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5 - Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for Down syndrome

Published online by Cambridge University Press:  05 July 2011

By
Adam Golabek ,
Katarzyna Jarząbek ,
Sonia Palminiello ,
Marius Walus ,
Ausma Rabe ,
Giorgio Albertini  and
Elizabeth Kida
Edited by
Jean-Adolphe Rondal ,
Juan Perera  and
Donna Spiker
Adam Golabek
Affiliation:
Institute for Basic Research in Developmental Disabilities
Katarzyna Jarząbek
Affiliation:
Medical University of Bialystok
Sonia Palminiello
Affiliation:
IRCSS San Raffaele Pisana
Marius Walus
Affiliation:
Institute for Basic Research in Developmental Disabilities
Ausma Rabe
Affiliation:
Institute for Basic Research in Developmental Disabilities
Giorgio Albertini
Affiliation:
IRCSS San Raffaele Pisana
Elizabeth Kida
Affiliation:
Institute for Basic Research in Developmental Disabilities
Jean-Adolphe Rondal
Affiliation:
Université de Liège, Belgium
Juan Perera
Affiliation:
Universitat de les Illes Balears, Palma de Mallorca
Donna Spiker
Affiliation:
Stanford Research Institute International
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Summary

The concept of neuronal plasticity and enriched environment

With an occurrence of ~1 in 800 live births, Down syndrome (DS), a chromosome 21 (HSA21) trisomy, is the most common genetic cause of mental retardation (Epstein, 1986). Although the somatic phenotype of DS affects nearly every organ in the body, the predominant and most consistent feature of DS is subnormal intellectual functioning, ranging from mild to severe (Chapman & Hesketh, 2000), resulting from abnormal cognitive and language development, learning and memory impairments, and significant behavioral alterations (Pennington et al., 2003). Underlying the complex neurological phenotype of DS are a number of different central nervous system abnormalities such as hypocellularity (already observed in the fetus), delayed myelination, altered cortical lamination, dendritic and synaptic alterations, and abnormal neurogenesis (Wisniewski et al., 2006). Despite enormous scientific efforts, the cause of the subnormal intellectual functioning of DS patients on the molecular level remains unanswered. It is also unknown whether, which, and to what extent the developmental abnormalities caused by the triplicated chromosome 21 can be mitigated by environmental factors and behavioral therapies (Guralnick, 2005).

Although sophisticated genetic and epigenetic programs predetermine the structural integrity and basal functionality of the mammalian brain at the time of birth, further brain development and refinement of neuronal circuitry are determined through interaction with the surrounding environment. Only with the development of the concepts of neuronal (brain) plasticity and enriched environment has it been possible to more rigorously study the effect of environment on the development and functioning of the mammalian brain in adulthood, under normal and various pathological conditions, both genetic and acquired.

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Type
Chapter
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Neurocognitive Rehabilitation of Down Syndrome
Early Years
 , pp. 71 - 84
Publisher: Cambridge University Press
Print publication year: 2011

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References

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