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19 - Congenital malformations of the breast

from Part III - Thorax

Published online by Cambridge University Press:  08 January 2010

By
Younghoon R. Cho  and
Arun K. Gosain
Edited by
Mark D. Stringer ,
Keith T. Oldham  and
Pierre D. E. Mouriquand
Younghoon R. Cho
Affiliation:
Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
Arun K. Gosain
Affiliation:
Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
Mark D. Stringer
Affiliation:
University of Otago, New Zealand
Keith T. Oldham
Affiliation:
Children's Hospital of Wisconsin
Pierre D. E. Mouriquand
Affiliation:
Debrousse Hospital, Lyon
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Summary

Introduction

The mammary glands begin their development early in organogenesis and progress through several developmental stages, both in the uterus and in subsequent life. From a biologic standpoint, the mammary glands serve as a source of nourishment and provide passive immunity to our offspring. From a social perspective, mammary glands serve as a means of nurturing these bonds between mother and infant. In addition, they play an important role in defining femininity and our perceptions of beauty and attraction.

The importance of normal breast development can be demonstrated further by the psychosocial impact that results when normal development is interrupted. Congenital breast malformations may become manifest at different stages of breast development. These can be characterized in terms of symmetry, shape variations, over- or underdevelopment, multiple sites of development, unilateral development, or absence of development. Abnormal breast development may affect either sex. In this chapter, we will discuss normal breast development in more detail as well as some of the more common congenital breast disorders encountered in the pediatric population.

Breast development

The development of the mammary glands is initially identical for both sexes, and is a result of complex interplay of growth factors including TGF-α, TGF-β1, tenascin-C and extracellular matrix proteins such as collagen IV during organogenesis. This interplay begins in the fourth week of gestation, when the human embryo measures between 4.5 and 6 mm.

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Type
Chapter
Information
Pediatric Surgery and Urology
Long-Term Outcomes
 , pp. 242 - 252
Publisher: Cambridge University Press
Print publication year: 2006

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