The Biological Underpinnings of Depression

doi:10.1017/CBO9780511841262.005

3 - The Biological Underpinnings of Depression

Published online by Cambridge University Press: 05 June 2012

Ania Korszun ,

Margaret Altemus and

Elizabeth A. Young

Edited by

Corey L. M. Keyes and

Sherryl H. Goodman

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Ania Korszun: Affiliation:
Bart's and The London Queen Mary's School of Medicine and Dentistry, London, United Kingdom
Margaret Altemus: Affiliation:
Weill Medical College, Cornell University, Ithaca, New York
Elizabeth A. Young: Affiliation:
Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan
Corey L. M. Keyes: Affiliation:
Emory University, Atlanta
Sherryl H. Goodman: Affiliation:
Emory University, Atlanta

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Summary

INTRODUCTION

Stress and Depression

Depressive disorders are widely regarded as stress-related conditions. Although genetic vulnerability is critical to the development of depression, in the absence of environmental stressors, the incidence of depressive disorders is very low (Kendler et al., 1995), and in approximately 75% of cases of depression there is a precipitating life event (Brown & Harris, 1978; Frank, Anderson, Reynolds, Ritenour, & Kupfer, 1994). Living organisms survive by maintaining a complex dynamic equilibrium or homeostasis that is constantly challenged by intrinsic or extrinsic stressors. These stressors set in motion responses aimed at preserving homeostasis, including activation of a wide variety of neurotransmitters and neuromodulators. The hypothalamic pituitary adrenal (HPA) axis is the body's main stress hormonal system. Corticotropin releasing hormone (CRH) is the principal central effector of the stress response (Chrousos & Gold, 1992). CRH triggers the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary corticotrope, which, in turn, triggers the release of adrenal glucocorticoids. The stress response is terminated by glucocorticoid feedback at brain and pituitary sites.

Depression has been conceptualized as maladaptive, exaggerated responses to stress. Abnormalities of the HPA axis, as manifested by hypercortisolemia and disruption of the circadian rhythm of cortisol secretion, are well established phenomena in depression (Carroll, Curtis, & Mendels, 1976; Sachar et al., 1973).

Type: Chapter
Information: Women and Depression
A Handbook for the Social, Behavioral, and Biomedical Sciences
, pp. 41 - 61

DOI: https://doi.org/10.1017/CBO9780511841262.005 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2006

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References

Ahima, R. S., Lawson, A. N. L., Osei, S. Y. S., & Harlan, R. E. (1992). Sexual dimorphism in regulation of type II corticosteroid receptor immunoreactivity in the rat hippocampus. Endocrinology, 131, 1409–1416CrossRef Google Scholar PubMed

Altemus, M., Pigott, T., Kalogeras, K. T., Demitrack, M., Dubbert, B., Murphy, D. L.. (1992). Abnormalities in the regulation of vasopressin and corticotropin releasing factor secretion in obsessive-compulsive disorder. Archives of General Psychiatry, 49, 9–20CrossRef Google Scholar PubMed

Altemus, M., Redwine, L., Yung-Mei, L., Yoshikawa, T., Yehuda, R., Detera-Wadleigh, S.. (1997). Reduced sensitivity to glucocorticoid feedback and reduced glucocorticoid receptor mRna expression in the luteal phase of the menstrual cycle. Neurosychopharmacology, 17, 100–109Google Scholar PubMed

Altshuler, L. L., Hendrick, V., & Cohen, L. S. (1998). Course of mood and anxiety disorders during pregnancy and the postpartum period. Journal of Clinical Psychiatry, 59 (Suppl 2), 29–33Google Scholar PubMed

Amsterdam, J. C., Winokur, A., Abelman, E., Lucki, I., & Richels, K. (1983). Co-syntropin (ACTH a1–24) stimulation test in depressed patients and healthy subjects. American Journal of Psychiatry, 140, 907–909Google Scholar

Arango, V., Ernsberge, r P., Marzuk, P. M., Chen, J. S., Tierney, H., Stanley, M.. (1990). Autoradiographic demonstration of increased serotonin 5-HT2 and b-adrenergic receptor binding sites in the brain of suicide victims. Archives of General Psychiatry, 47, 1038–1047CrossRef Google Scholar

Arango, V., Underwood, M. D., Boldrini, M., Tamir, H., Kassir, S. A., Hsiung, S.. (2001). Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology, 25, 892–903CrossRef Google Scholar PubMed

