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Published online by Cambridge University Press: 05 July 2014
The following statements relating to pregnancy in a 38-year-old woman are correct:
1. Her risk of having a child with a neural tube defect is ten times greater than at the age of 18 years.
2. Chorionic villus sampling will allow the diagnosis of a neural tube defect.
3. Her risk of having a child with Down syndrome is less than I%.
Down syndrome
4. has an incidence in the United Kingdom of approximately one in 700 live births.
5. is more commonly due to translocation than to non-dysjunction.
The following disorders are correctly associated with the mode of inheritance:
6. glucose-6-phosphate dehydrogenase deficiency : X-linked recessive.
7. polycystic disease of the kidneys (adult form) : multifactorial.
8. von Willebrand's disease : autosomal dominant.
Methods of value to distinguish the fetus with intrauterine growth restriction from that of uncertain gestational age include
9. increasing ratio of head to abdominal circumference measured by ultrasound.
10. measurement of fetal breathing activity.
11. a single ultrasonic measurement of the biparietal diameter at 37 weeks.
Recognised causes of non-immune hydrops fetalis include
12. alpha-thalassaemia.
13. renal agenesis.
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