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    Kedzior, Karina Karolina and Martin-Iverson, Mathew 2010. Association between Severity of Cannabis Dependence and Depression. Psychology, Vol. 01, Issue. 04, p. 233.

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  • Print publication year: 2004
  • Online publication date: December 2009

4 - The association between cannabis use and depression: a review of the evidence

Summary

Introduction

The association between cannabis and depression has not received as much attention as the links between cannabis use and psychosis. One of the reasons may be that the depressed are much less likely to come to the attention of treatment services than are those who are psychotic. Furthermore, some symptoms of cannabis dependence may mimic those of depression and so comorbid depression may go undiagnosed.

Rising rates of cannabis use (Donnelly and Hall, 1994; Hall et al., 1999; Degenhardt et al., 2000; Johns, 2001), depression (Andrews et al., 1998; Cicchetti and Toth, 1998) and suicide among young adults (Diekstra et al., 1995; Lynskey et al., 2000) have increased public concern about the role of substance abuse, including cannabis, in non-psychotic mental disorders. There has also been increasing advocacy for interventions to prevent and treat problematic cannabis use and depressed mood among young people. Given these parallel rises, recent speculation that the two may be linked is understandable.

Given the high prevalence of both cannabis use and depression there remains a question why any comorbid relationship has received little clinical attention? It may reflect a lack of association between the two. However, until recently, there was disagreement as to whether cannabis dependence (or problematic cannabis use) existed, with few treatments available. A lack of clinical attention may therefore have simply reflected a lack of services that might have detected an association. Lastly, due to its illegal status, cannabis use may remain unreported by clients presenting with depression.

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Marijuana and Madness
  • Online ISBN: 9780511543630
  • Book DOI: https://doi.org/10.1017/CBO9780511543630
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REFERENCES
Abel, E. (1971). Changes in anxiety feelings following marihuana smoking. Br. J. Addict., 66, 185–187
Ablon, S. L. and Goodwin, F. K. (1974). High frequency of dysphoric reactions to tetrahydrocannabinol among depressed patients. Am. J. Psychiatry, 131, 448–453
Alpert, J., Maddocks, A., Rosenbaum, J. and Fava, M. (1994). Childhood psychopathology retrospectively assessed among adults with early onset depression. J. Affect. Disord., 31, 165–171
American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn revised (DSM-IV;-R). Washington, DC: American Psychiatric Association
American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington, DC: American Psychiatric Association
Andrews, G., Mathers, C. and Sanderson, K. (1998). The burden of disease. Med. J. Aust., 169, 156–158
Angst, J. (1996). Comorbidity of mood disorders: a longitudinal prospective study. Br. J. Psychiatry, 168 (suppl. 30) 31–37
Anthony, J. C. and Helzer, J. (1991). Syndromes of drug abuse and dependence. In Psychiatric Disorders in America, ed. L. N. Robins and D. A. Regier, pp. 116–154. New York: The Free Press
Bardone, A.Moffitt, T., Caspi, A.et al. (1998). Adult physical health outcomes of adolescent girls with conduct disorder, depression, and anxiety. J. Am. Acad. Child Adolescent Psychiatry, 37, 594–601
