Immunology of Obsessive-Compulsive and Related Disorders

Antonio L. Teixeira; Natalia P. Rocha; Andrea H. Marques

doi:10.1017/9781108164313.007

6 - Immunology of Obsessive-Compulsive and Related Disorders

from Section 1 - Theoretical Foundations of Obsessive-Compulsive and Related Disorders

Published online by Cambridge University Press: 14 December 2018

Antonio L. Teixeira ,

Natalia P. Rocha and

Andrea H. Marques

Edited by

Leonardo F. Fontenelle and

Murat Yücel

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Leonardo F. Fontenelle: Affiliation:
Federal University of Rio de Janeiro
Murat Yücel: Affiliation:
Monash University, Victoria

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Type: Chapter
Information: A Transdiagnostic Approach to Obsessions, Compulsions and Related Phenomena , pp. 51 - 60

DOI: https://doi.org/10.1017/9781108164313.007 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2019

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References

Swedo, SE, Rapoport, JL, Cheslow, DL, et al. High prevalence of obsessive-compulsive symptoms in patients with Sydenham’s chorea. Am J Psychiatry. 1989;146(2):246–249.Google Scholar

Barbosa, IG, Machado-Vieira, R, Soares, JC, Teixeira, AL. The immunology of bipolar disorder. Neuroimmunomodulation. 2014;21(2–3):117–122.Google Scholar

Khandaker, GM, Dantzer, R, Jones, PB. Immunopsychiatry: important facts. Psychol Med. 2017:1–9.Google Scholar

Olsen Saraiva Camara, N, Lepique, AP, Basso, AS. Lymphocyte differentiation and effector functions. Clin Dev Immunol. 2012;2012:510603.Google Scholar

Ziv, Y, Ron, N, Butovsky, O, et al. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci. 2006;9(2):268–275.Google Scholar

de Miranda, AS, Zhang, CJ, Katsumoto, A, Teixeira, AL. Hippocampal adult neurogenesis: does the immune system matter? J Neurol Sci. 2017;372:482–495.Google Scholar

Teixeira, AL, Rodrigues, DH, Marques, AH, Miguel, EC, Fontenelle, LF. Searching for the immune basis of obsessive-compulsive disorder. Neuroimmunomodulation. 2014;21(2–3):152–158.Google Scholar

Taylor, S. Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies. Mol Psychiatry. 2013;18(7):799–805.Google Scholar

Jia, Y, Qin, HJ, Zhang, JX, Liu, XL, Li, LJ. Association of the tumour necrosis factor-alpha polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis. Clin Exp Dermatol. 2013;38(8):836–844.Google Scholar

Baune, BT, Konrad, C, Grotegerd, D, et al. Tumor necrosis factor gene variation predicts hippocampus volume in healthy individuals. Biol Psychiatry. 2012;72(8):655–662.Google Scholar

Rodriguez, N, Morer, A, Gonzalez-Navarro, EA, et al. Human-leukocyte antigen class II genes in early-onset obsessive-compulsive disorder. World J Biol Psychiatry. 2017:1–7.Google Scholar

Maia, DP, Teixeira, AL, Jr, Quintao Cunningham, MC, Cardoso, F. Obsessive compulsive behavior, hyperactivity, and attention deficit disorder in Sydenham chorea. Neurology. 2005;64(10):1799–1801.Google Scholar

Hounie, AG, Pauls, DL, do Rosario-Campos, MC, et al. Obsessive-compulsive spectrum disorders and rheumatic fever: a family study. Biol Psychiatry. 2007;61(3):266–272.Google Scholar

Seixas, AA, Hounie, AG, Fossaluza, V, et al. Anxiety disorders and rheumatic fever: is there an association? CNS Spectr. 2008;13(12):1039–1046.Google Scholar

Ramasawmy, R, Fae, KC, Spina, G, et al. Association of polymorphisms within the promoter region of the tumor necrosis factor-alpha with clinical outcomes of rheumatic fever. Mol Immunol. 2007;44(8):1873–1878.Google Scholar

Hounie, AG, Cappi, C, Cordeiro, Q, et al. TNF-alpha polymorphisms are associated with obsessive-compulsive disorder. Neurosci Lett. 2008;442(2):86–90.Google Scholar

Swedo, SE, Leonard, HL, Rapoport, JL. The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction. Pediatrics. 2004;113(4):907–911.Google Scholar

Snider, LA, Sachdev, V, Mackaronis, JE, St Peter, M, Swedo, SE. Echocardiographic findings in the PANDAS subgroup. Pediatrics. 2004;114(6): e748–e751.Google Scholar

Singer, HS, Hong, JJ, Yoon, DY, Williams, PN. Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. Neurology. 2005;65(11):1701–1707.Google Scholar

Brilot, F, Merheb, V, Ding, A, Murphy, T, Dale, RC. Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome. Neurology. 2011;76(17):1508–1513.Google Scholar

