Book contents
- Frontmatter
- Contents
- List of patient vignettes
- Preface
- Acknowledgments
- 1 Melancholia: a conceptual history
- 2 Melancholia defined
- 3 Defining melancholia by psychopathology
- 4 Defining melancholia: laboratory tests
- 5 Examination for melancholia
- 6 The differential diagnosis of melancholia
- 7 Suicide in melancholia
- 8 Electroconvulsive therapy for melancholia
- 9 Achieving effective ECT
- 10 The validity of the pharmacotherapy literature in melancholia
- 11 Basic pharmacotherapy for melancholic patients
- 12 Pharmacotherapy for melancholic patients in complicating circumstances
- 13 Proposed treatments for melancholia
- 14 The pathophysiology of melancholia
- 15 Future directions
- References
- Index
9 - Achieving effective ECT
Published online by Cambridge University Press: 14 August 2009
- Frontmatter
- Contents
- List of patient vignettes
- Preface
- Acknowledgments
- 1 Melancholia: a conceptual history
- 2 Melancholia defined
- 3 Defining melancholia by psychopathology
- 4 Defining melancholia: laboratory tests
- 5 Examination for melancholia
- 6 The differential diagnosis of melancholia
- 7 Suicide in melancholia
- 8 Electroconvulsive therapy for melancholia
- 9 Achieving effective ECT
- 10 The validity of the pharmacotherapy literature in melancholia
- 11 Basic pharmacotherapy for melancholic patients
- 12 Pharmacotherapy for melancholic patients in complicating circumstances
- 13 Proposed treatments for melancholia
- 14 The pathophysiology of melancholia
- 15 Future directions
- References
- Index
Summary
Practice makes perfect.
Remission of melancholia is achieved in 80–95% of patients treated with electroconvulsive therapy (ECT). Lesser remission rates, however, are commonly reported. What accounts for the differences in clinical outcome?
The technical practice of ECT is complex and not all treatment courses are optimized to assure the maximum therapeutic benefit. Inappropriate frequency and inadequate numbers of treatments, energies too low to assure an effective seizure, elevated seizure thresholds, inefficient electrode placements, and missed or incomplete seizures result in courses of treatment with limited benefit.
Patient selection
Convulsive therapy relieves depressive mood disorders, yet the benefits are best established in those with melancholia. The relief of severe disorders in mood was discovered early in ECT history. In patients with both the depressed and manic phases of “manic-depressive insanity” and “involutional depression,” the introduction of ECT was quickly identified as a life-saving treatment. To assure proper selection of patients, an intensive search for predictors of good response examined identifiable symptoms and syndromes, demographic features, severity of illness, and duration of illness. An excellent and rapid clinical response found in melancholia of recent onset with severe vegetative signs, suicide intent, and delusional thinking occurred in older rather than younger patients. A poor outcome was associated with chronic illness, limited impairment that allowed sustained employment, comorbid personality disorder, “neurotic symptoms” (pervasive anxiety, dysthymia, hypochondriasis), and substance abuse. Specific behavior-rating scales designed as predictors were developed.
- Type
- Chapter
- Information
- MelancholiaThe Diagnosis, Pathophysiology and Treatment of Depressive Illness, pp. 181 - 195Publisher: Cambridge University PressPrint publication year: 2006