Beautrais, A. L., Joyce, P. R. and Mulder, R. T. (1999). Cannabis abuse and serious suicide attempts. Addiction, 94, 1155–1164
Bell, J., Ward, J., Mattick, R. P. et al. (1995) An Evaluation of Private Methadone Clinics. Canberra: Australian Government Publishing Service
Berkson, J. (1946). Limitations of the application of fourfold table analysis to hospital data. Biometrics Bull., 2, 47–53
Best, D., Gossop, M., Greenood, J.et al. (1999). Cannabis use in relation to illicit drug use and health problems among opiate users in treatment. Drug Alcohol Rev., 18, 31–38
Blazer, D. (1995). Mood disorders: epidemiology. In Comprehensive Textbook of Psychiatry, VIth edn., vol. 1, ed. H. Kaplan and B. Sadock, pp. 1079–1089. Baltimore, MD: Williams and Wilkins
Bovasso, G. (2001). Cannabis abuse as risk factor for depressive symptoms. Am. J. Psychiatry, 158, 2033–2037
Bowers, M. (1998). Family history and early psychotogenic response to marijuana. J. Clin. Psychiatry, 59, 198–199
Boyd, J. H., Burke, J. D., Gruenberg, E.et al. (1984). Exclusion criteria of DSM-III: a study of co-occurrence of hierarchy-free syndromes. Arch. Gen. Psychiatry, 41, 983–989
Brady, K. T., Casto, S., Lydiard, R. B.et al. (1991). Substance abuse in an inpatient psychiatric sample. Am. J. Drug Alcohol Abuse, 17, 389–397
Brook, J. S., Cohen, P. and Brook, D. W. (1998). Longitudinal study of co-occurring psychiatric disorders and substance use. J. Am. Acad. Child Adolescent Psychiatry, 37, 322–330
Caron, C. and Rutter, M. (1991). Comorbidity in child psychopathology: concepts, issues and research strategies. J. Child Psychol. Psychiatry, 32, 1063–1080
Chen, C.-Y., Wagner, F. and Anthony, J. (2002). Marijuana use and the risk of major depressive episode: epidemiological evidence from the United States National Comorbidity Survey. Social Psychiatry Psychiatric Epidemiol., 37, 199–206
Cicchetti, D. and Toth, S. (1998). The development of depression in children and adolescents. Am. Psychol., 53, 221–241
Degenhardt, L., Lynskey, M. and Hall, W. (2000). Cohort trends in the age of initiation of drug use in Australia. Aust. NZ J. Public Health, 24, 421–426
Degenhardt, L., Hall, W. and Lynskey, M. (2001). The relationship between cannabis use, depression and anxiety among Australian adults: findings from the National Survey of Mental Health Well-Being. Social Psychiatry Psychiatric Epidemiol., 36, 219–227
Dhossche, D., Rich, C. and Isacsson, G. (2001). Psychoactive substances in suicides: comparison of toxicologic findings in two samples. Am. J. Forensic Med. Pathol., 22, 239–243
Diekstra, R., Kienhorst, C. and de Wilde, E. (1995). Suicide and suicidal behaviour among adolescents. In Psychosocial Disorders Among Young People: Time Trends and their Causes, ed. M. Rutter and D. J. Smith, pp. 686–761. Chichester: John Wiley
Donnelly, N. and Hall, W. (1994). Patterns of Cannabis Use in Australia. NCADA Monograph Series no. 27. Canberra: Australian Government Publishing Service
Estroff, T., Dackis, C., Gold, M. and Pottash, A. (1985). Drug abuse and bipolar disorders. Int. J. Psychiatry Med., 15, 37–40
Feinstein, A. R. (1970). The pre-therapeutic classification of comorbidity in chronic disease. J. Chronic Dis., 23, 455–468
Fergusson, D. M. and Horwood, L. J. (1997). Early onset cannabis use and psychosocial adjustment in young adults. Addiction, 92, 279–296
Fergusson, D. M. and Horwood, L. J. (2001). The Christchurch Health and Development Study: review of findings on child and adolescent mental health. Aust. NZ J. Psychiatry, 35, 287–296
Fergusson, D., Horwood, J. and Lawton, M. (1990). Vulnerability to childhood problems and family social background. J. Child Psychol. Psychiatry, 31, 1145–1160
