Skip to main content Accessibility help
×
Hostname: page-component-cb9f654ff-hn9fh Total loading time: 0 Render date: 2025-08-07T07:11:58.959Z Has data issue: false hasContentIssue false

Chapter 28 - Controversy: ablative surgery vs deep-brain stimulation in the management of Parkinson's disease

from Section IV - Clinical Trials in Parkinson's Diease: Lessons, Controversies and Challenges

Published online by Cambridge University Press:  05 March 2016

Néstor Gálvez-Jiménez
Affiliation:
Cleveland Clinic, Florida
Hubert H. Fernandez
Affiliation:
Cleveland Clinic, Ohio
Alberto J. Espay
Affiliation:
University of Cincinnati
Susan H. Fox
Affiliation:
Toronto Western Hospital
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Information

Type
Chapter
Information
Parkinson's Disease
Current and Future Therapeutics and Clinical Trials
, pp. 297 - 312
Publisher: Cambridge University Press
Print publication year: 2016

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Book purchase

Temporarily unavailable

References

Horsley, V. The Linacre Lecture on the function of the so-called motor area of the brain: delivered to the master and fellows of St. John's College, Cambridge, May 6th, 1909. Br Med J 1909; 2: 12132.CrossRefGoogle Scholar
Spiegel, EA, Wycis, HT, Marks, M, Lee, AJ. Stereotaxic apparatus for operations on the human brain. Science 1947; 106: 34950.CrossRefGoogle ScholarPubMed
Spiegel, EA, Wycis, HT, Baird, HW 3rd. Long-range effects of electropallidoansotomy in extrapyramidal and convulsive disorders. Neurology 1958; 8: 73440.CrossRefGoogle ScholarPubMed
Meyers, R. Surgical experiments in the therapy of certain ‘extrapyramidal’ diseases: a current evaluation. Acta Psychiatr Neurol Suppl 1951; 67: 142.Google ScholarPubMed
Cooper, IS. Ligation of the anterior choroidal artery for involuntary movements; parkinsonism. Psychiatr Q 1953; 27: 31719.CrossRefGoogle ScholarPubMed
Cooper, IS. Surgical alleviation of parkinsonism; effects of occlusion of the anterior choroidal artery. J Am Geriatr Soc. 1954; 2: 691718.CrossRefGoogle ScholarPubMed
Guiot, G, Brion, S. Treatment of abnormal movement by pallidal coagulation. Rev Neurol (Paris) 1953; 89: 57880.Google ScholarPubMed
Narabayashi, H, Okuma, T. Procaine oil blocking of the globus pallidus for treatment of rigidity and tremor of parkinsonism: preliminary report. Proc Jpn Acad; 1953; 2 Procaine oil blocking 9: 134.Google Scholar
Hassler, R. The influence of stimulations and coagulations in the human thalamus on the tremor at rest and its physiopathologic mechanism. Proc Second Int Cong Neuropathol 1955; 2: 63742.Google Scholar
Laitinen, LV. Brain targets in surgery for Parkinson's disease. Results of a survey of neurosurgeons. J Neurosurg 1985; 62: 34951.CrossRefGoogle Scholar
Svennilson, E, Torvik, A, Lowe, R, Leksell, L. Treatment of parkinsonism by stereotatic thermolesions in the pallidal region. A clinical evaluation of 81 cases. Acta Psychiatr Scand 1960; 35: 35877.CrossRefGoogle ScholarPubMed
Yahr, MD. Clinical aspects of abnormal movements induced by L-dopa. In: Barbeau, A, McDowell, FH, eds. L-Dopa and Parkinsonism. Davis Company; 1970; 1018.Google Scholar
Barbeau, A. The clinical physiology of side effects in long-term l-DOPA therapy. Adv Neurol 1974; 5: 34765.Google ScholarPubMed
Laitinen, LV, Bergenheim, AT, Hariz, MI. Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. J Neurosurg 1992; 76: 5361.CrossRefGoogle ScholarPubMed
Benabid, AL, Pollak, P, Louveau, A, Henry, S, de Rougemont, J. Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol 1987; 50: 3446.Google ScholarPubMed
Albin, RL, Young, AB, Penney, JB. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989; 12: 36675.CrossRefGoogle ScholarPubMed