Arato, M., Frecska, E., Tekes, K., & MacCrimmon, D. J. (1991). Serotonergic interhemispheric asymmetry: gender difference in the orbital cortex. Acta Psychiatrica Scandinavica, 84, 110–111CrossRef Google Scholar PubMed

Arriza, J. L., Weinberger, C., Cerelli, G., Glaser, T. M., Handelin, B. L., Housman, D. E.. (1987). Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor. Science, 237, 268–275CrossRef Google Scholar PubMed

Asberg, M., Traskman, L., & Thoren, P. (1976) 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor?Archives of General Psychiatry, 33, 1193–1197CrossRef Google Scholar PubMed

Barden, N., Reul, J. M. H. M., & Holsboer, F. (1995). Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?Trends in Neuroscience, 18, 6–10CrossRef Google Scholar PubMed

Baxter, L. R. Jr., Schwartz, J. M., Phelps, M. E., Mazziotta, J. C., Guze, B. H., Selin, C. E.. (1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives General Psychiatry, 46, 243–250CrossRef Google Scholar

Berendsen, H. H. (1995). Interactions between 5-hydroxytryptamine receptor subtypes: is a disturbed receptor balance contributing to the symptomatology of depression in humans?Pharmacology Therapeutics, 66, 17–37CrossRef Google Scholar PubMed

Bhagwagar, Z., Hafizi, S., & Cowen, P. J. (2003). Increase in concentration of waking salivary cortisol in recovered patients with depression. American Journal of Psychiatry, 160, 1890–1891CrossRef Google Scholar PubMed

Biegon, A., & Greuner, N. (1992). Age-related changes in serotonin 5HT2 receptors on human blood platelets. Psychopharmacology, 108, 210–212CrossRef Google Scholar PubMed

Biegon, A., Reches, A., Snyder, L., McEwen, B. S.. (1983). Serotonergic and noradrenergic receptors in the rat brain: modulation by chronic exposure to ovarian hormones. Life Sciences, 32, 2015–21CrossRef Google Scholar PubMed

Bierut, L. J., Heath, A. C., Bucholz, K. K., Dinwiddie, S. H., Madden, P. A. F., Statham, D. J.. (1999). Major depressive disorder in a community-based twin sample: Are there different genetic and environmental contributions for men and women?Archives General Psychiatry, 56, 557–563CrossRef Google Scholar

Biver, F., Lotstra, F., Monclus, M., Wikler, D., Damhaut, P., Mendlewicz, J.. (1996). Sex difference in 5HT2 receptor in the living human brain. Neuroscience Letters, 204, 25–28CrossRef Google Scholar PubMed

Blier, P., & Montigny, C. (1994). Current advances and trends in the treatment of depression. Trends in Pharmacological Sciences, 15, 220–226CrossRef Google Scholar PubMed

Bonson, K. R., Johnson, R. G., Fiorella, D., Rabin, R. A., & Winter, J. C. (1994). Serotonergic control of androgen-induced dominance. Pharmacology, Biochemistry & Behavior, 49, 313–322CrossRef Google Scholar PubMed

Borisova, N. A., Proshlyakova, E. V., Sapronova, A. Y., & Ugrumov, M. V. (1996). Androgen-dependent sex differences in the hypothalamic serotoninergic system. European Journal of Endocrinology, 134, 232–235CrossRef Google Scholar PubMed

Borsini, F. (1994). Balance between cortical 5-HT1A and 5-HT2 receptor function: hypothesis for a faster antidepressant action. Pharmacological Research, 30, 1–11CrossRef Google Scholar PubMed

Brady, L., Whitfield, H. J., Fox, R. J., Gold, P. W., & Herkenham, M. (1991). Long-term antidepressant administration alters corticotropin releasing hormone, tyrosine hydroxylase and mineralocorticoid receptor gene expression in rat brain: Therapeutic implications. Journal of Clinical Investigations, 87, 831–837CrossRef Google Scholar PubMed

Brown, G. W., & Harris, T. (1978). Social origins of depression: A study of psychiatric disorder in women. New York: The Free PressGoogle Scholar

Buchsbaum, M. S., Wu, J., DeLisi, L. E., Holcomb, H., Kessler, R., Johnson, J.. (1986). Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with FDG in affective illness. Journal Affective Disorders, 10, 137–152CrossRef Google Scholar PubMed

Burgess, L. H., & Handa, R. J. (1992). Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats. Endocrinology, 131, 1261–1269CrossRef Google Scholar PubMed

Butler, P. D., & Nemeroff, C. B. (1990). Corticotropin releasing factor as a possible cause of comorbidity in anxiety and depressive disorders. In Maser, J. D. & Cloninger, C. R. (Eds.), Comorbidity of mood and anxiety disorders. Washington, DC: American Psychiatric PressGoogle Scholar