Fergusson, D., Horwood, L. and Lynskey, M. (1994). Parental separation, adolescent psychopathology and problem behaviours. J. Am. Acad. Child Adolescent Psychiatry, 33, 1122–1131
Fergusson, D. M., Horwood, J. and Swain-Campbell, N. (2002). Cannabis use and psychosocial adjustment in adolescence and young adulthood. Addiction, 97, 1123–1135
Field, T., Diego, M. and Sanders, C. (2001). Adolescent suicidal ideation. Adolescence, 36, 241–248
Fu, Q., Heath, A. C., Bucholz, K. K.et al. (2002). Shared genetic risk of major depression, alcohol dependence and marijuana dependence: the contribution from antisocial personality disorder in men. Arch. Gen. Psychiatry, 59, 1125–1132
Galaif, E., Chou, C.-P., Sussman, S. and Dent, C. (1998). Depression, suicidal ideation, and substance use among continuation high school students. J. Youth Adolescence, 27, 275–299
Galbaud Du Fort, G., Newman, S. and Bland, R. (1993). Psychiatric comorbidity and treatment seeking: sources of selection bias in the study of clinical populations. J. Nerv. Ment. Dis., 181, 464–474
Gale, E. N. and Guenther, G. (1971). Motivational factors associated with the use of cannabis (marihuana). Br. J. Addict., 66, 188–194
Grant, B. F. (1995). Comorbidity between DSM-IV drug use disorders and major depression: results of a national survey of adults. J. Substance Abuse, 7, 481–497
Green, B. E. and Ritter, C. (2000). Marijuana use and depression. J. Health Social Behav., 41, 40–49
Grinspoon, L. and Bakalar, J. B. (1998). The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research. J. Psychoactive Drugs, 30, 171–177
Gruber, A. J., Pope, H. G. and Oliva, P. (1997). Very long-term users of marijuana in the United States: a pilot study. Substance Use Misuse, 32, 249–264
Hall, W., Johnston, L. and Donnelly, N. (1999). Epidemiology of cannabis use and its consequences. In The Health Effects of Cannabis, ed. H. Kalant, W. Corrigall, W. Hall and R. Smart, pp. 71–125. Toronto, Canada: Centre for Addiction and Mental Health
Hall, W., Degenhardt, L. and Lynskey, M. (2001). The Health and Psychological Consequences of Cannabis Use. NCADA Monongraph no. 44. Canberra: Australian Publishing Service
Hofstra, M., Ende, J. and Verhultz, F. (2002). Child and adolescent problems predict DSM-IV disorders in adulthood: a 14-year follow-up of a Dutch epidemiological sample. J. Am. Acad. Child Adolescent Psychiatry, 41, 182–189
Holden, R. and Pakula, I. (2001). Marijuana, stress and suicide: a neuroimmunological explanation. Aust. NZ J. Psychiatry, 36, 465–466
Institute of Medicine (1996). Pathways of Addiction. Washington, DC: National Academy Press
Jablensky, A.Sartorius, N. and Ernberg, G. (1991). Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol. Med. (suppl. 20)
Johns, A. (2001). Psychiatric effects of cannabis. Br. J. Psychiatry, 178, 116–122
Kandel, D. B. (1984). Marijuana users in young adulthood. Arch. Gen. Psychiatry, 41, 200–209
Kandel, D. and Chen, K. (2000). Types of marijuana users by longitudinal course. J. Studies Alcohol, 61, 367–378
Kandel, D. and Davies, M. (1986). Adult sequelae of adolescent depressive symptoms. Arch. Gen. Psychiatry, 43, 255–262
Kandel, D. B., Davies, M., Karus, D. and Yamaguchi, K. (1986). The consequences in young adulthood of adolescent drug involvement. Arch. Gen. Psychiatry, 43, 746–754
Kandel, D., Chen, K., Warner, L. A., Kessler, R. C. and Grant, B. (1997). Prevalence and demographic correlates of symptoms of last year dependence on alcohol, nicotine, marijuana and cocaine in the U.S. population. Drug Alcohol Dependence, 44, 11–29