Morris, CM, Pardo-Villamizar, C, Gause, CD, Singer, HS. Serum autoantibodies measured by immunofluorescence confirm a failure to differentiate PANDAS and Tourette syndrome from controls. J Neurol Sci. 2009;276(1–2):45–48.Google Scholar

Kurlan, R, Johnson, D, Kaplan, EL. Tourette Syndrome Study G. Streptococcal infection and exacerbations of childhood tics and obsessive-compulsive symptoms: a prospective blinded cohort study. Pediatrics. 2008;121(6):1188–1197.Google Scholar

Leckman, JF, King, RA, Gilbert, DL, et al. Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study. J Am Acad Child Adolesc Psychiatry. 2011;50(2):108–118.e3.Google Scholar

Singer, HS, Gilbert, DL, Wolf, DS, Mink, JW, Kurlan, R. Moving from PANDAS to CANS. J Pediatr. 2012;160(5):725–731.Google Scholar

Williams, KA, Swedo, SE, Farmer, CA, et al. Randomized, controlled trial of intravenous immunoglobulin for pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Am Acad Child Adolesc Psychiatry. 2016;55(10):860–867.e2.Google Scholar

Swedo, SE, Seidlitz, J, Kovacevic, M, et al. Clinical presentation of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections in research and community settings. J Child Adolesc Psychopharmacol. 2015;25(1):26–30.Google Scholar

Chang, K, Frankovich, J, Cooperstock, M, et al. Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference. J Child Adolesc Psychopharmacol. 2015;25(1):3–13.Google Scholar

de Barros, JL, Barbosa, IG, Salem, H, et al. Is there any association between Toxoplasma gondii infection and bipolar disorder? A systematic review and meta-analysis. J Affect Disord. 2017;209:59–65.Google Scholar

Miman, O, Mutlu, EA, Ozcan, O, Atambay, M, Karlidag, R, Unal, S. Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder? Psychiatry Res. 2010;177(1–2):263–265.Google Scholar

Flegr, J, Horacek, J. Toxoplasma-infected subjects report an obsessive-compulsive disorder diagnosis more often and score higher in obsessive-compulsive inventory. Eur Psychiatry. 2017;40:82–87.Google Scholar

Perez-Vigil, A, Fernandez de la Cruz, L, Brander, G, Isomura, K, Gromark, C, Mataix-Cols, D. The link between autoimmune diseases and obsessive-compulsive and tic disorders: a systematic review. Neurosci Biobehav Rev. 2016;71:542–562.Google Scholar

Gray, SM, Bloch, MH. Systematic review of proinflammatory cytokines in obsessive-compulsive disorder. Curr Psychiatry Rep. 2012;14(3):220–228.Google Scholar

Simsek, S, Yuksel, T, Cim, A, Kaya, S. Serum cytokine profiles of children with obsessive-compulsive disorder shows the evidence of autoimmunity. Int J Neuropsychopharmacol. 2016;19(8):pii: pyw027.Google Scholar

Mitchell, RH, Goldstein, BI. Inflammation in children and adolescents with neuropsychiatric disorders: a systematic review. J Am Acad Child Adolesc Psychiatry. 2014;53(3):274–296.Google Scholar

Fontenelle, LF, Barbosa, IG, Luna, JV, de Sousa, LP, Abreu, MN, Teixeira, AL. A cytokine study of adult patients with obsessive-compulsive disorder. Compr Psychiatry. 2012;53(6):797–804.Google Scholar

Carpenter, LL, Heninger, GR, McDougle, CJ, Tyrka, AR, Epperson, CN, Price, LH. Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Psychiatry Res. 2002;112(3):257–262.Google Scholar

Mittleman, BB, Castellanos, FX, Jacobsen, LK, Rapoport, JL, Swedo, SE, Shearer, GM. Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease. J Immunol. 1997;159(6):2994–2999.Google Scholar

Marazziti, D, Presta, S, Pfanner, C, et al. Immunological alterations in adult obsessive-compulsive disorder. Biol Psychiatry. 1999;46(6):810–814.Google Scholar

Marazziti, D, Mungai, F, Masala, I, et al. Normalisation of immune cell imbalance after pharmacological treatments of patients suffering from obsessive-compulsive disorder. J Psychopharmacol. 2009;23(5):567–573.Google Scholar

da Rocha, FF, Correa, H, Teixeira, AL. Obsessive-compulsive disorder and immunology: a review. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(5):1139–1146.Google Scholar

Maina, G, Albert, U, Bogetto, F, et al. Anti-brain antibodies in adult patients with obsessive-compulsive disorder. J Affect Disord. 2009;116(3):192–200.Google Scholar

Nicholson, TR, Ferdinando, S, Krishnaiah, RB, et al. Prevalence of anti-basal ganglia antibodies in adult obsessive-compulsive disorder: cross-sectional study. Br J Psychiatry. 2012;200(5):381–386.Google Scholar

Pearlman, DM, Vora, HS, Marquis, BG, Najjar, S, Dudley, LA. Anti-basal ganglia antibodies in primary obsessive-compulsive disorder: systematic review and meta-analysis. Br J Psychiatry. 2014;205(1):8–16.Google Scholar

