Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-ttngx Total loading time: 0 Render date: 2024-05-15T16:49:52.688Z Has data issue: false hasContentIssue false

16 - Censoring

Published online by Cambridge University Press:  17 April 2022

Michael P. Fay
Affiliation:
National Institute of Allergy and Infectious Diseases
Erica H. Brittain
Affiliation:
National Institute of Allergy and Infectious Diseases
Get access

Summary

This chapter discusses censored time-to-event data. We review and define right-censored and interval-censored data and common assumptions associated with them, focusing on standard cases when the independent censoring assumption holds. We define the Kaplan–Meier estimator, the nonparametric maximum likelihood estimator (NPMLE) for the survival distribution for right censored data. We describe the beta product confidence procedure which gives pointwise confidence intervals for it, with better coverage than the standard Greenwood intervals. We describe the NPMLE for the survival distribution for interval censored data using the E-M algorithm. We compare the proportional hazards or proportional odds models. For both right- and interval-censored data, we describe the score tests from the proportional hazards or odds models, and show they are different forms of weighted logrank tests. We cover testing the difference in survival distributions at a specific point in time. We discuss issues with interpreting the proportional hazards model causally, showing that a model with individual proportional hazards does not equal the usual population proportional hazards model.

Type
Chapter
Information
Statistical Hypothesis Testing in Context
Reproducibility, Inference, and Science
, pp. 302 - 326
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×