Kelder, S., Murray, N., Orpinas, P.et al. (2001). Depression and substance use among minority middle-school students. Am. J. Public Health, 91, 761–766
Kendler, K. S. (2001). Twin studies of psychiatric illness: an update. Arch. Gen. Psychiatry, 58, 1005–1014
Kendler, K. S. and Prescott, C. A. (1998). Cannabis use, abuse, and dependence in a population-based sample of female twins. Am. J. Psychiatry, 155, 1016–1022
Kendler, K., Neale, M., MacLean, C.et al. (1993a). Smoking and major depression: a causal analysis. Arch. Gen. Psychiatry, 50, 36–43
Kendler, K. S., Heath, A. C., Neale, M. C., Kessler, R. C. and Eaves, L. J. (1993b). Alcoholism and major depression in women. A twin study of the causes of comorbidity. Arch. Gen. Psychiatry, 50, 690–698
Kendler, K., Karkowski, L., Neale, M. and Prescott, C. (2000). Illicit psychoactive substance use, heavy use, abuse and dependence in a US population-based sample of male twins. Arch. Gen. Psychiatry, 57, 261–269
Kessler, R. C. (1995). Epidemiology of psychiatric comorbidity. In Textbook in Psychiatric Epidemiology, ed. M. T. Tsuang, M. Tohen and G. E. P. Zahner, pp. 179–197. New York: Wiley
Kessler, R. C., McGonagle, K. A., Zhao, S.et al. (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch. Gen. Psychiatry, 51, 8–19
Kessler, R. C., Nelson, C. B., McGonagle, K. A., et al. (1996). The epidemiology of co-occurring addictive and mental disorders: implications for prevention and service utilization. Am. J. Orthopsychiatry, 66, 17–31
Klein, D. and Riso, L. (1994). Psychiatric disorders: problems of boundaries and comorbidity. In Basic Issues in Psychopathology, ed. G. Costello, pp. 19–66. New York: Guilford
Kotin, J., Post, R. and Goodwin, F. (1973). Δ9-Tetrahydrocannabinol in depressed outpatients. Arch. Gen. Psychiatry, 28, 345–348
Kouri, E., Pope, H., Yurgelun-Todd, D. and Gruber, S. (1995). Attributes of heavy vs. occasional marjiuana smokers in a college population. Biol. Psychiatry, 38, 475–481
Lynskey, M. and Hall, W. (2000). The effects of adolescent cannabis use on educational attainment: a review. Addiction, 95, 1621–1630
Lynskey, M., Degenhardt, L. and Hall, W. (2000). Cohort trends in youth suicide in Australia 1964 to 1997. Aust. NZ J. Psychiatry, 34, 408–412
Lynskey, M. T., Heath, A. C., Nelson, E. C.et al. (2002). Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. Psychol. Med., 32, 195–207
Marken, P., Stanislav, S.et al. (1992). Profile of a sample of subjects admitted to an acute care psychiatric facility with manic symptoms. Psychopharmacol. Bull., 28, 201–205
Mathew, R., Wilson, W. and Tant, S. (1989). Acute changes in cerebral blood flow associated with marijuana smoking. Acta Psychiatr. Scand., 79, 118–128
McGee, R., Williams, S., Poulton, R. and Moffitt, T. (2000). A longitudinal study of cannabis use and mental health from adolescence to early adulthood. Addiction, 95, 491–503
Merikangas, K. and Angst, J. (1995). The challenge of depressive disorders in adolescence. In Psychosocial Disturbances in Young People, ed. M. Rutter, Cambridge: Cambridge University Press
Milich, R., Lynam, D.Zimmerman, R.et al. (2000). Differences in young adult psychopathology among drug abstainers, experimenters, and frequent users. J. Substance Abuse, 11, 69–88
Miller, F., Busch, F. and Tanenbaum, J. (1989). Drug abuse in schizophrenia and bipolar disorder. Am. J. Drug Alcohol Abuse, 15, 291–295
Miller-Johnson, S., Lochman, J., Coie, J., Terry, R. and Hyman, C. (1998). Comorbidity of conduct and depressive problems at sixth grade: substance use outcomes across adolescence. J. Abnormal Child Psychol., 26, 221–232