Bergman, H, Wichmann, T, DeLong, MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 1990; 249: 14368.CrossRefGoogle ScholarPubMed
Pollak, P, Benabid, AL, Gross, C, et al. Effects of the stimulation of the subthalamic nucleus in Parkinson disease. Rev Neurol (Paris) 1993; 149: 1756.Google ScholarPubMed
Limousin, P, Krack, P, Pollak, P, et al. Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 1998; 339: 110511.CrossRefGoogle ScholarPubMed
Siegfried, J, Lippitz, B. Bilateral chronic electrostimulation of ventroposterolateral pallidum: a new therapeutic approach for alleviating all parkinsonian symptoms. Neurosurgery 1994; 35: 11269; discussion 1129–30.CrossRefGoogle ScholarPubMed
Vitek, JL, Bakay, RA, Hashimoto, T, et al. Microelectrode-guided pallidotomy: technical approach and its application in medically intractable Parkinson's disease. J Neurosurg 1998; 88: 102743.CrossRefGoogle ScholarPubMed
Kaplitt, MG, Hutchison, WD, Lozano, AM. Target localization in movement disorders surgery. In: Tarsy, D, Vitek, JL, Lozano, AM, eds. Surgical Treatment of Parkinson's Disease. Humana Press; 2003; 8798.Google Scholar
Schuurman, PR, Bosch, DA, Merkus, MP, Speelman, JD. Long-term follow-up of thalamic stimulation versus thalamotomy for tremor suppression. Mov Disord 2008; 23: 114653.CrossRefGoogle ScholarPubMed
Loher, TJ, Pohle, T, Krauss, JK. Functional stereotactic surgery for treatment of cervical dystonia: review of the experience from the lesional era. Stereotact Funct Neurosurg 2004; 82: 113.CrossRefGoogle ScholarPubMed
Krayenbuhl, H, Wyss, OA, Yasargil, MG. Bilateral thalamotomy and pallidotomy as treatment for bilateral parkinsonism. J Neurosurg 1961; 18: 42944.CrossRefGoogle ScholarPubMed
Moriyama, E, Beck, H, Miyamoto, T. Long-term results of ventrolateral thalamotomy for patients with Parkinson's disease. Neurol Med Chir (Tokyo) 1999; 39: 3506; discussion 356–7.CrossRefGoogle ScholarPubMed
Jankovic, J, Cardoso, F, Grossman, RG, Hamilton, WJ. Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor. Neurosurgery 1995; 37: 6806; discussion 686–7.CrossRefGoogle ScholarPubMed
Wester, K, Hauglie-Hanssen, E. Stereotaxic thalamotomy – experiences from the levodopa era. J Neurol Neurosurg Psychiatry 1990; 53: 42730.CrossRefGoogle ScholarPubMed
Hallett, M, Litvan, I. Evaluation of surgery for Parkinson's disease: a report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. The Task Force on Surgery for Parkinson's Disease. Neurology 1999; 53: 191021.CrossRefGoogle Scholar
Blomstedt, P, Hariz, GM, Hariz, MI. Pallidotomy versus pallidal stimulation. Parkinsonism Relat Disord 2006; 12: 296301.CrossRefGoogle ScholarPubMed
de Bie, RM, de Haan, RJ, Nijssen, PC, et al. Unilateral pallidotomy in Parkinson's disease: a randomised, single-blind, multicentre trial. Lancet 1999; 354: 16659.CrossRefGoogle ScholarPubMed
Vitek, JL, Bakay, RA, Freeman, A, et al. Randomized trial of pallidotomy versus medical therapy for Parkinson's disease. Ann Neurol 2003; 53: 55869.CrossRefGoogle ScholarPubMed
Kondziolka, D, Bonaroti, E, Baser, S, et al. Outcomes after stereotactically guided pallidotomy for advanced Parkinson's disease. J Neurosurg 1999; 90: 197202.CrossRefGoogle ScholarPubMed
Giller, CA, Dewey, RB, Ginsburg, MI, Mendelsohn, DB, Berk, AM. Stereotactic pallidotomy and thalamotomy using individual variations of anatomic landmarks for localization. Neurosurgery 1998; 42: 5662; discussion 62–5.CrossRefGoogle ScholarPubMed
Shannon, KM, Penn, RD, Kroin, JS, et al. Stereotactic pallidotomy for the treatment of Parkinson's disease. Efficacy and adverse effects at 6 months in 26 patients. Neurology 1998; 50: 4348.CrossRefGoogle ScholarPubMed