Carey, M. P., Deterd, C. H., Koning, J., Helmerhorst, , & DeKloet, E. R. (1995). The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the femal rat. Journal of Endocrinology, 144, 311–332CrossRef Google Scholar

Carlsson, M., & Carlsson, A. (1988). A regional study in sex differences in rat brain serotonin. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 12, 53–61CrossRef Google Scholar PubMed

Carroll, B. J., Curtis, G. C., & Mendels, J. (1976). Neuroendocrine regulation in depression I. Limbic system-adrenocortical dysfunction. Archives of General Psychiatry, 33, 1039–1044CrossRef Google Scholar PubMed

Carroll, B. J., Feinberg, M., Greden, J. F., Tarika, J., Albala, A. A., Haskett, R. F.. (1981). A specific laboratory test for the diagnosis of melancholia. Archives of General Psychiatry, 38, 15–22CrossRef Google Scholar

Charney, D., Woods, S., Goodman, W., & Heninger, G. (1987). Neurobiological mechanisms of panic anxiety: Biochemical and behavioral correlates of yohimbine-induced panic attacks. American Journal of Psychiatry, 144, 1030–1036Google Scholar PubMed

Chrousos, G. P., & Gold, P. W. (1992). The concepts of stress and stress system disorders: Overview of physical and behavioral homeostasis. Journal of the American Medical Association, 267, 1244–1252CrossRef Google Scholar PubMed

Dean, C., Williams, R. J., & Brockington, I. F. (1989). Is puerperal psychosis the same as bipolar manic-depressive disorder? A family study. Psychological Medicine, 19, 637–647CrossRef Google Scholar PubMed

Drevets, W. C., Frank, E., Price, J. C., Kupfer, D. J., Greer, P. J., & Mathis, C. (2000). Serotonin type-1A receptor imaging in depression. Nuclear Medicine and Biology, 27, 499–507CrossRef Google Scholar PubMed

Drevets, W. C., Frank, E., Price, J. C., Kupfer, D. J., Holt, D., Greer, P. J.. (1999). PET imaging of serotonin 1A receptor binding in depression. Biological Psychiatry, 46, 1375–1387CrossRef Google Scholar PubMed

Drevets, W. C., Videen, T. O., Price, J. L., Preskorn, S. H., Carmichael, S. T., & Raichle, M. E. (1992). A functional anatomical study of unipolar depression. Journal of Neuroscience, 12, 3628–3641CrossRef Google Scholar PubMed

Duncan, M. R., & Duncan, G. R. (1979). An in vivo study of the action of antiglucocorticoids on thymus weight ratio, antibody titre and the adrenal-pituitary-hypothalamus axis. Journal of Steroid Biochemistry, 10, 245–259CrossRef Google Scholar

Ehrenkranz, J. R. (1976). Effects of sex steroids on serotonin uptake in blood platelets. Acta Endocrinologica, 83, 420–428Google Scholar PubMed

Eriksson, E., Hedberg, M. A., Andersch, B., & Sundblad, C. (1995). The serotonin reuptake inhibitor paroxetine is superior to the noradrenaline reuptake inhibitor maprotiline in the treatment of premenstrual syndrome. Neuropsychopharmacology, 12, 167–176CrossRef Google Scholar PubMed

Fink, G., Sumner, B. E., Rosie, R., Grace, O., & Quinn, J. P. (1996). Estrogen control of central neurotransmission: effect on mood, mental state, and memory. Cellular & Molecular Neurobiology, 16, 325–344CrossRef Google Scholar PubMed

Fishette, C. T., Biegon, A., & McEwen, B. S. (1984). Sex steroid modulation of the serotonin behavioral syndrome. Life Sciences, 35, 1197–1206CrossRef Google Scholar

Frank, E., Anderson, B., Reynolds, C., Ritenour, A., & Kupfer, D. J. (1994). Life events and the research diagnostic criteria endogenous subtype: A confirmation of the distinction using the Bedford College methods. Archives of General Psychiatry, 51, 519–524CrossRef Google Scholar PubMed

Galliven, E. A., Singh, A., Michelson, D., Bina, S., Gold, P. W., & Deuster, P. A. (1997). Hormonal and metabolic responses to exercise across time of day and menstrual cycle phase. Journal of Applied Physiology, 6, 1822–1831CrossRef Google Scholar

