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11 - The role of the lateral nucleus of the amygdala in auditory fear conditioning

Published online by Cambridge University Press:  08 August 2009

By
Hugh T. Blair ,
Karim Nader ,
Glenn E. Schafe ,
Elizabeth P. Bauer ,
Sarina M. Rodrigues  and
Joseph E. LeDoux
Edited by
James R. Pomerantz
Hugh T. Blair
Affiliation:
Department of Psycology University of California 1285 Franz Hall Box 951563 Los Angeles, CA 90095-1563
Karim Nader
Affiliation:
Department of Psychology McGill University Canada Stewart Biological Sciences Building Room N8/8, 398-3511 1205 Dr Penfield Avenue Montreal, Quebec, H3 A 1B1
Glenn E. Schafe
Affiliation:
Department of Psychology and Interdisciplinary Neuroscience Program Yale University 2 Hillhouse Avenue New Haven, Connecticut 06511-6814
Elizabeth P. Bauer
Affiliation:
W. M. Keck Foundation Laboratory of Neurobiology Center for Neural Science 6 Washington Place, Room 276 New York University New York, NY 10003
Sarina M. Rodrigues
Affiliation:
W. M. Keck Foundation Laboratory of Neurobiology Center for Neural Science New York University New York, New York 10003
Joseph E. LeDoux
Affiliation:
University Professor; Professor of Neural Science and Psychology Center for Neural Science New York University 4 Washington Place, Room 809 New York, NY 10003
James R. Pomerantz
Affiliation:
Rice University, Houston
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Summary

Introduction

Classical fear conditioning is a form of associative learning in which subjects are trained to express fear responses to a neutral conditioned stimulus (CS) that is paired with an aversive unconditioned stimulus (US). As a result of such pairing, the CS comes to elicit behavioral, autonomic, and endocrine responses that are characteristically expressed in the presence of danger (Blanchard & Blanchard, 1969; Bolles & Fanselow, 1980; Smith et al., 1980). Fear conditioning has emerged as an especially useful behavioral model for investigating the neurobiological mechanisms of learning and memory, because fear memories are rapidly acquired and long-lasting, involve well-defined stimuli and responses, and depend upon similar neural circuits in different vertebrate species (see Davis & Lee, 1998; LeDoux, 2000; Maren, 1999; Rogan et al., 2001).

In this chapter, we review studies that have investigated the role of the amygdala in fear learning. We argue that neural plasticity in the lateral amygdala is critical for storing memories of the association between the CS and US during fear conditioning, and discuss how learning and memory are achieved at the cellular or molecular level. Alternative views of amygdala contributions to fear conditioning are also considered.

The amygdala and fear conditioning

Fear learning depends critically upon the amygdala (Davis & Shi, 2000; Fendt & Fanselow, 1999; LeDoux, 1996, 2000), a cluster of nuclei in the brain's temporal lobe that plays a key role in regulating emotions (Kluver & Bucy, 1939; LeDoux, 1996).

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Topics in Integrative Neuroscience
From Cells to Cognition
 , pp. 299 - 325
Publisher: Cambridge University Press
Print publication year: 2008

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  • The role of the lateral nucleus of the amygdala in auditory fear conditioning
    • By Hugh T. Blair, Department of Psycology University of California 1285 Franz Hall Box 951563 Los Angeles, CA 90095-1563, Karim Nader, Department of Psychology McGill University Canada Stewart Biological Sciences Building Room N8/8, 398-3511 1205 Dr Penfield Avenue Montreal, Quebec, H3 A 1B1, Glenn E. Schafe, Department of Psychology and Interdisciplinary Neuroscience Program Yale University 2 Hillhouse Avenue New Haven, Connecticut 06511-6814, Elizabeth P. Bauer, W. M. Keck Foundation Laboratory of Neurobiology Center for Neural Science 6 Washington Place, Room 276 New York University New York, NY 10003, Sarina M. Rodrigues, W. M. Keck Foundation Laboratory of Neurobiology Center for Neural Science New York University New York, New York 10003, Joseph E. LeDoux, University Professor; Professor of Neural Science and Psychology Center for Neural Science New York University 4 Washington Place, Room 809 New York, NY 10003
  • Edited by James R. Pomerantz, Rice University, Houston
  • Book: Topics in Integrative Neuroscience
  • Online publication: 08 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541681.016
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  • The role of the lateral nucleus of the amygdala in auditory fear conditioning
    • By Hugh T. Blair, Department of Psycology University of California 1285 Franz Hall Box 951563 Los Angeles, CA 90095-1563, Karim Nader, Department of Psychology McGill University Canada Stewart Biological Sciences Building Room N8/8, 398-3511 1205 Dr Penfield Avenue Montreal, Quebec, H3 A 1B1, Glenn E. Schafe, Department of Psychology and Interdisciplinary Neuroscience Program Yale University 2 Hillhouse Avenue New Haven, Connecticut 06511-6814, Elizabeth P. Bauer, W. M. Keck Foundation Laboratory of Neurobiology Center for Neural Science 6 Washington Place, Room 276 New York University New York, NY 10003, Sarina M. Rodrigues, W. M. Keck Foundation Laboratory of Neurobiology Center for Neural Science New York University New York, New York 10003, Joseph E. LeDoux, University Professor; Professor of Neural Science and Psychology Center for Neural Science New York University 4 Washington Place, Room 809 New York, NY 10003
  • Edited by James R. Pomerantz, Rice University, Houston
  • Book: Topics in Integrative Neuroscience
  • Online publication: 08 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541681.016
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • The role of the lateral nucleus of the amygdala in auditory fear conditioning
    • By Hugh T. Blair, Department of Psycology University of California 1285 Franz Hall Box 951563 Los Angeles, CA 90095-1563, Karim Nader, Department of Psychology McGill University Canada Stewart Biological Sciences Building Room N8/8, 398-3511 1205 Dr Penfield Avenue Montreal, Quebec, H3 A 1B1, Glenn E. Schafe, Department of Psychology and Interdisciplinary Neuroscience Program Yale University 2 Hillhouse Avenue New Haven, Connecticut 06511-6814, Elizabeth P. Bauer, W. M. Keck Foundation Laboratory of Neurobiology Center for Neural Science 6 Washington Place, Room 276 New York University New York, NY 10003, Sarina M. Rodrigues, W. M. Keck Foundation Laboratory of Neurobiology Center for Neural Science New York University New York, New York 10003, Joseph E. LeDoux, University Professor; Professor of Neural Science and Psychology Center for Neural Science New York University 4 Washington Place, Room 809 New York, NY 10003
  • Edited by James R. Pomerantz, Rice University, Houston
  • Book: Topics in Integrative Neuroscience
  • Online publication: 08 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541681.016
Available formats
×