Kishore, A, Turnbull, IM, Snow, BJ, et al. Efficacy, stability and predictors of outcome of pallidotomy for Parkinson's disease. six-month follow-up with additional 1-year observations. Brain 1997; 120: 72937.CrossRefGoogle ScholarPubMed
Krauss, JK, Desaloms, JM, Lai, EC, et al. Microelectrode-guided posteroventral pallidotomy for treatment of Parkinson's disease: postoperative magnetic resonance imaging analysis. J Neurosurg 1997; 87: 35867.CrossRefGoogle ScholarPubMed
Lang, AE, Lozano, AM, Montgomery, E, et al. Posteroventral medial pallidotomy in advanced Parkinson's disease. N Engl J Med 1997; 337: 103642.CrossRefGoogle ScholarPubMed
Kazumata, K, Antonini, A, Dhawan, V, et al. Preoperative indicators of clinical outcome following stereotaxic pallidotomy. Neurology 1997; 49: 108390.CrossRefGoogle ScholarPubMed
Uitti, RJ, Wharen, RE Jr, Turk, MF, et al. Unilateral pallidotomy for Parkinson's disease: comparison of outcome in younger versus elderly patients. Neurology 1997; 49: 10727.CrossRefGoogle ScholarPubMed
Trepanier, LL, Saint-Cyr, JA, Lozano, AM, Lang, AE. Neuropsychological consequences of posteroventral pallidotomy for the treatment of Parkinson's disease. Neurology 1998; 51: 20715.CrossRefGoogle ScholarPubMed
Blomstedt, P, Hariz, MI. Are complications less common in deep brain stimulation than in ablative procedures for movement disorders? Stereotact Funct Neurosurg 2006; 84: 7281.CrossRefGoogle ScholarPubMed
Alkhani, A, Lozano, AM. Pallidotomy for Parkinson disease: a review of contemporary literature. J Neurosurg 2001; 94: 439.CrossRefGoogle ScholarPubMed
Perrine, K, Dogali, M, Fazzini, E, et al. Cognitive functioning after pallidotomy for refractory Parkinson's disease. J Neurol Neurosurg Psychiatry 1998; 65: 1504.CrossRefGoogle ScholarPubMed
Biousse, V, Newman, NJ, Carroll, C, et al. Visual fields in patients with posterior GPi pallidotomy. Neurology 1998; 50: 25865.CrossRefGoogle ScholarPubMed
Hariz, MI, De Salles, AA. The side-effects and complications of posteroventral pallidotomy. Acta Neurochir Suppl 1997; 68: 428.Google ScholarPubMed
Zahodne, LB, Okun, MS, Foote, KD, et al. Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus. J Neurol 2009; 256: 13219.CrossRefGoogle ScholarPubMed
Rodrigues, JP, Walters, SE, Watson, P, Stell, R, Mastaglia, FL. Globus pallidus stimulation improves both motor and nonmotor aspects of quality of life in advanced Parkinson's disease. Mov Disord 2007; 22: 186670.CrossRefGoogle ScholarPubMed
Germano, IM, Gracies, JM, Weisz, DJ, et al. Unilateral stimulation of the subthalamic nucleus in Parkinson disease: a double-blind 12-month evaluation study. J Neurosurg 2004; 101: 3642.CrossRefGoogle ScholarPubMed
Mikos, A, Zahodne, L, Okun, MS, Foote, K, Bowers, D. Cognitive declines after unilateral deep brain stimulation surgery in Parkinson's disease: a controlled study using reliable change, part II. Clin Neuropsychol 2010; 24: 23545.CrossRefGoogle ScholarPubMed
Okun, MS, Fernandez, HH, Wu, SS, et al. Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial. Ann Neurol 2009; 65: 58695.CrossRefGoogle ScholarPubMed
Scott, R, Gregory, R, Hines, N, et al. Neuropsychological, neurological and functional outcome following pallidotomy for Parkinson's disease. A consecutive series of eight simultaneous bilateral and twelve unilateral procedures. Brain 1998; 121: 65975.CrossRefGoogle ScholarPubMed
Intemann, PM, Masterman, D, Subramanian, I, et al. Staged bilateral pallidotomy for treatment of Parkinson disease. J Neurosurg 2001; 94: 43744.CrossRefGoogle ScholarPubMed