Gelfin, Y., Lerer, B., Lesch, K. P., Gorfine, M., & Allolio, B. (1995). Complex effects of age and gender on hypothermic, adrenocorticotrophic hormone and cortisol responses to ipsapirone challenge in normal subjects. Psychopharmacology, 120, 356–364CrossRef Google Scholar PubMed

George, M. S., Ketter, T. A., Parekh, P. I., Horwitz, B., Herscovitch, P., & Post, R. M. (1995). Brain activity during transient sadness and happiness in healthy women. American Journal of Psychiatry, 152, 341–351Google Scholar PubMed

George, M. S., Ketter, T. A., & Post, R. M. (1994). Prefrontal cortex dysfunction in clinical depression. Depression, 2, 59–72CrossRef Google Scholar

Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H.. (1986). Response to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease. New England Journal of Medicine, 314, 1329–1335CrossRef Google Scholar

Gregoire, A., Kumar, R., Everitt, B., Henderson, A. F., & Studd, J. W. (1996). Transdermal oestrogen for treatment of severe postnatal depression. Lancet, 347, 930–933CrossRef Google Scholar PubMed

Greist, J. H., Jefferson, J. W., Kobak, K. A., Katzelnick, D. J., & Serlin, R. C. (1995). Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. Archives of General Psychiatry, 52, 53–60CrossRef Google Scholar PubMed

Halbreich, U., Asnis, G. M., Schindledecker, R., Zurnoff, B., & Nathan, R. S. (1985). Cortisol secretion in endogenous depression I. Basal plasma levels. Archives of General Psychiatry, 42, 909–914CrossRef Google Scholar PubMed

Haleem, D. J., Kennett, G. A., & Curzon, G. (1990). Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT. Journal of Neural Transmission, 79, 93–101CrossRef Google Scholar PubMed

Heinsbroek, R. P., Haaren, F., Feenstra, M. G., Galen, H., Boer, G., & Pool, N. E. (1990). Sex differences in the effects of inescapable footshock on central catecholaminergic and serotonergic activity. Pharmacology, Biochemistry & Behavior, 37, 539–550CrossRef Google Scholar PubMed

Heninger, G. R., & Charney, D. S. (1987). Mechanism of action of antidepressant treatment: Implications for the etiology and treatment of depressive disorders. In Meltzer, H. Y. (Ed.), Psychopharmacology: The third generation of progress (pp. 535–544). New York: Raven PressGoogle Scholar

Holsboer, F., Bardeleden, U., Gerken, A., Stalla, G., & Muller, O. (1984). Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression. New England Journal of Medicine, 311, 1127Google Scholar PubMed

Hrdina, P. D., Bakish, D., Chudzik, J., Ravindran, A., & Lapierre, Y. D. (1995). Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. Journal of Psychiatry & Neuroscience, 20, 11–19Google Scholar PubMed

Hrdina, P. D., Demeter, E., Vu, T. B., Sotonyi, P., & Palkovits, M. (1993). 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: Increase in 5-HT2 sites in cortex and amygdala. Brain Research, 614, 37–44CrossRef Google Scholar PubMed

Issa, A. M., Rowe, W., & Meaney, M. J. (1990). Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. Journal of Neuroscience, 10, 3247–3254CrossRef Google Scholar PubMed

Jones, I., Kent, L., & Craddock, N. (2002). Genetics of affective disorders. In McGuffin, P., Owen, M. J., & Gottesman, II (Eds.), Psychatric genetics & genomics (pp. 211–245). Oxford: Oxford University PressGoogle Scholar

Jones, M. T., Brush, F. R., & Neame, R. L. B. (1972). Characteristics of fast feedback control of corticotrophin release by corticosteroids. Journal of Endocrinology, 55, 489CrossRef Google Scholar PubMed

Keller-Wood, M., Silbiger, J., & Wood, C. E. (1988). Progesterone attenuates the inhibition of adrenocorticotropin responses by cortisol in nonpregnant ewes. Endocrinology, 123, 647–651CrossRef Google Scholar PubMed

Kendler, K. S. (1998). Major depression and the environment: A psychiatric genetic perspective. Pharmacopsychiat, 31, 5–9CrossRef Google Scholar PubMed

Kendler, K. S., Gardner, C. O., Neale, M. C., & Prescott, C. A. (2001). Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?Psychological Medicine, 31, 605–616CrossRef Google Scholar PubMed

Kendler, K. S., Kessler, R. C., Walters, E. E., MacLean, C., Neale, M. C., Heath, A. C.. (1995). Stressful life events, genetic liability and onset of an episode of major depression in women. American Journal of Psychiatry, 152, 833–842Google Scholar PubMed

