Published online by Cambridge University Press: 06 July 2023
Brain disease caused by purulent clots obstructing venous sinuses in children was the first and, for a long time, the only recorded variant of cerebral venous thrombosis. These early cases were secondary to septic inflammation, either elsewhere in the body (de Haen, 1759) or in the mastoid region (Abercrombie, 1818). In 1829, Tonnellé recorded more clinical and morphological details in a large series of children with cerebral phlebitis. Soon afterwards, Bright and Cruveilhier confirmed and illustrated the attendant changes in brain tissue.
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