Counihan, TJ, Shinobu, LA, Eskandar, EN, Cosgrove, GR, Penney, JB Jr. Outcomes following staged bilateral pallidotomy in advanced Parkinson's disease. Neurology 2001; 56: 799802.CrossRefGoogle ScholarPubMed
Iacono, RP, Lonser, RR, Yamada, S. Contemporaneous bilateral postero-ventral pallidotomy for early onset “juvenile type” Parkinson's disease. Case report. Acta Neurochir (Wien) 1994; 131: 24752.CrossRefGoogle Scholar
Iacono, RP, Shima, F, Lonser, RR, et al. The results, indications, and physiology of posteroventral pallidotomy for patients with Parkinson's disease. Neurosurgery 1995; 36: 111825; discussion 1125–7.CrossRefGoogle ScholarPubMed
Vitek, JL, Bakay, RA, DeLong, MR. Microelectrode-guided pallidotomy for medically intractable Parkinson's disease. Adv Neurol 1997; 74: 18398.Google ScholarPubMed
Favre, J, Burchiel, KJ, Taha, JM, Hammerstad, J. Outcome of unilateral and bilateral pallidotomy for Parkinson's disease: patient assessment. Neurosurgery 2000; 46: 34453; discussion 353–5.CrossRefGoogle ScholarPubMed
Siegel, KL, Metman, LV. Effects of bilateral posteroventral pallidotomy on gait of subjects with Parkinson disease. Arch Neurol 2000; 57: 198204.CrossRefGoogle ScholarPubMed
de Bie, RM, Schuurman, PR, Esselink, RA, Bosch, DA, Speelman, JD. Bilateral pallidotomy in Parkinson's disease: a retrospective study. Mov Disord 2002; 17: 5338.CrossRefGoogle ScholarPubMed
Hua, Z, Guodong, G, Qinchuan, L, et al. Analysis of complications of radiofrequency pallidotomy. Neurosurgery 2003; 52: 8999; discussion 99–101.Google ScholarPubMed
York, MK, Lai, EC, Jankovic, J, et al. Short and long-term motor and cognitive outcome of staged bilateral pallidotomy: a retrospective analysis. Acta Neurochir (Wien) 2007; 149: 85766; discussion 866.CrossRefGoogle Scholar
Movement Disorder Society Task Force. Management of Parkinson's disease: an evidence-based review. Mov Disord 2002; 17 (Suppl. 4): S1166.Google Scholar
Merello, M, Starkstein, S, Nouzeilles, MI, Kuzis, G, Leiguarda, R. Bilateral pallidotomy for treatment of Parkinson's disease induced corticobulbar syndrome and psychic akinesia avoidable by globus pallidus lesion combined with contralateral stimulation. J Neurol Neurosurg Psychiatry 2001; 71: 61114.CrossRefGoogle ScholarPubMed
Parkin, SG, Gregory, RP, Scott, R, et al. Unilateral and bilateral pallidotomy for idiopathic Parkinson's disease: a case series of 115 patients. Mov Disord 2002; 17: 68292.CrossRefGoogle ScholarPubMed
de Bie, RM, Schuurman, PR, Esselink, RA, Bosch, DA, Speelman, JD. Bilateral pallidotomy in Parkinson's disease: a retrospective study. Mov Disord 2002; 17: 5338.CrossRefGoogle ScholarPubMed
de Bie, RM, de Haan, RJ, Schuurman, PR, et al. Morbidity and mortality following pallidotomy in Parkinson's disease: a systematic review. Neurology 2002; 58: 100812.CrossRefGoogle ScholarPubMed
Deep-Brain Stimulation for Parkinson's Disease Study Group. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med 2001; 345: 95663.CrossRefGoogle Scholar
Anderson, VC, Burchiel, KJ, Hogarth, P, Favre, J, Hammerstad, JP. Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease. Arch Neurol 2005; 62: 55460.CrossRefGoogle ScholarPubMed
Follett, KA, Weaver, FM, Stern, M, et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. N Engl J Med 2010; 362: 207791.CrossRefGoogle ScholarPubMed
Odekerken, VJ, van Laar, T, Staal, MJ, et al. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial. Lancet Neurol 2013; 12: 3744.CrossRefGoogle ScholarPubMed
Coban, A, Hanagasi, HA, Karamursel, S, Barlas, O. Comparison of unilateral pallidotomy and subthalamotomy findings in advanced idiopathic Parkinson's disease. Br J Neurosurg 2009; 23: 239.CrossRefGoogle ScholarPubMed