Bhattacharyya, S, Khanna, S, Chakrabarty, K, Mahadevan, A, Christopher, R, Shankar, SK. Anti-brain autoantibodies and altered excitatory neurotransmitters in obsessive-compulsive disorder. Neuropsychopharmacology. 2009;34(12):2489–2496.Google Scholar

Frick, L, Pittenger, C. Microglial dysregulation in OCD, Tourette syndrome, and PANDAS. J Immunol Res. 2016;2016:8606057.Google Scholar

Kumar, A, Williams, MT, Chugani, HT. Evaluation of basal ganglia and thalamic inflammation in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection and Tourette syndrome: a positron emission tomographic (PET) study using 11C-[R]-PK11195. J Child Neurol. 2015;30(6):749–756.Google Scholar

Attwells, S, Setiawan, E, Wilson, AA, et al. Inflammation in the neurocircuitry of obsessive-compulsive disorder. JAMA Psychiatry. 2017;74(8):833–840.Google Scholar

Lennington, JB, Coppola, G, Kataoka-Sasaki, Y, et al. Transcriptome analysis of the human striatum in Tourette syndrome. Biol Psychiatry. 2016;79(5):372–382.Google Scholar

Ebrahimi Taj, F, Noorbakhsh, S, Ghavidel Darestani, S, Shirazi, E, Javadinia, S. Group A beta-hemolytic streptococcal infection in children and the resultant neuro-psychiatric disorder; a cross sectional study; Tehran, Iran. Basic Clin Neurosci. 2015;6(1):38–43.Google Scholar

Oglodek, EA, Szota, AM, Just, MJ, Mos, DM, Araszkiewicz, A. The MCP-1, CCL-5 and SDF-1 chemokines as pro-inflammatory markers in generalized anxiety disorder and personality disorders. Pharmacol Rep. 2015;67(1):85–89.Google Scholar

Kawikova, I, Leckman, JF, Kronig, H, et al. Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study. Biol Psychiatry. 2007;61(3):273–278.Google Scholar

Leckman, JF, Katsovich, L, Kawikova, I, et al. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biol Psychiatry. 2005;57(6):667–673.Google Scholar

Gabbay, V, Coffey, BJ, Guttman, LE, et al. A cytokine study in children and adolescents with Tourette’s disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(6):967–971.Google Scholar

Bos-Veneman, NG, Bijzet, J, Limburg, PC, Minderaa, RB, Kallenberg, CG, Hoekstra, PJ. Cytokines and soluble adhesion molecules in children and adolescents with a tic disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(8):1390–1395.Google Scholar

Perlmutter, SJ, Leitman, SF, Garvey, MA, et al. Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood. Lancet. 1999;354(9185):1153–1158.Google Scholar

Murphy, TK, Brennan, EM, Johnco, C, et al. A double-blind randomized placebo-controlled pilot study of azithromycin in youth with acute-onset obsessive-compulsive disorder. J Child Adolesc Psychopharmacol. 2017;27(7):640–651.Google Scholar

Murphy, TK, Parker-Athill, EC, Lewin, AB, Storch, EA, Mutch, PJ. Cefdinir for recent-onset pediatric neuropsychiatric disorders: a pilot randomized trial. J Child Adolesc Psychopharmacol. 2015;25(1):57–64.Google Scholar

Muller, N. Anti-inflammatory therapy with a COX-2 inhibitor in Tourette’s syndrome. Inflammopharmacology. 2004;12(3):271–275.Google Scholar

Brown, K, Farmer, C, Farhadian, B, Hernandez, J, Thienemann, M, Frankovich, J. Pediatric acute-onset neuropsychiatric syndrome response to oral corticosteroid bursts: an observational study of patients in an academic community-based PANS clinic. J Child Adolesc Psychopharmacol. 2017;27(7):629–639.Google Scholar

Barash, J, Margalith, D, Matitiau, A. Corticosteroid treatment in patients with Sydenham’s chorea. Pediatr Neurol. 2005;32(3):205–207.Google Scholar

Paz, JA, Silva, CA, Marques-Dias, MJ. Randomized double-blind study with prednisone in Sydenham’s chorea. Pediatr Neurol. 2006;34(4):264–269.Google Scholar

Walker, AR, Tani, LY, Thompson, JA, Firth, SD, Veasy, LG, Bale, JF, Jr. Rheumatic chorea: relationship to systemic manifestations and response to corticosteroids. J Pediatr. 2007;151(6):679–683.Google Scholar

Brown, KD, Farmer, C, Freeman, GM, Jr, et al. Effect of early and prophylactic nonsteroidal anti-inflammatory drugs on flare duration in pediatric acute-onset neuropsychiatric syndrome: an observational study of patients followed by an academic community-based pediatric acute-onset neuropsychiatric syndrome clinic. J Child Adolesc Psychopharmacol. 2017;27(7):619–628.Google Scholar

Grant, JE. Clinical practice: obsessive-compulsive disorder. N Engl J Med. 2014;371(7):646–653.Google Scholar

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