Kendler, K. S., Pedersen, N. L., Neale, M. C., & Mathe, A. A. (1995). A pilot Swedish twin study of affective disorders including hospital- and population-ascertained subsamples: Results of model fitting. Behavioral Genetics, 25, 217–232CrossRef Google Scholar PubMed

Kessler, R. C., McGonagle, K. A., Swartz, M., Blazer, D. G., & Nelson, C. B. (1993). Sex and depression in the National Comorbidity Survey I: Lifetime prevalence, chronicity and recurrence. Journal of Affective Disorders, 29, 85–96CrossRef Google Scholar PubMed

Ketter, T. A., George, M. S., Kimbrell, T. A., & Post, R. M. (1996). Functional brain imaging, limbic function, and affective disorders. Neuroscientist, 2, 55–65CrossRef Google Scholar

Kirschbaum, C., Kudielka, B. M., Gaab, J., Schommer, N. C., & Hellhammer, D. H. (1999). Impact of gender, menstrual cycle phase and oral contraceptives on the hypothalamic-pituitary-adrenal axis. Psychosomatic Medicine, 64, 154–162CrossRef Google Scholar

Kirschbaum, C., Pirke, K-M., & Hellhammer, D. H. (1995). Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication. Psychoneuroendocrinology, 20, 509–514CrossRef Google Scholar PubMed

Kirschbaum, C., Schommer, N., Federenko, I., Gaab, J., Neumann, O., Oellers, M.. (1996). Short-term estradiol treatment enhances pituitary-adrenal axis and sympathetic responses to psychosocial stress in healthy young men. Journal of Clinical Endocrinology and Metabolism, 81, 3639–3643Google Scholar PubMed

Klimek, V., Zak-Knapik, J., & Mackowiak, M. (1994). Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain. Journal Psychiatry and Neuroscience, 19, 63–67Google Scholar PubMed

Komesaroff, P. A., Esler, M., Clarke, I. J., Fullerton, M. J., & Funder, J. W. (1998). Effects of estrogen and estrous cycle on glucocorticoid and catecholamine responses to stress in sheep. American Journal of Physiology, 275, E671–678Google Scholar

Komesaroff, P. A., Esler, M. D., & Sudhir, K. (1999). Estrogen supplementation attenuates glucocorticoid and catecholamine responses to mental stress in perimenopausal women. Journal of Clinical Endocrinology and Metabolism, 84, 606–610Google Scholar PubMed

Krishnan, K. R. R., Ritchie, J. C., Saunders, W. B., Nemeroff, C. B., & Carroll, B. J. (1990). Adrenocortical sensitivity to low-dose ACTH administration in depressed patients. Biological Psychiatry, 27, 930–933CrossRef Google Scholar PubMed

Leckman, J. F., Goodwin, W. K., North, W. G., Cappell, P. B., Price, L. H., Pauls, D. L.. (1994). The role of central oxytocin in obssessive-compulsive disorder and related normal behavior. Psychoneuroendocrinology, 19, 723–749CrossRef Google Scholar

Lerer, B., Gillon, D., Lichtenberg, P., Gorfine, M., Gelfin, Y., & Shapira, B. (1996). Interrelationship of age, depression, and central serotonergic function: evidence from fenfluramine challenge studies. International Psychogeriatrics, 8, 83–102CrossRef Google Scholar PubMed

Linkowski, P., Mendelwicz, J., LeClercq, R., Brasseur, M., Hubain, P., Goldstein, J., Copinschi, G., Cauter, E. (1985). The 24-hour profile of ACTH and cortisol in major depressive illness. Journal of Clinical Endocrinology and Metabolism, 61, 429–438CrossRef Google Scholar PubMed

López, J. F., Vázquez, D. M., Chalmers, D. T., Akil, H., & Watson, S. J. (1997). Regulation of 5-HT receptors and the Hypothalamic-Pituitary-Adrenal axis: Implications for the neurobiology of suicide. Annals of New York Academy of Science, 836, 106–134CrossRef Google Scholar PubMed

Lyons, M. J., Eisen, S. A., Goldberg, J., True, W., Lin, N., Meyer, J. M.. (1998). A registry-based twin study of depression in men. Archives of General Psychiatry, 55, 468–472CrossRef Google Scholar PubMed

Mann, J. J., Arango, V., & Underwood, M. D. (1990). Serotonin and suicidal behavior. Annals of New York Academy Sciences, 600, 476–484CrossRef Google Scholar PubMed

