Pharmacogenetics of Diabetes

doi:10.1017/CBO9781139051194.017

14 - Pharmacogenetics of Diabetes

from II - Therapeutic Areas

Published online by Cambridge University Press: 05 June 2012

Mark C. H. de Groot and

Edited by

David Flockhart and

Russ B. Altman: Affiliation:
Stanford University, California
David Flockhart: Affiliation:
Indiana University
David B. Goldstein: Affiliation:
Duke University, North Carolina

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Summary

Health Impact

Diabetes mellitus has become a major public health epidemic, affecting more than 250 million individuals worldwide in 2008, increasing to 380 million in 2025. Each year 3.8 million deaths are attributable to diabetes. An even greater number die of cardiovascular disease made worse by diabetes-related lipid disorders and hypertension (1).

Type 2 diabetes is much more common than type 1 diabetes, and accounts for approximately 90 percent of all diabetes worldwide (2). Type 1 diabetes is characterized by a lack of production of insulin in the body, whereas type 2 diabetes is due to the body's diminished insulin secretion from pancreatic β-cells and the resistance of tissues to insulin (3).

Information

Type: Chapter
Information: Principles of Pharmacogenetics and Pharmacogenomics , pp. 145 - 153

DOI: https://doi.org/10.1017/CBO9781139051194.017 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2012

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