMed
Litten, JB, Chen, TT, Schultz, R, et al. Activated NOTCH2 is overexpressed in hepatoblastomas: an immunohistochemical study. Pediatr Dev Pathol 2011;14:378–383.CrossRefGoogle Scholar
Gray, SG, Eriksson, T, Ekstrom, C, et al. Altered expression of members of the IGF-axis in hepatoblastomas. Br J Cancer 2000;82:1561–1567.CrossRefGoogle ScholarPubMed
Prawitt, D, Enklaar, T, Gartner-Rupprecht, B, et al. Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith–Wiedemann syndrome with Wilms’ tumor. Nat Genet 2005;37:785–786; author reply 6–7.CrossRefGoogle Scholar
Adesina, AM, Lopez-Terrada, D, Wong, KK, et al. Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways. Hum Pathol 2009;40:843–853.CrossRefGoogle ScholarPubMed
Hartmann, W, Kuchler, J, Koch, A, et al. Activation of phosphatidylinositol-3′-kinase/AKT signaling is essential in hepatoblastoma survival. Clin Cancer Res 2009;15:4538–4545.CrossRefGoogle ScholarPubMed
Purcell, R, Childs, M, Maibach, R, et al. HGF/c-Met related activation of beta-catenin in hepatoblastoma. J Exp Clin Cancer Res 2011;30:96.CrossRefGoogle ScholarPubMed
Grotegut, S, Kappler, R, Tarimoradi, S, et al. Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation. Int J Oncol 2010;36:1261–1267.Google ScholarPubMed
Marquardt, JU, Factor, VM, Thorgeirsson, SS. Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications. J Hepatol 2010;53:568–577.CrossRefGoogle ScholarPubMed
Lee, JS, Heo, J, Libbrecht, L,et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 2006;12:410–416.CrossRefGoogle ScholarPubMed
Nagata, T, Takahashi, Y, Ishii, Y, et al. Transcriptional profiling in hepatoblastomas using high-density oligonucleotide DNA array. Cancer Genet Cytogenet 2003;145:152–160.CrossRefGoogle ScholarPubMed
Luo, JH, Ren, B, Keryanov, S, et al. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology 2006;44:1012–1024.CrossRefGoogle ScholarPubMed
Cairo, S, Wang, Y, de Reynies, A, et al. Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer. Proc Natl Acad Sci USA 2010;107:20471–20476.CrossRefGoogle ScholarPubMed
Errani, C, Zhang, L, Sung, YS, et al. A novel WWTR1–CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer 2011;50:644–653.CrossRefGoogle ScholarPubMed
Zimmermann, A, Lopez-Terrada, D. Pathology of Pediatric Liver Tumors. In Zimmermann, A, Perilongo, G, Malogolowkin, MH, Von Schweinitz, D (eds.) Pediatric Liver Tumors. Berlin: Springer, 2011, pp. 83–112.CrossRefGoogle Scholar
Malogolowkin, MH, Katzenstein, HM, Krailo, M, et al. Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology. A report From the Children’s Oncology Group. J Clin Oncol 2011;29:3301–3306.CrossRefGoogle ScholarPubMed
Lopez-Terrada, D, Gunaratne, PH, Adesina, AM, et al. Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors. Hum Pathol 2009;40:783–794.CrossRefGoogle ScholarPubMed
Li, YC, Deng, YH, Guo, ZH, et al. Prognostic value of hedgehog signal component expressions in hepatoblastoma patients. Eur J Med Res 2010;15:468–474.Google ScholarPubMed
Himes, RW, Raijman, I, Finegold, MJ, Russell, HV, Fishman, DS. Diagnostic and therapeutic role of endoscopic retrograde cholangiopancreatography in biliary rhabdomyosarcoma. World J Gastroenterol 2008;14:4823–4825.CrossRefGoogle ScholarPubMed
Zhou, XD, Tang, ZY, Yang, BH, et al. Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma. Cancer 2001;91:1479–1486.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Zsiros, J, Maibach, R, Shafford, E, et al. Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study. J Clin Oncol 2010;28:2584–2590.CrossRefGoogle ScholarPubMed
US National Cancer Institute. Protocols for Hepatoblastoma. Bethesda, MD: US National Cancer Institute, 2012 (. Accessed 24 July 2013).Google Scholar
Mazereeuw-Hautier, J, Hoeger, PH, Benlahrech, S, et al. Efficacy of propranolol in hepatic infantile hemangiomas with diffuse neonatal hemangiomatosis. J Pediatr 2010;157:340–342.CrossRefGoogle ScholarPubMed
Finegold, MJ, Egler, RA, Goss, JA, et al. Liver tumors: pediatric population. Liver Transplant 2008;14:1545–1556.CrossRefGoogle ScholarPubMed
Otte, JB, Pritchard, J, Aronson, DC, et al. Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. Pediatr Blood Cancer 2004;42:74–83.CrossRefGoogle ScholarPubMed
Reyes, JD, Carr, B, Dvorchik, I, et al. Liver transplantation and chemotherapy for hepatoblastoma and hepatocellular cancer in childhood and adolescence. J Pediatr 2000;136:795–804.CrossRefGoogle ScholarPubMed
Guo, WJ, Yu, EX, Liu, LM, et al. Comparison between chemoembolization combined with radiotherapy and chemoembolization alone for large hepatocellular carcinoma. World J Gastroenterol 2003;9:1697–1701.CrossRefGoogle ScholarPubMed
Guimaraes, M, Uflacker, R. Locoregional therapy for hepatocellular carcinoma. Clin Liver Dis 2011;15:395–421.CrossRefGoogle ScholarPubMed
Leung, TW, Tang, AM, Zee, B, et al. Factors predicting response and survival in 149 patients with unresectable hepatocellular carcinoma treated by combination cisplatin, interferon-alpha, doxorubicin and 5-fluorouracil chemotherapy. Cancer 2002;94:421–427.CrossRefGoogle ScholarPubMed
Patt, YZ, Hassan, MM, Lozano, RD, et al. Phase II trial of systemic continuous fluorouracil and subcutaneous recombinant interferon alfa-2b for treatment of hepatocellular carcinoma. J Clin Oncol 2003;21:421–427.CrossRefGoogle ScholarPubMed
Bei, R, Mizejewski, GJ. Alpha fetoprotein is more than a hepatocellular cancer biomarker: from spontaneous immune response in cancer patients to the development of an AFP-based cancer vaccine. Curr Mol Med 2011;11:564–581.CrossRefGoogle ScholarPubMed
Mascarenhas, RC, Sanghvi, AN, Friedlander, L, et al. Thalidomide inhibits the growth and progression of hepatic epithelioid hemangioendothelioma. Oncology 2004;67:471–475.CrossRefGoogle ScholarPubMed

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