Marcusson, J., Oreland, L., & Winblad, B. (1984). Effect of age on human brain serotonin (S-1) binding sites. Journal of Neurochemistry, 43, 1699–1705CrossRef Google Scholar PubMed

Martinez-Conde, E., Leret, M. L., & Diaz, S. (1985). The influence of testosterone in the brain of the male rat on levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA). Comparative Biochemistry and Physiology, 80, 411–414Google Scholar

Matsuda, T., Nakano, Y., Kanda, T., & Iwata, H. (1991). Gonadal hormones affect the hypothermia induced by serotonin1A (5HT1A) receptor activation. Life Sciences, 48, 1627–1632CrossRef Google Scholar

Mayberg, H., Brannan, S., Mahurin, R. K., Jerebak, P. A., Brickman, J. S., Tekell, J. L.. (1997). Cingulate function in depression: A potential predictor of treatment response. NeuroReport, 8, 1057–1061CrossRef Google Scholar

Mayberg, H. S. (1994). Frontal lobe dysfunction in secondary depression. Journal of Neuropsychiatry and Clinical Neurosciences, 6, 428–442Google Scholar PubMed

Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S.. (2000). Regional metabolic effects of fluoxetine in major depression: Serial changes and relationship to clinical response. Biological Psychiatry, 48, 830–843CrossRef Google Scholar PubMed

Mayberg, H. S., Lewis, P. J., Regenold, W., & Wagner, H. N. Jr. (1994). Paralimbic Hypoperfusion in Unipolar Depression. Journal of Nuclear Medicine, 35, 929–934Google Scholar PubMed

Mayberg, H. S., Silva, J. A., Brannan, S. K., Tekell, J. L., Mahurin, R. K., McGinnis, S.. (2002). The functional neuroanatomy of the placebo effect. American Journal of Psychiatry, 159, 728–737CrossRef Google Scholar PubMed

McEwen, B. S. (1995). Adrenal steroid action on brain: Dissecting the fine line between protection and damage. In Friedman, M. J., Charney, D. S., & Deutch, A. Y. (Eds.), Neurobiological and clinical consequences of stress: From normal adaptation to PTSD. Philadelphia: Lippincott-RavenGoogle Scholar

McGuffin, P., Katz, R., Watkins, S., & Rutherford, J. (1996). A hospital-based twin register of the heritability of DSM-IV unipolar depression. Archives General Psychiatry, 53, 129–136CrossRef Google Scholar PubMed

McQueen, J. K., Wilson, H., & Fink, G. (1997). Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain. Brain Research. Molecular Brain Research, 45, 13–23CrossRef Google Scholar PubMed

Meijer, O. C., & Kloet, R. (1998). Corticosterone and serotonergic neurotransmission in the hippocampus: Functional implications of central corticosteroid receptor diversity. Critical Reviews in Neurobiology, 12, 1–20CrossRef Google Scholar PubMed

Mendelson, S. D., & McEwen, B. A. (1990). Testosterone increases the concentration of (3H)8-hydroxy-2-(di-n-propylamino)tetralin binding at 5-HT1A receptors in the medial preoptic nucleus of the castrated male rat. European Journal of Pharmacology, 181, 329–331CrossRef Google Scholar PubMed

Mendelson, S. D., & McEwen, B. S. (1991). Autoradiographic analyses of the effects of restraint-induced stress on 5-HT1A, 5-HT1C and 5-HT2 receptors in the dorsal hippocampus of male and female rats. Neuroendocrinology, 54, 454–461CrossRef Google Scholar PubMed

Monteleone, P., Catapano, F., Tortorella, A., & Maj, M. (1997). Cortisol response to d-fenfluramine in patients with obsessive-compulsive disorder and in healthy subjects: evidence for a gender-related effect. Neuropsychobiology, 36, 8–12CrossRef Google Scholar PubMed

Murua, V. S., & Molina, V. A. (1992). Effects of chronic variable stress and antidepressant drugs on behavioral inactivity during an uncontrollable stress: interaction between both treatments. Behavioral Neural Biology, 57, 87–89CrossRef Google Scholar PubMed

Pecins-Thompson, M., Brown, N. A., Kohama, S. G., & Bethea, C. L.. (1996). Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques. Journal of Neuroscience, 16, 7021–7029CrossRef Google Scholar PubMed

Peroutka, S. J., & Snyder, S, H. (1980). Regulation of serotonin2 (5-HT2) receptors labeled with [3H]spiroperidol by chronic treatment with the antidepressant amitriptyline. Journal of Pharmacology and Experimental Therapeutics, 215, 582–587Google Scholar

