While the L-system approach introduced in the previous chapter exhibits potential for topology optimization applications, the modeling power of the turtle graphics interpretation is severely limited due to its reliance on limited parameters and its inability to guarantee the deliberate formation of load paths. Based on these characteristics, this chapter introduces a graph-based interpretation approach known as Spatial Interpretation for the Development of Reconfigurable Structures (SPIDRS) that uses principles of graph theory to allow an edge-constructing agent to introduce deliberate topological modifications. Furthermore, SPIDRS operates using instructions generated by a parametric L-system, which enhances modeling power and affords greater design freedom. This approach can also be extended to consider a three-dimensional structural design domain. It will be demonstrated that this interpretation approach results in configurations comparable to known optimal/ideal solutions as well as those found using conventional topology optimization methods, especially when coupled with a sizing optimization scheme to determine optimal structural member thicknesses.