Alvarez, L, Macias, R, Pavon, N, et al. Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: results in 89 patients followed for up to 36 months. J Neurol Neurosurg Psychiatry 2009; 80: 97985.CrossRefGoogle ScholarPubMed
Slowinski, JL, Putzke, JD, Uitti, RJ, et al. Unilateral deep brain stimulation of the subthalamic nucleus for Parkinson disease. J Neurosurg 2007; 106: 62632.CrossRefGoogle ScholarPubMed
Linazasoro, G, Van Blercom, N, Lasa, A. Unilateral subthalamic deep brain stimulation in advanced Parkinson's disease. Mov Disord 2003; 18: 71316.CrossRefGoogle ScholarPubMed
Merello, M, Tenca, E, Perez Lloret, S, et al. Prospective randomized 1-year follow-up comparison of bilateral subthalamotomy versus bilateral subthalamic stimulation and the combination of both in Parkinson's disease patients: a pilot study. Br J Neurosurg 2008; 22: 41522.CrossRefGoogle ScholarPubMed
Alvarez, L, Macias, R, Lopez, G, et al. Bilateral subthalamotomy in Parkinson's disease: initial and long-term response. Brain 2005; 128: 57083.CrossRefGoogle ScholarPubMed
Deuschl, G, Schade-Brittinger, C, Krack, P, et al. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med 2006; 355: 896908.CrossRefGoogle ScholarPubMed
Schupbach, WM, Maltete, D, Houeto, JL, et al. Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial. Neurology 2007; 68: 26771.CrossRefGoogle Scholar
Williams, A, Gill, S, Varma, T, et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial. Lancet Neurol 2010; 9: 58191.CrossRefGoogle Scholar
Krack, P, Batir, A, Van Blercom, N, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 2003; 349: 192534.CrossRefGoogle ScholarPubMed
Weaver, FM, Follett, K, Stern, M, et al. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA 2009; 301: 6373.CrossRefGoogle ScholarPubMed
Witt, K, Daniels, C, Reiff, J, et al. Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study. Lancet Neurol 2008; 7: 60514.CrossRefGoogle ScholarPubMed
Esselink, RA, de Bie, RM, de Haan, RJ, et al. Long-term superiority of subthalamic nucleus stimulation over pallidotomy in Parkinson disease. Neurology 2009; 73: 1513.CrossRefGoogle ScholarPubMed
Drapier, D, Drapier, S, Sauleau, P, et al. Does subthalamic nucleus stimulation induce apathy in Parkinson's disease? J Neurol 2006; 253: 108391.CrossRefGoogle ScholarPubMed
Lim, SY, O'sullivan, SS, Kotschet, K, et al. Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson's disease. J Clin Neurosci 2009; 16: 114852.CrossRefGoogle ScholarPubMed
Voon, V, Krack, P, Lang, AE, et al. A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease. Brain 2008; 131: 27208.CrossRefGoogle ScholarPubMed
Bakay, RA, DeLong, MR, Vitek, JL. Posteroventral pallidotomy for Parkinson's disease. J Neurosurg 1992; 77: 4878.Google ScholarPubMed
Van Buren, JM, Li, CL, Shapiro, DY, Henderson, WG, Sadowsky, DA. A qualitative and quantitative evaluation of parkinsonians three to six years following thalamotomy. Confin Neurol 1973; 35: 20235.CrossRefGoogle ScholarPubMed
Fox, SH, Katzenschlager, R, Lim, SY, et al. The Movement Disorder Society Evidence-based Medicine Review Update: treatments for the motor symptoms of Parkinson's disease. Mov Disord 2011; 26 (Suppl. 3): S241.CrossRefGoogle ScholarPubMed
Hooper, AK, Okun, MS, Foote, KD, et al. Clinical cases where lesion therapy was chosen over deep brain stimulation. Stereotact Funct Neurosurg 2008; 86: 14752.CrossRefGoogle ScholarPubMed
Elias, WJ, Huss, D, Voss, T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med 2013; 369: 6408.CrossRefGoogle ScholarPubMed

Accessibility standard: Unknown

Accessibility compliance for the PDF of this book is currently unknown and may be updated in the future.

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×