Mueser, K., Yarnold, P. and Bellack, A. (1992). Diagnostic and demographic correlates of substance abuse in schizophrenia and major affective disorder. Acta Psychiatr. Scand., 85, 48–55
Mueser, K. T., Drake, R. E. and Wallach, M. A. (1998). Dual diagnosis: a review of etiological theories. Addict. Behav., 23, 717–734
Musty, R. E. and Kaback, L. (1995). Relationships between motivation and depression in chronic marijuana users. Life Sci., 56, 2151–2158
Neale, M. C. and Kendler, K. S. (1995). Models of comorbidity for multifactorial disorders. Am. J. Hum. Genet., 57, 935–953
Paton, S., Kessler, R. and Kandel, D. (1977). Depressive mood and adolescent illicit drug use: a longitudinal analysis. J. Genet. Psychol., 131, 267–289
Patton, G., Coffey, C., Carlin, J.et al. (2002). Cannabis use and mental health in young people: cohort study. Br. Med. J., 325, 1195–1198
Pond, D. (1948). Psychological effects in depressive patients of the marijuana homologue, synhexyl. J. Neurol., Neurosurg. Psychiatry, 11, 271–279
Rey, J., Sawyer, M., Clark, J. and Baghurst, P. (2001). Depression among Australian adolescents. Med. J. Aust., 175, 19–23
Rey, J., Sawyer, M., Raphael, B., Patton, G. and Lynskey, M. (2002). Mental health of teenagers who use cannabis: results of an Australian survey. Br. J. Psychiatry, 180, 216–221
Roberts, R. S., Spitzer, W. O., Delmore, T. and Sackett, D. L. (1978). An empirical demonstration of Berkson's bias. J. Chron. Dis., 31, 119–128
Rowe, M., Fleming, M., Barry, K., Manwell, L. and Kropp, S. (1995). Correlates of depression in primary care. J. Fam. Pract., 41, 551–558
Rutter, M. (1987). Parental mental disorder as a psychiatric risk factor. In Psychiatric Update: American Psychiatric Association: Annual Review, vol. 6, ed. R. Hales and A. Frances, pp. 647–663. Washington, DC: American Psychiatric Press
Rutter, M., Pickles, A., Murray, R. and Eaves, L. (2001). Testing hypotheses on specific environmental causal effects on behavior. Psychol. Bull., 127, 291–324
Shedler, J. and Block, J. (1990). Adolescent drug use and psychological health: a longitudinal inquiry. Am. Psychol., 45, 612–630
Sonne, S., Brady, K. and Morton, W. (1994). Substance abuse and bipolar affective disorder. J. Nerv. Ment. Dis., 182, 349–352
Stoll, A., Cole, J. and Lukas, S. (1991). A case of mania as a result of fluoxetine–marijuana interaction. J. Clin. Psychiatry, 52, 280–281
Sullivan, P. F., Neale, M. C. and Kendler, K. S. (2000). Genetic epidemiology of major depression: review and meta-analysis. Am. J. Psychiatry, 157, 1552–1562
Troisi, A., Pasini, A., Saracco, M. and Spalletta, G. (1998). Psychiatric symptoms in male cannabis users not using other illicit drugs. Addiction, 93, 487–492
Velez, C., Johnson, J. and Cohen, P. (1989). A longitudinal analysis of selected risk factors for childhood psychopathology. J. Am. Acad. Child Adolescent Psychiatry, 28, 861–864
Warner, R., Taylor, D. and Wright, J. (1994). Substance use among the mentally ill: prevalence, reasons for use and effects on illness. Am. J. Orthopsychiatry, 74, 30–39
Weissman, M. Livingston Bruce, M., Leaf, P. Florio, L. and Holzer, C. (1991). Affective disorders. In Psychiatric Disorders in America, ed. L. Robins and D. Regier, pp. 53–80. New York: MacMillan
Weissman, M. M., Wolk, S., Wickramaratne, P.et al. (1999). Children with prepubertal-onset major depressive disorder and anxiety grown up. Arch. Gen. Psychiatry, 56, 794–801
Zablocki, B., Aidala, A., Hansell, S. and White, H. (1991). Marijuana use, introspectiveness, and mental health. J. Health Social Behav., 32, 65–79
Zelwer, A. (1994). Depression and marijuana. Aust. and NZ J. Psychiatry, 28, 528