This chapter traces William Burroughs’ lifelong obsession with disease – particularly cancer and viruses – as a central metaphor in his critique of power, control, and modernity. Polina Mackay and James Mackay argue that Burroughs’ engagement with medicine, from his early syphilis diagnosis to his interest in Wilhelm Reich’s unorthodox theories, shaped his representation of illness as both literal and ideological contagion. From Junky to Naked Lunch, the cut-up texts, and Blade Runner: A Movie, Burroughs portrays medical institutions and bureaucracies not as healing forces but as agents of repression, manipulation, and decay. The chapter shows how Burroughs’ writing fuses Reichian thought, alternative medicine, and paranoid systems theory into a distinctive epidemiology of language, addiction, and social control. While his metaphoric conflation of disease and power reveals the limits of postwar biopolitics, it also risks collapsing critical inquiry into conspiracy. Ultimately, Burroughs’ viral imagination oscillates between incisive cultural diagnosis and reactionary anxiety, offering a vision of medicine as both metaphor and battleground.