Pfohl, B., Sherman, B., Schlecte, J., & Stone, R. (1985). Pituitary/adrenal axis rhythm disturbances in psychiatric patients. Archives General Psychiatry, 42, 897–903CrossRef Google Scholar

Raadsheer, F. C., Hoogendijk, W. J., Stam, F. C., Tilders, F. J., & Swaab, D. F. (1994). Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology, 60, 436–444CrossRef Google Scholar PubMed

Reul, J. M., Stec, I., Soder, M., & Holsboer, F. (1993). Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary adrenocortical system. Endocrinology, 133, 312–320CrossRef Google Scholar PubMed

Roca, C. A., Altemus, M., Galliven, E., Schmidt, P. J., Deuster, P., Gold, P.. (1998a). Effect of reproductive hormones on the hypothalamic-pituitary-adrenal axis response to stress. Biological Psychiatry, 43, 46SGoogle Scholar

Roca, C. A., Schmidt, P. J., Altemus, M., Dananceau, M., & Rubinow, D. (1998b, June 21–23). Effects of reproductive steroids on the Hypothalamic-pituitary-adrenal axis response to low dose dexamethasone. Abstract at Neuroendocrine Workshop on Stress, New Orleans

Roca, C. A., Schmidt, P. J., Altemus, M., Deuster, P., Danaceau, M. A., Putnam, K.. (2003). Differential menstrual cycle regulation of hypothalamic-pituitary-adrenal axis in women with premenstrual syndrome and controls. Journal Clinical Endocrinology and Metabolism, 88, 3057–3063CrossRef Google Scholar PubMed

Rousseau, G. G., Baxter, J. D., & Tomkins, G. M. (1972). Glucocorticoid receptors: relations between steroid binding and biological effects. Molecular Biology, 67, 99–115CrossRef Google Scholar PubMed

Rubin, R. T., Poland, R. E., Lesser, I. M., Winston, R. A., & Blodgett, N. (1987). Neuroendocrine aspects of primary endogenous depression I. Cortisol secretory dynamics in patients and matched controls. Archives General Psychiatry, 44, 328–336CrossRef Google Scholar PubMed

Rubinow, D. R., & Roy-Byrne, P. P. (1984). Premenstrual syndromes: overviews from a methodologic perspective. American Journal of Psychiatry, 141, 163–172Google Scholar

Rutter, M. (2002). The interplay of nature, nurture, and developmental influences. Archives General Psychiatry, 59, 996–1000CrossRef Google Scholar PubMed

Ryan, N., Birmaher, B., Perel, J. M., Dahl, R. E., Meyer, V., Al-Shabbout, M.. (1992). Neuroencocrine response to L-5-hydroxytryptophan challenge in prepubertal major depression. Archives of General Psychiatry, 49, 843–851CrossRef Google Scholar PubMed

Sachar, E. J., Hellman, L., Roffwarg, H. P., Halpern, F. S., Fukush, D. K., & Gallagher, T. F. (1973). Disrupted 24 hour patterns of cortisol secretion in psychotic depressives. Archives General Psychiatry, 28, 19–24CrossRef Google Scholar

Schreiber, R., & Vry, J. (1993). Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. European Journal of Pharmacology, 249, 341–351CrossRef Google Scholar PubMed

Seckl, J. R., & Fink, G. (1992). Use of in situ hybridization to investigate the regulation of hippocampal corticosteroid receptors by monoamines. Journal of Steroid Biochemistry and Molecular Biology, 40, 685–688CrossRef Google Scholar

Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003). Untreated depression and hippocampal volume loss. American Journal of Psychiatry, 160, 1516–1518CrossRef Google Scholar PubMed

Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996). Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences, USA, 93, 3908–3913CrossRef Google Scholar PubMed

Southwick, S., Krystal, J., & Morgan, C. (1993). Abnormal noradrenergic function in posttraumatic stress disorder. Archives General Psychiatry, 50, 266–274CrossRef Google Scholar PubMed

Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry, 157, 1552–1562CrossRef Google Scholar PubMed

Svec, F. (1988). Differences in the interaction of RU 486 and ketoconazole with the second binding site of the glucocorticoid receptor. Endocrinology, 123, 1902–1906CrossRef Google Scholar PubMed

Turner, B. B., & Weaver, D. A. (1985). Sexual dimorphism of glucocorticoid binding in rat brain. Brain Research, 343, 16–23CrossRef Google Scholar PubMed

Viau, V., & Meaney, M. J. (1991). Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat. Endocrinology, 129, 2503–2511CrossRef Google Scholar PubMed

Bardeleben, U., Stalla, G. K., Mueller, O. A., & Holsboer, F. (1988). Blunting of ACTH response to CRH in depressed patients is avoided by metyrapone pretreatment. Biological Psychiatry, 24, 782–786CrossRef Google Scholar

Weissman, M. M., & Olfson, M. (1995). Depression in women: implications for health care research. Science, 269, 799–801CrossRef Google Scholar PubMed

Welner, S. A., Montigny, C., Desroches, J., Desjardins, P., & Suranyi-Cadotte, B. E. (1989). Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment. Synapse, 4, 347–352CrossRef Google Scholar PubMed

Yates, M., Leake, A., Candy, J. M., Fairbairn, A. F., McKeith, I. G., & Ferrier, I. N. (1990). 5HT2 receptor changes in major depression. Biological Psychiatry, 27, 489–496CrossRef Google Scholar PubMed

Yoshino, K. (1982). Concentrations of monoamines and monoamine metabolites in cerebrospinal fluid determined by high-performance liquid chromatography with electrochemical detection. Brain & Nerve, 34, 1099–1106Google Scholar PubMed

Young, E. A. (1996). Sex differences in response to exogenous corticosterone. Molecular Psychiatry, 1, 313–319Google Scholar PubMed

Young, E. A., Abelson, J. L., & Cameron, O. G. (2004). Effect of comorbid anxiety disorders on the HPA axis response to a social stressor in major depression. 56:113–120. Biological Psychiatry, in pressCrossRef Google Scholar PubMed

Young, E. A., Aggen, S. H., Prescott, C. A., & Kendler, K. S. (2000). Similarity in saliva cortisol measures in monozygotic twins and the influence of past major depression. Biological Psychiatry, 48, 70–74CrossRef Google Scholar PubMed

Young, E. A., Akil, H., Haskett, R. F., & Watson, S. J.. (1985). Evidence Against Changes In Corticotroph CRF Receptors In Depressed Patients. Biological Psychiatry, 37, 355–363CrossRef Google Scholar

Young, E. A., Altemus, M., Parkison, V, & Shastry, S. (2001). Effects of estrogen antagonists and agonists on the ACTH response to restraint stress. Neuropsychopharmacology, 25, 881–891CrossRef Google Scholar PubMed

Young, E. A., & Breslau, N. (2004). Cortisol and catecholamines in posttraumatic stress disorder: A community study. Archives General Psychiatry, 61, 394–401CrossRef Google Scholar PubMed

Young, E. A., Carlson, N. E., & Brown, M. B. (2001). 24 Hour ACTH and Cortisol Pulsatility in Depressed Women, Neuropsychpoharmacology, 25, 267–276CrossRef Google Scholar PubMed

Young, E. A., Haskett, R. F., Grunhaus, L., Pande, A., Weinberg, V. M., Watson, S. J.. (1994). Increased circadian activation of the hypothalamic pituitary adrenal axis in depressed patients in the evening. Archives General Psychiatry, 51, 701–707CrossRef Google Scholar PubMed

Young, E. A., Haskett, R. F., Watson, S. J. & Akil, H. (1991). Loss of glucocorticoid fast feedback in depression. Archives of General Psychiatry, 48, 693–699CrossRef Google Scholar PubMed

Young, E. A., Kotun, J., Haskett, R. F., Grunhaus, L., Greden, J. F., Watson, S. J.. (1993). Dissociation between pituitary and adrenal suppression to dexamethasone in depression. Archives General Psychiatry, 50, 395–403CrossRef Google Scholar PubMed

Young, E. A., Lopez, J. F., Murphy-Weinberg, V., Watson, S. J., & Akil, H. (1997). Normal pituitary response to metyrapone in the morning in depressed patients: Implications for circadian regulation of CRH secretion, Biological Psychiatry, 41, 1149–1155CrossRef Google Scholar

Young, E. A., & Vazquez, D. (1996). Hypercortisolemia, hippocampal glucocorticoid receptors and fast feedback. Molecular Psychiatry, 1, 149–159Google Scholar PubMed

Young, E. A., Watson, S. J., Kotun, J., Haskett, R. F., Grunhaus, L., Murphy-Weinberg, V.. (1990). Response to low dose oCRH in endogenous depression: role of cortisol feedback. Archives General Psychiatry, 47, 449–457CrossRef Google Scholar

Zweifel, J. E., & O'Brien, W. H. (1997). A meta-analysis of the effect of hormone replacement therapy upon depressed mood. Psychoneuroendocrinology, 22, 189–212CrossRef Google Scholar PubMed